Reviewed, UniProtKB/Swiss-Prot Q65GG3 (NTPA_BACLD)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BLi02984, BL00311

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Nucleoside-triphosphatase		PRO_0000178127

Sequences

	Sequence		Length	Mass (Da)
	Q65GG3-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: AAE5372C3082FAD5	FASTA	196	21,512
	10 20 30 40 50 60 MKEVIIATKN EGKVREFKAM LEPRGYDVKS LLDIGYTPEI EETGQTFEEN AVIKAETISK 70 80 90 100 110 120 ETGKIVIADD SGLSVDYLGG SPGVYSARYA GEEKNDLANL KKLLKELEGV EKEDRSARFR 130 140 150 160 170 180 CALAICIPGQ ETKTVEGSVE GYITEEPRGT NGFGYDPVFL VKDKDQTMAE LSSGEKNKIS 190 HRAEALKKLS ALLDQA

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017333 Genomic DNA. Translation: AAU41851.1. CP000002 Genomic DNA. Translation: AAU24490.1.
RefSeq	YP_080128.1. YP_092544.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3028174. 3098491.
GenomeReviews	Gene locus BL00311 in contig CP000002_GR. Gene locus BLi02984 in contig AE017333_GR.
KEGG	bld:BLi02984. bli:BL00311.
NMPDR	fig|279010.5.peg.3333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65GG3.
Enzyme and pathway databases
BioCyc	BLIC279010:BL00311-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BACLD

Accession

Primary (citable) accession number: Q65GG3
Secondary accession number(s): Q62RX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	October 25, 2004
Last modified:	July 22, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)