Q65GC0 (ARAA1_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase 1
EC=5.3.1.4

Gene names

Name:	araA1
Ordered Locus Names:	BLi03028, BL00352

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	L-arabinose isomerase 1 HAMAP MF_00519		PRO_0000259335
Sites
	Metal binding	301	1	Manganese By similarity
	Metal binding	326	1	Manganese By similarity
	Metal binding	343	1	Manganese By similarity
	Metal binding	442	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65GC0 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 9AF4964408CF4F55	FASTA	493	55,647
	10 20 30 40 50 60 MIQAKTHVFW FVTGSQHLYG EEAVQEVEEH SKMICNGLND GDLRFQVEYK AVATSLDGVR 70 80 90 100 110 120 KLFEEANRDE ECAGIITWMH TFSPAKMWIP GLSELNKPLL HFHTQFNRDI PWDKIDMDFM 130 140 150 160 170 180 NINQSAHGDR EYGFIGARLG IPRKVIAGYW EDREVKRSID KWMSAAVAYI ESRHIKVARF 190 200 210 220 230 240 GDNMRNVAVT EGDKIEAQIQ LGWSVDGYGI GDLVTEINAV SEQSLSELIS EYEELYEWPE 250 260 270 280 290 300 GEAARESVKE QARIELGLKR FLSSGGYTAF TTTFEDLHGM KQLPGLAVQR LMAEGYGFGG 310 320 330 340 350 360 EGDWKTAALV RMMKMMAGGK ETSFMEDYTY HFEPGNEMIL GSHMLEVCPS IAEHKPRIEV 370 380 390 400 410 420 HPLSMGAKDD PARLVFDGIA GPAVNVSLID LGGRFRLVIN KVEAVKVPHD MPNLPVARVL 430 440 450 460 470 480 WKPQPSLRTS AEAWILAGGA HHTCLSYQLT AEQMLDWAEM SGIEAVLINR DTTILNLRNE 490 LKWSEAAYRL RKF

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41894.1. CP000002 Genomic DNA. Translation: AAU24535.1.
RefSeq	YP_080173.1. NC_006270.3. YP_092587.1. NC_006322.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q65GC0.
SMR	Q65GC0. Positions 1-490.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65GC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000057641; EBBACP00000056172; EBBACG00000057632. EBBACT00000059576; EBBACP00000058009; EBBACG00000059567.
GeneID	3028672. 3098584.
GenomeReviews	Gene locus BLi03028 in contig AE017333_GR. Gene locus BL00352 in contig CP000002_GR.
KEGG	bld:BLi03028. bli:BL00352.
NMPDR	fig|279010.5.peg.3376.
PATRIC	18951784. VBIBacLic203714_3092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
GeneTree	EBGT00050000001793.
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03028-MONOMER. BLIC279010:BL00352-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA1_BACLD

Accession

Primary (citable) accession number: Q65GC0
Secondary accession number(s): Q62RS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program