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Protein

Ribonuclease PH

Gene

rph

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.UniRule annotation

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.UniRule annotation

GO - Molecular functioni

  1. tRNA binding Source: UniProtKB-HAMAP
  2. tRNA nucleotidyltransferase activity Source: UniProtKB-HAMAP
  3. tRNA-specific ribonuclease activity Source: InterPro

GO - Biological processi

  1. tRNA processing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PHUniRule annotation (EC:2.7.7.56UniRule annotation)
Short name:
RNase PHUniRule annotation
Alternative name(s):
tRNA nucleotidyltransferaseUniRule annotation
Gene namesi
Name:rphUniRule annotation
Ordered Locus Names:BLi02985, BL00312
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Ribonuclease PHPRO_1000024777Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL00312.

Structurei

3D structure databases

ProteinModelPortaliQ65GG2.
SMRiQ65GG2. Positions 1-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0689.
HOGENOMiHOG000229516.
KOiK00989.
OMAiGKGQGWV.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65GG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYDGRKNNE LRPVTMDLDF ITHPEGSVLI TVGGTKVICN ASVEDRVPPF
60 70 80 90 100
LRGEGKGWIT AEYSMLPRAT NQRTIRESSK GKISGRTMEI QRLIGRALRA
110 120 130 140 150
VVDLEKLGER TIWIDCDVIQ ADGGTRTASI TGAFTAMALA VGRLVEKGAL
160 170 180 190 200
KEMPITDFLA ATSVGIDKEK GLILDLNYQE DSAAEVDMNV VMTGEGRFVE
210 220 230 240
LQGTGEEATF SRSELDGLLE LAEKGIAELL EKQKEVLGDV ALSIQQ
Length:246
Mass (Da):26,845
Last modified:October 25, 2004 - v1
Checksum:i86BFDAD5A433B890
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU24491.2.
AE017333 Genomic DNA. Translation: AAU41852.1.
RefSeqiYP_006714322.1. NC_006322.1.
YP_080129.2. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU24491; AAU24491; BL00312.
AAU41852; AAU41852; BLi02985.
GeneIDi3028501.
3098495.
KEGGibld:BLi02985.
bli:BL00312.
PATRICi18951694. VBIBacLic203714_3047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU24491.2.
AE017333 Genomic DNA. Translation: AAU41852.1.
RefSeqiYP_006714322.1. NC_006322.1.
YP_080129.2. NC_006270.3.

3D structure databases

ProteinModelPortaliQ65GG2.
SMRiQ65GG2. Positions 1-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BL00312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU24491; AAU24491; BL00312.
AAU41852; AAU41852; BLi02985.
GeneIDi3028501.
3098495.
KEGGibld:BLi02985.
bli:BL00312.
PATRICi18951694. VBIBacLic203714_3047.

Phylogenomic databases

eggNOGiCOG0689.
HOGENOMiHOG000229516.
KOiK00989.
OMAiGKGQGWV.
OrthoDBiEOG6CZQQP.

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2960-MONOMER.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiRNPH_BACLD
AccessioniPrimary (citable) accession number: Q65GG2
Secondary accession number(s): Q62RW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: February 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.