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Q65FX8

- SYL_BACLD

UniProt

Q65FX8 - SYL_BACLD

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BLi03175, BL00016
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligasePRO_0000151971Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL00016.

Structurei

3D structure databases

ProteinModelPortaliQ65FX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65FX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFDHQTIEK KWQDYWLKNK TFATREDKSK PKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAVFT
110 120 130 140 150
EQNIDNFRRQ IRALGFSYDW DREVNTTDPD YYKWTQWIFL KLYEKGLAYV
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW MLKITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGAHV HFAVDGTNET FTVFTTRPDT
260 270 280 290 300
LFGATYAVLA PEHDLVQKIT TPEQKDAVNA YIEEVQSKSD LERTDLAKTK
310 320 330 340 350
TGVFTGAYAV NPANGEKIPV WIADYVLATY GTGAVMAVPA HDERDHEFAS
360 370 380 390 400
AFGLPIKEVV KGGDVEKEAY TGDGEHIHSD FLNGLDKAAA IEKMIQWLEE
410 420 430 440 450
NGKGEKKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTSTPV PEEELPLILP
460 470 480 490 500
KTSEIKPSGT GESPLANIKE WVEVTDPETG KKGRRETNTM PQWAGSCWYF
510 520 530 540 550
LRYIDPKNPN ELASPEKLKE WLPVDMYIGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
IGVVPTKEPF KQLYNQGMIL GENNEKMSKS KGNVVNPDEI VETHGADTLR
610 620 630 640 650
LYEMFMGPLD ASIAWSTTGL DGARRFLDRV WRLFIDDNGG LNEKIVEGAG
660 670 680 690 700
ETLERVYHET VMKVTDHFEG LRFNTGISQL MVFINEAYKA DQLPKEYMEG
710 720 730 740 750
FVKLLSPVAP HLAEELWNRL GHEETIAYEA WPVYDEAKLV DDEIEIVVQL
760 770 780 790 800
NGKVKAKLNV PADADKEQLE ELAKNNEKVK EQLEGKTIRK VIAVPGKLVN

IVAN
Length:804
Mass (Da):91,635
Last modified:October 25, 2004 - v1
Checksum:i8771DEBA2523A0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU42036.1.
CP000002 Genomic DNA. Translation: AAU24674.1.
RefSeqiYP_006714507.1. NC_006322.1.
YP_080312.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU24674; AAU24674; BL00016.
AAU42036; AAU42036; BLi03175.
GeneIDi3028705.
3098985.
KEGGibld:BLi03175.
bli:BL00016.
PATRICi18952092. VBIBacLic203714_3246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU42036.1 .
CP000002 Genomic DNA. Translation: AAU24674.1 .
RefSeqi YP_006714507.1. NC_006322.1.
YP_080312.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65FX8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL00016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU24674 ; AAU24674 ; BL00016 .
AAU42036 ; AAU42036 ; BLi03175 .
GeneIDi 3028705.
3098985.
KEGGi bld:BLi03175.
bli:BL00016.
PATRICi 18952092. VBIBacLic203714_3246.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-3147-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiSYL_BACLD
AccessioniPrimary (citable) accession number: Q65FX8
Secondary accession number(s): Q62RD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3