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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:BLi02630, BL01561
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456391 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiQ65HG0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BLi02630

Structurei

3D structure databases

ProteinModelPortaliQ65HG0
SMRiQ65HG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q65HG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHRYLPATD QDKKEMLEAI GVERIDELFS DIPESVRFKG EYQIKKAKSE
60 70 80 90 100
TELTKELTKL AAKNKDTVTY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MICELTGMDI SNSSMYDGGT ALAEAAMLAS
160 170 180 190 200
GHTKKKKIVV SETVHPESRE VLKTYAKGQY IDVVEVPSKN GTADLEALDE
210 220 230 240 250
AVCEDTAAVI VQYPNFFGRI EPLKDIKPIA HKGKSMFIVS ANPLALGLLT
260 270 280 290 300
PPGALGADIV VGDAQPFGIP AAFGGPHCGF FAVTKKLMRK VPGRLVGQTE
310 320 330 340 350
DENGKRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKKG
360 370 380 390 400
VKEIAWQNLQ KAAYAKEAAK RAGLEVAFEG PMFNEFVIRL NEPVEKANER
410 420 430 440
LLEKNIIGGY DLGASYPDLK RHMLIAVTEL RTKEEIDTLM NELGDCHE
Length:448
Mass (Da):49,306
Last modified:October 25, 2004 - v1
Checksum:i12C9EE7B8F423F26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU24145.1
AE017333 Genomic DNA Translation: AAU41504.1
RefSeqiWP_003183435.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU24145; AAU24145; BL01561
AAU41504; AAU41504; BLi02630
GeneIDi3027813
KEGGibld:BLi02630
bli:BL01561

Similar proteinsi

Entry informationi

Entry nameiGCSPA_BACLD
AccessioniPrimary (citable) accession number: Q65HG0
Secondary accession number(s): Q62SW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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