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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:BLi03060, BL00397
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134321 – 312Malate dehydrogenaseAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi03060

Structurei

3D structure databases

ProteinModelPortaliQ65G89
SMRiQ65G89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q65G89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKRNKVSV IGAGFTGATT AFLTAQKELA DVVLVDIPQL ENPTKGKALD
60 70 80 90 100
MLEASPVQGF DANITGTANY EDTAGSDIVV ITAGIARKPG MSRDDLVATN
110 120 130 140 150
EKIMRSVTKE VVKYSPDCII IVLTNPVDAM TYAVYKESGF PKERVIGQSG
160 170 180 190 200
ILDTARFRTF VAQELNLSVK DITGFVLGGH GDDMVPLVRY SYAGGIPLET
210 220 230 240 250
LLPKDRIDAI VERTRKGGGE IVNLLGNGSA YYAPAASLTE MVEAILKDQR
260 270 280 290 300
RVLPTIAYLE GEYGYEGIYL GVPTIIGGNG LEQIIELELT ETEKSQLDKS
310
VESVKNVMKV LS
Length:312
Mass (Da):33,597
Last modified:October 25, 2004 - v1
Checksum:iED550FFD80503A90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA Translation: AAU41925.1
CP000002 Genomic DNA Translation: AAU24566.1
RefSeqiWP_003184317.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU24566; AAU24566; BL00397
AAU41925; AAU41925; BLi03060
GeneIDi3028960
KEGGibld:BLi03060
bli:BL00397

Similar proteinsi

Entry informationi

Entry nameiMDH_BACLD
AccessioniPrimary (citable) accession number: Q65G89
Secondary accession number(s): Q62RP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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