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Q65FP0

- UPPP2_BACLD

UniProt

Q65FP0 - UPPP2_BACLD

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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Ordered Locus Names:BLi03290, BL02576
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatase 2PRO_0000151106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL02576.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Transmembranei48 – 6821HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei119 – 13921HelicalUniRule annotationAdd
BLAST
Transmembranei196 – 21621HelicalUniRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27521HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFMNMFEY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65FP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIWDIIVAI ILGIVEGLTE YAPVSSTGHM IIVDDVWLKS KELLTPEAAN
60 70 80 90 100
TFKVVIQLGS ILAVAFVFKD RILNLLGMKK NITEEQKSGN RLSIAQIAVG
110 120 130 140 150
LVPAAVLGFL FEDYIDQYLF SVRTVAVGLI AGAVLMLAAD WINRRKDTTD
160 170 180 190 200
SVDRMTYKQA LGMGLFQCLA LWPGFSRSGS TISGGVILGL SHRAAADFTF
210 220 230 240 250
IMAIPIMMGA SLLSLIKNWA YLSADLLPFF IAGFISAFIV ALFVVRFFLR
260 270
LINKIKLVPF AIYRIVLGLL LFILFL
Length:276
Mass (Da):30,370
Last modified:October 25, 2004 - v1
Checksum:i2EAD027BDD8435C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU42124.1.
CP000002 Genomic DNA. Translation: AAU24761.1.
RefSeqiWP_011198234.1. NC_006322.1.
YP_006714594.1. NC_006322.1.
YP_080399.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU24761; AAU24761; BL02576.
AAU42124; AAU42124; BLi03290.
GeneIDi3027920.
3099356.
KEGGibld:BLi03290.
bli:BL02576.
PATRICi18952332. VBIBacLic203714_3342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU42124.1 .
CP000002 Genomic DNA. Translation: AAU24761.1 .
RefSeqi WP_011198234.1. NC_006322.1.
YP_006714594.1. NC_006322.1.
YP_080399.1. NC_006270.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL02576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU24761 ; AAU24761 ; BL02576 .
AAU42124 ; AAU42124 ; BLi03290 .
GeneIDi 3027920.
3099356.
KEGGi bld:BLi03290.
bli:BL02576.
PATRICi 18952332. VBIBacLic203714_3342.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FMNMFEY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-3259-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiUPPP2_BACLD
AccessioniPrimary (citable) accession number: Q65FP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3