Reviewed, UniProtKB/Swiss-Prot Q65FP0 (UPPP2_BACLD)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	BLi03290, BL02576

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151106
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	48 – 68	21	Potential
	Transmembrane	92 – 112	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	196 – 216	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	255 – 275	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q65FP0-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 2EAD027BDD8435C6	FASTA	276	30,370
	10 20 30 40 50 60 MNIWDIIVAI ILGIVEGLTE YAPVSSTGHM IIVDDVWLKS KELLTPEAAN TFKVVIQLGS 70 80 90 100 110 120 ILAVAFVFKD RILNLLGMKK NITEEQKSGN RLSIAQIAVG LVPAAVLGFL FEDYIDQYLF 130 140 150 160 170 180 SVRTVAVGLI AGAVLMLAAD WINRRKDTTD SVDRMTYKQA LGMGLFQCLA LWPGFSRSGS 190 200 210 220 230 240 TISGGVILGL SHRAAADFTF IMAIPIMMGA SLLSLIKNWA YLSADLLPFF IAGFISAFIV 250 260 270 ALFVVRFFLR LINKIKLVPF AIYRIVLGLL LFILFL

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017333 Genomic DNA. Translation: AAU42124.1. CP000002 Genomic DNA. Translation: AAU24761.1.
RefSeq	YP_080399.1. YP_092817.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65FP0.
Genome annotation databases
GeneID	3027920. 3099356.
GenomeReviews	Gene locus BLi03290 in contig AE017333_GR. Gene locus BL02576 in contig CP000002_GR.
KEGG	bld:BLi03290. bli:BL02576.
NMPDR	fig|279010.5.peg.2854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65FP0.
OMA	FEIAIQL.
Enzyme and pathway databases
BioCyc	BLIC279010:BL02576-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BACLD

Accession

Primary (citable) accession number: Q65FP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)