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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi75 – 751Manganese 1UniRule annotation
Metal bindingi75 – 751Manganese 2UniRule annotation
Metal bindingi97 – 971Manganese 2UniRule annotation
Metal bindingi149 – 1491Manganese 2UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3835-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:BLi03882, BL02502
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable manganese-dependent inorganic pyrophosphatasePRO_1000012310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi03882.

Structurei

3D structure databases

ProteinModelPortaliQ65E18.
SMRiQ65E18. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65E18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVLIFGHK NPDTDTICSA IAYAELKKEL GMDAEPVRLG EINGETEYAL
60 70 80 90 100
KKFNAEVPRL VNTVANETDS VILVDHNERQ QSVDDLDQVR VLEVIDHHRI
110 120 130 140 150
ANFETSDPLY YRAEPVGCTA TILNKLYKEN GVEIKKDIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE EDVKAAKELA AIAGVDADSY GLDMLKAGAD LSAKTIPQLL
210 220 230 240 250
SLDAKEFTMG SHKVEIAQVN TVDTNDVLSR KEEVDAELAK AVSEKGLDLF
260 270 280 290 300
VFVVTDILTN DSVVVASGQA AQAVEKAFNV TLADNTATLK GVVSRKKQIV

PPLTEALKG
Length:309
Mass (Da):33,460
Last modified:October 25, 2004 - v1
Checksum:i6FF52F4F16F88853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25322.1.
AE017333 Genomic DNA. Translation: AAU42696.1.
RefSeqiWP_003185920.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU25322; AAU25322; BL02502.
AAU42696; AAU42696; BLi03882.
GeneIDi3027962.
KEGGibld:BLi03882.
bli:BL02502.
PATRICi18953558. VBIBacLic203714_3954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25322.1.
AE017333 Genomic DNA. Translation: AAU42696.1.
RefSeqiWP_003185920.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65E18.
SMRiQ65E18. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi03882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25322; AAU25322; BL02502.
AAU42696; AAU42696; BLi03882.
GeneIDi3027962.
KEGGibld:BLi03882.
bli:BL02502.
PATRICi18953558. VBIBacLic203714_3954.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3835-MONOMER.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_BACLD
AccessioniPrimary (citable) accession number: Q65E18
Secondary accession number(s): Q62PI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.