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Q65HG0

- GCSPA_BACLD

UniProt

Q65HG0 - GCSPA_BACLD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2608-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:BLi02630, BL01561
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045639Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL01561.

Structurei

3D structure databases

ProteinModelPortaliQ65HG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65HG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHRYLPATD QDKKEMLEAI GVERIDELFS DIPESVRFKG EYQIKKAKSE
60 70 80 90 100
TELTKELTKL AAKNKDTVTY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MICELTGMDI SNSSMYDGGT ALAEAAMLAS
160 170 180 190 200
GHTKKKKIVV SETVHPESRE VLKTYAKGQY IDVVEVPSKN GTADLEALDE
210 220 230 240 250
AVCEDTAAVI VQYPNFFGRI EPLKDIKPIA HKGKSMFIVS ANPLALGLLT
260 270 280 290 300
PPGALGADIV VGDAQPFGIP AAFGGPHCGF FAVTKKLMRK VPGRLVGQTE
310 320 330 340 350
DENGKRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKKG
360 370 380 390 400
VKEIAWQNLQ KAAYAKEAAK RAGLEVAFEG PMFNEFVIRL NEPVEKANER
410 420 430 440
LLEKNIIGGY DLGASYPDLK RHMLIAVTEL RTKEEIDTLM NELGDCHE
Length:448
Mass (Da):49,306
Last modified:October 25, 2004 - v1
Checksum:i12C9EE7B8F423F26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000002 Genomic DNA. Translation: AAU24145.1.
AE017333 Genomic DNA. Translation: AAU41504.1.
RefSeqiYP_006713980.1. NC_006322.1.
YP_079783.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU24145; AAU24145; BL01561.
AAU41504; AAU41504; BLi02630.
GeneIDi3027813.
3097436.
KEGGibld:BLi02630.
bli:BL01561.
PATRICi18950942. VBIBacLic203714_2673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000002 Genomic DNA. Translation: AAU24145.1 .
AE017333 Genomic DNA. Translation: AAU41504.1 .
RefSeqi YP_006713980.1. NC_006322.1.
YP_079783.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65HG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL01561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU24145 ; AAU24145 ; BL01561 .
AAU41504 ; AAU41504 ; BLi02630 .
GeneIDi 3027813.
3097436.
KEGGi bld:BLi02630.
bli:BL01561.
PATRICi 18950942. VBIBacLic203714_2673.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-2608-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiGCSPA_BACLD
AccessioniPrimary (citable) accession number: Q65HG0
Secondary accession number(s): Q62SW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3