Q65FL6 (G6PI_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BLi03314, BL02591

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180590
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity
Amino acid modifications
	Modified residue	38	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65FL6 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 0BDC70F796E549CB	FASTA	450	50,844
	10 20 30 40 50 60 MTHVRFDYSR ALPFFKEQEL TYLRDFVKVA HHTIHEKTGA GSDFLGWVDL PTDYDKEEFA 70 80 90 100 110 120 RIKKCAEKIQ NDSDVLLVVG IGGSYLGARA AIEMLNHSFY NVLPKEKRKT PQVIFIGNNI 130 140 150 160 170 180 SSSYMRDVMD LLEDADFSIN VISKSGTTTE PAIAFRIFRK LLEEKYGKEE AKRRIYATTD 190 200 210 220 230 240 KERGALKTLA NEEGFESFII PDDVGGRFSV LTAVGLLPIA VSGADIDEMM KGARDASKDF 250 260 270 280 290 300 STSELEDNPA YQYAVVRNVL YNKGKTIEML INYEPGLQYF AEWWKQLFGE SEGKDEKGIY 310 320 330 340 350 360 PSSANFSTDL HSLGQYVQEG RRDMFETVLN VEKPRHELTI EEADNDLDGL NYLAGKTVDF 370 380 390 400 410 420 VNKKAFQGTM LAHTDGNVPN LIVNVPEMNA YTFGYLVYFF EKACAMSGYL LGVNPFDQPG 430 440 450 VEAYKVNMFA LLGKPGFEEK KAELEKRLNQ

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU42148.1. CP000002 Genomic DNA. Translation: AAU24783.1.
RefSeq	YP_080421.1. NC_006270.3. YP_092841.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65FL6.
SMR	Q65FL6. Positions 4-448.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65FL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000056682; EBBACP00000055213; EBBACG00000056673. EBBACT00000058538; EBBACP00000056971; EBBACG00000058529.
GeneID	3028647. 3099433.
GenomeReviews	Gene locus BLi03314 in contig AE017333_GR. Gene locus BL02591 in contig CP000002_GR.
KEGG	bld:BLi03314. bli:BL02591.
NMPDR	fig|279010.5.peg.3540.
PATRIC	18952380. VBIBacLic203714_3366.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
GeneTree	EBGT00050000001561.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03314-MONOMER. BLIC279010:BL02591-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACLD

Accession

Primary (citable) accession number: Q65FL6
Secondary accession number(s): Q62R27

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program