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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 7915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei104 – 10415-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei194 – 1941Uracil; via amide nitrogenUniRule annotation
Binding sitei200 – 20015-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3887-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:BLi03934, BL03992
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Uracil phosphoribosyltransferasePRO_1000053677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL03992.

Structurei

3D structure databases

ProteinModelPortaliQ65DW6.
SMRiQ65DW6. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 13995-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni199 – 2013Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiTIEGWCG.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65DW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVYVFDHP LIQHKLTYIR DVKTGTKEFR ELVDEVATLM AFEITRDLPL
60 70 80 90 100
EEVNVETPVQ MAKSNVIAGK KLGVVPILRA GLGMVDGILK LIPAAKVGHV
110 120 130 140 150
GLYRDPETLK PVEYYVKLPS DVEEREFIVV DPMLATGGSA VEALNSLKKR
160 170 180 190 200
GAKNIRFMCL IAAPEGVDEV QKHHPDVDIY IAALDEKLNE KGYIVPGLGD

AGDRMFGTK
Length:209
Mass (Da):23,039
Last modified:October 25, 2004 - v1
Checksum:iA542FBC2D3F1EBBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25373.1.
AE017333 Genomic DNA. Translation: AAU42748.1.
RefSeqiYP_006715211.1. NC_006322.1.
YP_081011.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU25373; AAU25373; BL03992.
AAU42748; AAU42748; BLi03934.
GeneIDi3028298.
3101272.
KEGGibld:BLi03934.
bli:BL03992.
PATRICi18953660. VBIBacLic203714_4005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25373.1.
AE017333 Genomic DNA. Translation: AAU42748.1.
RefSeqiYP_006715211.1. NC_006322.1.
YP_081011.1. NC_006270.3.

3D structure databases

ProteinModelPortaliQ65DW6.
SMRiQ65DW6. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BL03992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25373; AAU25373; BL03992.
AAU42748; AAU42748; BLi03934.
GeneIDi3028298.
3101272.
KEGGibld:BLi03934.
bli:BL03992.
PATRICi18953660. VBIBacLic203714_4005.

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiTIEGWCG.
OrthoDBiEOG6HF5WX.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00636.
BioCyciBLIC279010:GJ2P-3887-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiUPP_BACLD
AccessioniPrimary (citable) accession number: Q65DW6
Secondary accession number(s): Q62PD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.