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Protein

NAD kinase 2

Gene

nadK2

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton acceptorUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei186NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 52NADUniRule annotation2
Nucleotide bindingi122 – 123NADUniRule annotation2
Nucleotide bindingi162 – 167NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:G1G12-3128-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:BLi03093, BL00367
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296051 – 265NAD kinase 2Add BLAST265

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi03093

Structurei

3D structure databases

ProteinModelPortaliQ65G58
SMRiQ65G58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiEVRKYPL

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q65G58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRRNIYFF YKKSEETDEQ CKKLKQLAEE HGFRVVHHHN EANIIASIGG
60 70 80 90 100
DGTFLQAVRK TNFRDDCLYV GVAKKGKAHL YADFNIYDTD KMIEATNSEQ
110 120 130 140 150
IEVRKYPLID VTVDGTSFQC LNEVSIRSSI IKTFVMDVYI DDLHFETFRG
160 170 180 190 200
DGMIVSTPTG STAYNKSVDG AIVDPLIPCI QVTELASLNN NTYRTLGSPF
210 220 230 240 250
ILSADRKLTL KIVQDGNDYP IIGLDNEAFS TMNVKEVEVS LSGKMIKTIK
260
LKDNSFWEKV RRTFL
Length:265
Mass (Da):30,063
Last modified:October 25, 2004 - v1
Checksum:i664FE2095DC6A18F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA Translation: AAU41956.1
CP000002 Genomic DNA Translation: AAU24598.1
RefSeqiWP_009329373.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU24598; AAU24598; BL00367
AAU41956; AAU41956; BLi03093
GeneIDi3028995
KEGGibld:BLi03093
bli:BL00367
PATRICifig|279010.13.peg.3159

Similar proteinsi

Entry informationi

Entry nameiNADK2_BACLD
AccessioniPrimary (citable) accession number: Q65G58
Secondary accession number(s): Q62RL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome