Q65G65 (ACKA_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	BLi03086, BL00419

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Acetate kinase HAMAP MF_00020		PRO_0000107532

Sequences

	Sequence		Length	Mass (Da)
	Q65G65 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 1693BB377CFA01B9	FASTA	395	43,290
	10 20 30 40 50 60 MSKIIAINAG SSSLKFQLFE MPSEKVLTKG LVERIGLDNG IFTISVNDEK KTETTDIPDH 70 80 90 100 110 120 SVAVKMLLDK LTKFGIIKDL NEIDGIGHRV VHGGEKFSDS VLLTDEMIHE IEEISELAPL 130 140 150 160 170 180 HNPANIVGIK AFKEVLPNVP AVAVFDTAFH QTMPEQSYLY SLPYEYYEKF GIRKYGFHGT 190 200 210 220 230 240 SHKYVTERAA ELLGRPIEEL RLISCHLGNG ASIAAVEGGK SIDTSMGFTP LAGVAMGTRS 250 260 270 280 290 300 GNIDPALIPF IMEKTGQTAD EVLNTLNKKS GLLGISGFSS DLRDIVEATK EGNERAETAL 310 320 330 340 350 360 EVFASRIHKY IGSYAARMSG VDAIIFTAGI GENSVEVRER VLHGLEFMGV YWDPALNNVR 370 380 390 GKEAFISYPH SPVKVIVIPT NEEVMIARDV VRLAH

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41949.1. CP000002 Genomic DNA. Translation: AAU24591.2.
RefSeq	YP_080229.2. NC_006270.3. YP_092642.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65G65.
SMR	Q65G65. Positions 3-394.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65G65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000054344; EBBACP00000052875; EBBACG00000054335. EBBACT00000060910; EBBACP00000059343; EBBACG00000060901.
GeneID	3028976. 3098721.
GenomeReviews	Gene locus BLi03086 in contig AE017333_GR. Gene locus BL00419 in contig CP000002_GR.
KEGG	bld:BLi03086. bli:BL00419.
NMPDR	fig|279010.5.peg.3447.
PATRIC	18951908. VBIBacLic203714_3154.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
GeneTree	EBGT00050000000769.
HOGENOM	HBG285863.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03086-MONOMER. BLIC279010:BL00419-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_BACLD

Accession

Primary (citable) accession number: Q65G65
Secondary accession number(s): Q62RL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program