UDP-N-acetylmuramate--L-alanine ligase - Bacillus licheniformis (strain DSM 13 / ATCC 14580)

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Q65G22 (MURC_BACLD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BLi03131, BL00050

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm By similarity HAMAP MF_00046.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 432

432

UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046

PRO_0000182053

Regions

Nucleotide binding

108 – 114

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q65G22 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 2046A32014ADDA22
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FASTA

432

48,649

        10         20         30         40         50         60 
MTVYHFVGIK GTGMSPLAQI LHDNGYNVQG SDIEKYIFTQ TALEERNIPI YPFDPENIKP 

        70         80         90        100        110        120 
GMTVIAGNAF PDTHPEIEKA QAEGLPVVRY HKFLGDYLKK FTSIAVTGAH GKTSTTGLLS 

       130        140        150        160        170        180 
HVIKKAKPTS YLIGDGTGKG CENSEYFVLE ACEYRRHFLS YQPDYAIMTN IDFDHPDYFA 

       190        200        210        220        230        240 
NIDDVFDAFQ TMALQVNKGI IACGDDEYLM KIHANVPVVY YGFAEENDFQ ARNVIKNTEG 

       250        260        270        280        290        300 
TTFDVFVRNT FYDTFYIPAY GSHNVLNALA VIALCHYEQV DVDIIKEGLQ TFGGVKRRFN 

       310        320        330        340        350        360 
EKHAGSQVLI DDYAHHPTEI TVTIEAARQK YPERDIVAVF QPHTFTRTQS FLNEFAESLK 

       370        380        390        400        410        420 
KADYVYLCDI FGSARENAGK LTIGDLQEKI PQAKLIDEND TSILKEHENA VLIFMGAGDI 

       430 
QKYLRAYENV LA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
[2]	"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
[3]	Berka R.M., Rey M.W., Ramaiya P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 226.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41992.1. CP000002 Genomic DNA. Translation: AAU24633.2.
RefSeq	YP_080271.2. NC_006270.3. YP_092685.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65G22.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65G22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000055808; EBBACP00000054339; EBBACG00000055799. EBBACT00000062148; EBBACP00000060581; EBBACG00000062139.
GeneID	3028444. 3098842.
GenomeReviews	Gene locus BLi03131 in contig AE017333_GR. Gene locus BL00050 in contig CP000002_GR.
KEGG	bld:BLi03131. bli:BL00050.
NMPDR	fig\|279010.5.peg.103.
PATRIC	18952000. VBIBacLic203714_3200.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0773.
GeneTree	EBGT00050000000630.
HOGENOM	HBG476594.
PhylomeDB	Q65G22.
ProtClustDB	PRK00421.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03131-MONOMER. BLIC279010:BL00050-MONOMER.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01924.
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. MurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BACLD

Accession

Primary (citable) accession number: Q65G22
Secondary accession number(s): Q62RH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents