Q65H59 (DEOC1_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 1
Short name=DERA 1
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 1
Phosphodeoxyriboaldolase 1
Short name=Deoxyriboaldolase 1

Gene names

Name:	deoC1
Ordered Locus Names:	BLi02734, BL02102

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
Sequence caution	The sequence AAU41605.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase 1 HAMAP MF_00114		PRO_0000231531
Sites
	Active site	154	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	183	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65H59 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 933EC6967EF3C135	FASTA	223	23,373
	10 20 30 40 50 60 MTKQIARMID HTALKPDTVK SEIEALCKEA RVYGFASVCV NPCWVKLCAE LLKESEVKVC 70 80 90 100 110 120 TVIGFPLGAA SPETKAFETR QAIADGAGEV DMVINIGALK DRDTGTVEHD IRAVTDAADG 130 140 150 160 170 180 KALVKVIIET SLLTDEEKRL ACELAVKAGA DFVKTSTGFS GGGATVRDIK LMREAVGPDI 190 200 210 220 GVKASGGVRD KESALAMIEA GATRIGASAG VSIVKGLTAD EDY

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41605.1. Different initiation. CP000002 Genomic DNA. Translation: AAU24243.1.
RefSeq	YP_079881.1. NC_006270.3. YP_092298.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65H59.
SMR	Q65H59. Positions 3-219.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65H59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000058035; EBBACP00000056566; EBBACG00000058026. EBBACT00000061427; EBBACP00000059860; EBBACG00000061418.
GeneID	3029062. 3097769.
GenomeReviews	Gene locus BLi02734 in contig AE017333_GR. Gene locus BL02102 in contig CP000002_GR.
KEGG	bld:BLi02734. bli:BL02102.
NMPDR	fig|279010.5.peg.3005.
PATRIC	18951156. VBIBacLic203714_2779.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
GeneTree	EBGT00050000000908.
HOGENOM	HBG636421.
OMA	INTQVAV.
PhylomeDB	Q65H59.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02734-MONOMER. BLIC279010:BL02102-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC1_BACLD

Accession

Primary (citable) accession number: Q65H59
Secondary accession number(s): Q62SL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program