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Q65DW6

- UPP_BACLD

UniProt

Q65DW6 - UPP_BACLD

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 7915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei104 – 10415-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei194 – 1941Uracil; via amide nitrogenUniRule annotation
    Binding sitei200 – 20015-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-3887-MONOMER.
    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:BLi03934, BL03992
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Uracil phosphoribosyltransferasePRO_1000053677Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL03992.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65DW6.
    SMRiQ65DW6. Positions 2-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 13995-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni199 – 2013Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    HOGENOMiHOG000262754.
    KOiK00761.
    OMAiTIEGWCG.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65DW6-1 [UniParc]FASTAAdd to Basket

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    MGKVYVFDHP LIQHKLTYIR DVKTGTKEFR ELVDEVATLM AFEITRDLPL    50
    EEVNVETPVQ MAKSNVIAGK KLGVVPILRA GLGMVDGILK LIPAAKVGHV 100
    GLYRDPETLK PVEYYVKLPS DVEEREFIVV DPMLATGGSA VEALNSLKKR 150
    GAKNIRFMCL IAAPEGVDEV QKHHPDVDIY IAALDEKLNE KGYIVPGLGD 200
    AGDRMFGTK 209
    Length:209
    Mass (Da):23,039
    Last modified:October 25, 2004 - v1
    Checksum:iA542FBC2D3F1EBBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000002 Genomic DNA. Translation: AAU25373.1.
    AE017333 Genomic DNA. Translation: AAU42748.1.
    RefSeqiYP_006715211.1. NC_006322.1.
    YP_081011.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU25373; AAU25373; BL03992.
    AAU42748; AAU42748; BLi03934.
    GeneIDi3028298.
    3101272.
    KEGGibld:BLi03934.
    bli:BL03992.
    PATRICi18953660. VBIBacLic203714_4005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000002 Genomic DNA. Translation: AAU25373.1 .
    AE017333 Genomic DNA. Translation: AAU42748.1 .
    RefSeqi YP_006715211.1. NC_006322.1.
    YP_081011.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65DW6.
    SMRi Q65DW6. Positions 2-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL03992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU25373 ; AAU25373 ; BL03992 .
    AAU42748 ; AAU42748 ; BLi03934 .
    GeneIDi 3028298.
    3101272.
    KEGGi bld:BLi03934.
    bli:BL03992.
    PATRICi 18953660. VBIBacLic203714_4005.

    Phylogenomic databases

    eggNOGi COG0035.
    HOGENOMi HOG000262754.
    KOi K00761.
    OMAi TIEGWCG.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .
    BioCyci BLIC279010:GJ2P-3887-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiUPP_BACLD
    AccessioniPrimary (citable) accession number: Q65DW6
    Secondary accession number(s): Q62PD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3