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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciBLIC279010:G1G12-3900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:BLi03882, BL02502
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000123101 – 309Probable manganese-dependent inorganic pyrophosphataseAdd BLAST309

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi03882

Structurei

3D structure databases

ProteinModelPortaliQ65E18
SMRiQ65E18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M Bacteria
COG1227 LUCA
HOGENOMiHOG000223999
KOiK15986
OMAiSTPLECW

Family and domain databases

Gene3Di3.10.310.20, 1 hit
HAMAPiMF_00207 PPase_C, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
IPR022934 Mn-dep_inorganic_PyrPase
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit

Sequencei

Sequence statusi: Complete.

Q65E18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVLIFGHK NPDTDTICSA IAYAELKKEL GMDAEPVRLG EINGETEYAL
60 70 80 90 100
KKFNAEVPRL VNTVANETDS VILVDHNERQ QSVDDLDQVR VLEVIDHHRI
110 120 130 140 150
ANFETSDPLY YRAEPVGCTA TILNKLYKEN GVEIKKDIAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE EDVKAAKELA AIAGVDADSY GLDMLKAGAD LSAKTIPQLL
210 220 230 240 250
SLDAKEFTMG SHKVEIAQVN TVDTNDVLSR KEEVDAELAK AVSEKGLDLF
260 270 280 290 300
VFVVTDILTN DSVVVASGQA AQAVEKAFNV TLADNTATLK GVVSRKKQIV

PPLTEALKG
Length:309
Mass (Da):33,460
Last modified:October 25, 2004 - v1
Checksum:i6FF52F4F16F88853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU25322.1
AE017333 Genomic DNA Translation: AAU42696.1
RefSeqiWP_003185920.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU25322; AAU25322; BL02502
AAU42696; AAU42696; BLi03882
GeneIDi3027962
KEGGibld:BLi03882
bli:BL02502
PATRICifig|279010.13.peg.3951

Similar proteinsi

Entry informationi

Entry nameiPPAC_BACLD
AccessioniPrimary (citable) accession number: Q65E18
Secondary accession number(s): Q62PI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health