Q65G58 (PPNK2_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 2
Short name=Poly(P)/ATP NAD kinase 2
EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	BLi03093, BL00367

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229605

Sequences

	Sequence		Length	Mass (Da)
	Q65G58 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 664FE2095DC6A18F	FASTA	265	30,063
	10 20 30 40 50 60 MTDRRNIYFF YKKSEETDEQ CKKLKQLAEE HGFRVVHHHN EANIIASIGG DGTFLQAVRK 70 80 90 100 110 120 TNFRDDCLYV GVAKKGKAHL YADFNIYDTD KMIEATNSEQ IEVRKYPLID VTVDGTSFQC 130 140 150 160 170 180 LNEVSIRSSI IKTFVMDVYI DDLHFETFRG DGMIVSTPTG STAYNKSVDG AIVDPLIPCI 190 200 210 220 230 240 QVTELASLNN NTYRTLGSPF ILSADRKLTL KIVQDGNDYP IIGLDNEAFS TMNVKEVEVS 250 260 LSGKMIKTIK LKDNSFWEKV RRTFL

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41956.1. CP000002 Genomic DNA. Translation: AAU24598.1.
RefSeq	YP_080236.1. NC_006270.3. YP_092649.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65G58.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65G58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000057451; EBBACP00000055982; EBBACG00000057442. EBBACT00000061097; EBBACP00000059530; EBBACG00000061088.
GeneID	3028995. 3098741.
GenomeReviews	Gene locus BLi03093 in contig AE017333_GR. Gene locus BL00367 in contig CP000002_GR.
KEGG	bld:BLi03093. bli:BL00367.
NMPDR	fig|279010.5.peg.3454.
PATRIC	18951924. VBIBacLic203714_3162.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000002705.
HOGENOM	HBG314020.
OMA	DDLHFET.
PhylomeDB	Q65G58.
ProtClustDB	PRK03501.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03093-MONOMER. BLIC279010:BL00367-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK2_BACLD

Accession

Primary (citable) accession number: Q65G58
Secondary accession number(s): Q62RL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program