Reviewed, UniProtKB/Swiss-Prot Q65FE0 (FENR2_BACLD)

Names and origin

Protein names

Recommended name:
    Ferredoxin--NADP reductase 2
      Short name=Fd-NADP+ reductase 2
      Short name=FNR 2
    EC=1.18.1.2

Gene names

Ordered Locus Names:

BLi03393, BL03143

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: HAMAP NADP or NADPH binding Inferred from electronic annotation. Source: HAMAP ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ferredoxin--NADP reductase 2 HAMAP MF_01685		PRO_0000364798
Sites
	Binding site	37	1	FAD By similarity
	Binding site	45	1	FAD By similarity
	Binding site	50	1	FAD By similarity
	Binding site	90	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	124	1	FAD; via amide nitrogen By similarity
	Binding site	285	1	FAD By similarity
	Binding site	326	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65FE0-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 27FA2F1F0D583B36	FASTA	332	36,806
	10 20 30 40 50 60 MREDTKVYDI TIIGGGPVGL FTAFYGGMRQ ASVKIIESLP QLGGQLSALY PEKYIYDVAG 70 80 90 100 110 120 FPKIRAQELV DNLKEQMAKF DQTVCLEQAV ESVEKQADGI FKLVTNKEIH YSKTVIITAG 130 140 150 160 170 180 NGAFQPRKLE LESAAQFENA NLHYFIDDLN QFAGKRVAVL GGGDSAVDWA LMLEPIAKEV 190 200 210 220 230 240 SIIHRRDKFR AHEHSVENLR NSKVNVLTPF VPTELIGSER IEQIVIEEVK GERKEIIDVD 250 260 270 280 290 300 DVIVNFGFVS SLGPIKNWGL EIEKNSIVVK STMETNIEGF YAAGDICTYE GKVKLIASGF 310 320 330 GEAPTAVNNA KAYMDPKARV QPLHSTSMFE NK

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000002 Genomic DNA. Translation: AAU24855.1. AE017333 Genomic DNA. Translation: AAU42224.1.
RefSeq	YP_080493.1. YP_092917.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65FE0.
Genome annotation databases
GeneID	3027567. 3099711.
GenomeReviews	Gene locus BLi03393 in contig AE017333_GR. Gene locus BL03143 in contig CP000002_GR.
KEGG	bld:BLi03393. bli:BL03143.
NMPDR	fig|279010.5.peg.3642.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65FE0.
OMA	DWALMLE.
Enzyme and pathway databases
BioCyc	BLIC279010:BL03143-MON.
Family and domain databases
HAMAP	MF_01685. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

FENR2_BACLD

Accession

Primary (citable) accession number: Q65FE0
Secondary accession number(s): Q62QV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)