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Q65FX8

- SYL_BACLD

UniProt

Q65FX8 - SYL_BACLD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-3147-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BLi03175, BL00016
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_0000151971Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL00016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65FX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65FX8-1 [UniParc]FASTAAdd to Basket

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    MSFDHQTIEK KWQDYWLKNK TFATREDKSK PKFYALDMFP YPSGAGLHVG    50
    HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAVFT 100
    EQNIDNFRRQ IRALGFSYDW DREVNTTDPD YYKWTQWIFL KLYEKGLAYV 150
    DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW MLKITAYADR 200
    LLEDLEELDW PESIKEMQRN WIGRSEGAHV HFAVDGTNET FTVFTTRPDT 250
    LFGATYAVLA PEHDLVQKIT TPEQKDAVNA YIEEVQSKSD LERTDLAKTK 300
    TGVFTGAYAV NPANGEKIPV WIADYVLATY GTGAVMAVPA HDERDHEFAS 350
    AFGLPIKEVV KGGDVEKEAY TGDGEHIHSD FLNGLDKAAA IEKMIQWLEE 400
    NGKGEKKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTSTPV PEEELPLILP 450
    KTSEIKPSGT GESPLANIKE WVEVTDPETG KKGRRETNTM PQWAGSCWYF 500
    LRYIDPKNPN ELASPEKLKE WLPVDMYIGG AEHAVLHLLY ARFWHKFLYD 550
    IGVVPTKEPF KQLYNQGMIL GENNEKMSKS KGNVVNPDEI VETHGADTLR 600
    LYEMFMGPLD ASIAWSTTGL DGARRFLDRV WRLFIDDNGG LNEKIVEGAG 650
    ETLERVYHET VMKVTDHFEG LRFNTGISQL MVFINEAYKA DQLPKEYMEG 700
    FVKLLSPVAP HLAEELWNRL GHEETIAYEA WPVYDEAKLV DDEIEIVVQL 750
    NGKVKAKLNV PADADKEQLE ELAKNNEKVK EQLEGKTIRK VIAVPGKLVN 800
    IVAN 804
    Length:804
    Mass (Da):91,635
    Last modified:October 25, 2004 - v1
    Checksum:i8771DEBA2523A0EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU42036.1.
    CP000002 Genomic DNA. Translation: AAU24674.1.
    RefSeqiYP_006714507.1. NC_006322.1.
    YP_080312.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU24674; AAU24674; BL00016.
    AAU42036; AAU42036; BLi03175.
    GeneIDi3028705.
    3098985.
    KEGGibld:BLi03175.
    bli:BL00016.
    PATRICi18952092. VBIBacLic203714_3246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU42036.1 .
    CP000002 Genomic DNA. Translation: AAU24674.1 .
    RefSeqi YP_006714507.1. NC_006322.1.
    YP_080312.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65FX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL00016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU24674 ; AAU24674 ; BL00016 .
    AAU42036 ; AAU42036 ; BLi03175 .
    GeneIDi 3028705.
    3098985.
    KEGGi bld:BLi03175.
    bli:BL00016.
    PATRICi 18952092. VBIBacLic203714_3246.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BLIC279010:GJ2P-3147-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiSYL_BACLD
    AccessioniPrimary (citable) accession number: Q65FX8
    Secondary accession number(s): Q62RD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3