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Q65FV7

- PCKA_BACLD

UniProt

Q65FV7 - PCKA_BACLD

Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

    Catalytic activityi

    ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Metal bindingi198 – 1981ManganeseUniRule annotation
    Binding sitei198 – 1981ATPUniRule annotation
    Binding sitei198 – 1981SubstrateUniRule annotation
    Metal bindingi217 – 2171Manganese; via tele nitrogenUniRule annotation
    Binding sitei217 – 2171ATPUniRule annotation
    Metal bindingi254 – 2541ManganeseUniRule annotation
    Binding sitei282 – 2821ATPUniRule annotation
    Binding sitei319 – 3191ATPUniRule annotation
    Binding sitei319 – 3191SubstrateUniRule annotation
    Binding sitei444 – 4441ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi233 – 2419ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-3168-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
    Short name:
    PCKUniRule annotation
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckAUniRule annotation
    Ordered Locus Names:BLi03197, BL00839
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Phosphoenolpyruvate carboxykinase [ATP]PRO_0000236919Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL00839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65FV7.
    SMRiQ65FV7. Positions 16-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1866.
    HOGENOMiHOG000271471.
    KOiK01610.
    OMAiGADPEHY.
    OrthoDBiEOG6DG2RK.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00453. PEPCK_ATP.
    InterProiIPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PfamiPF01293. PEPCK_ATP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    TIGRFAMsiTIGR00224. pckA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65FV7-1 [UniParc]FASTAAdd to Basket

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    MNSVDLTTDL QTLLTGENVQ MNLSVPHLVE KILERKEGVL TSSGAVRATT    50
    GTYTGRSPKD KFIVEEASTK DKIDWGAVNQ PISEAAFDRL YAKVLGYLKE 100
    RDELYVFEGF AGADEKYRLP ITVVNEFAWH NLFARQLFIR PEEHDKKPEE 150
    QPFTILSAPH FKADPLVDGT RSETFIIVSF EKRTILIGGT EYAGEMKKSI 200
    FSIMNFLLPE QNILPMHCSA NIGEEGGTAL FFGLSGTGKT TLSADPKRKL 250
    IGDDEHGWSS TGVFNIEGGC YAKCINLSEE KEPQIYNAIR FGSVLENVVV 300
    DSKTGEPDYS DSFYTENTRA AYPIDAIDNI VKPSIAAHPQ TIVFLTADAF 350
    GVLPPISKLT KEQAMYHFLS GYTSKLAGTE RGITTPEATF STCFGSPFLP 400
    LPAHVYAEML GRKIDEHGVG VFLVNTGWTG GGYGTGERMS LAYTRAMVQA 450
    AIEGELDKAE MRTDRIFGLH SPVHVPGVPD QVLDPAKTWT DENEYEEKAI 500
    HLAKAFKQNF KKFSNTENIE KAGGPLV 527
    Length:527
    Mass (Da):58,167
    Last modified:October 25, 2004 - v1
    Checksum:iBE2002BCB9FF58C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU42057.1.
    CP000002 Genomic DNA. Translation: AAU24695.1.
    RefSeqiYP_006714528.1. NC_006322.1.
    YP_080333.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU24695; AAU24695; BL00839.
    AAU42057; AAU42057; BLi03197.
    GeneIDi3027890.
    3099051.
    KEGGibld:BLi03197.
    bli:BL00839.
    PATRICi18952140. VBIBacLic203714_3270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU42057.1 .
    CP000002 Genomic DNA. Translation: AAU24695.1 .
    RefSeqi YP_006714528.1. NC_006322.1.
    YP_080333.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65FV7.
    SMRi Q65FV7. Positions 16-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL00839.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU24695 ; AAU24695 ; BL00839 .
    AAU42057 ; AAU42057 ; BLi03197 .
    GeneIDi 3027890.
    3099051.
    KEGGi bld:BLi03197.
    bli:BL00839.
    PATRICi 18952140. VBIBacLic203714_3270.

    Phylogenomic databases

    eggNOGi COG1866.
    HOGENOMi HOG000271471.
    KOi K01610.
    OMAi GADPEHY.
    OrthoDBi EOG6DG2RK.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci BLIC279010:GJ2P-3168-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00453. PEPCK_ATP.
    InterProi IPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    Pfami PF01293. PEPCK_ATP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    TIGRFAMsi TIGR00224. pckA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiPCKA_BACLD
    AccessioniPrimary (citable) accession number: Q65FV7
    Secondary accession number(s): Q62RB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3