Q65E26 (FABZ_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl ACP dehydrase
EC=4.2.1.-

Gene names

Name:	fabZ
Ordered Locus Names:	BLi03873, BL02496

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in saturated fatty acids biosynthesis. HAMAP MF_00406
Subcellular location	Cytoplasm By similarity HAMAP MF_00406.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydro-lyase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase HAMAP MF_00406		PRO_0000091640
Sites
	Active site	48	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65E26 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 3BEB992883496439	FASTA	144	16,092
	10 20 30 40 50 60 MLDAQQIKEI IPHRYPFLLV DRVTEVEEGK RAAGYKNVTV NEEFFNGHFP DYPVMPGVLI 70 80 90 100 110 120 VEALAQVGAV ALLMKEENRG RLAFFAGIDS CRFKKQVKPG DQLHLELEVL RFRGSIGKGK 130 140 GVAKVDGEVV CEAELMFSLG EKQE

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU42688.1. CP000002 Genomic DNA. Translation: AAU25313.1.
RefSeq	YP_080951.1. NC_006270.3. YP_093381.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65E26.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65E26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000055037; EBBACP00000053568; EBBACG00000055028. EBBACT00000060908; EBBACP00000059341; EBBACG00000060899.
GeneID	3028437. 3101084.
GenomeReviews	Gene locus BLi03873 in contig AE017333_GR. Gene locus BL02496 in contig CP000002_GR.
KEGG	bld:BLi03873. bli:BL02496.
NMPDR	fig|279010.5.peg.4065.
PATRIC	18953540. VBIBacLic203714_3945.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0764.
GeneTree	EBGT00050000002061.
HOGENOM	HBG433282.
OMA	KKQVTPG.
ProtClustDB	PRK00006.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI03873-MONOMER. BLIC279010:BL02496-MONOMER.
Family and domain databases
HAMAP	MF_00406. FabZ. [Tree]
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
KO	K02372.
Pfam	PF07977. FabA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01750. FabZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABZ_BACLD

Accession

Primary (citable) accession number: Q65E26
Secondary accession number(s): Q62PJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program