Q65G68 (ARLY_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BLi03083, BL00416

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Argininosuccinate lyase HAMAP MF_00006		PRO_0000240714

Sequences

	Sequence		Length	Mass (Da)
	Q65G68 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 7EE1D6F5B2682D89	FASTA	459	51,981
	10 20 30 40 50 60 MKKLWGGRFQ KTPEKWVDEF GASIHFDKTL VKEDIAGSLA HASMLEKCGI LTEAEAVKIK 70 80 90 100 110 120 EGLTSLLHKA EKNELDFSVD CEDIHLNLEK MLIDEIGPLG GKLHTARSRN DQVATDMHLY 130 140 150 160 170 180 LKGHTEHIIE LITAFQHVLI EKAEEHVETI LPGYTHLQRA QPISFAHHLL AYFWMLERDK 190 200 210 220 230 240 ERYHDSFKRI NKSPLGCGAL AGTTFPIDRE YSADLLGFDS IYENSLDGVS DRDFILEFLS 250 260 270 280 290 300 ASSILMMHLS RFSEEIILWC SQEFKFIELD DTYATGSSMM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GDLIGLLTIM KGLPLAYNKD LQEDKEGMFD TVKTVEGSLE IFAGMIKTMT VNKNMMKKAT 370 380 390 400 410 420 EQDFSNATEL ADYLAKKGMP FREAHEVVGR LVFTCIEKGI YLSGLPFEEF KKASGLFEED 430 440 450 VYIVLDPHHA VEKRMSEGGT GFKKVTEAIQ KAKQCLNNF

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41946.1. CP000002 Genomic DNA. Translation: AAU24588.1.
RefSeq	YP_080226.1. NC_006270.3. YP_092639.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65G68.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65G68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000054359; EBBACP00000052890; EBBACG00000054350. EBBACT00000058854; EBBACP00000057287; EBBACG00000058845.
GeneID	3028973. 3098707.
GenomeReviews	Gene locus BLi03083 in contig AE017333_GR. Gene locus BL00416 in contig CP000002_GR.
KEGG	bld:BLi03083. bli:BL00416.
NMPDR	fig|279010.5.peg.3444.
PATRIC	18951902. VBIBacLic203714_3151.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
GeneTree	EBGT00070000031828.
HOGENOM	HBG539632.
OMA	MAEDLIF.
PhylomeDB	Q65G68.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03083-MONOMER. BLIC279010:BL00416-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BACLD

Accession

Primary (citable) accession number: Q65G68
Secondary accession number(s): Q62RM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program