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Q65DU6

- KITH_BACLD

UniProt

Q65DU6 - KITH_BACLD

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Protein

Thymidine kinase

Gene
tdk, BLi03954, BL03975
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor Reviewed prediction
Metal bindingi145 – 1451Zinc By similarity
Metal bindingi148 – 1481Zinc By similarity
Metal bindingi183 – 1831Zinc By similarity
Metal bindingi186 – 1861Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarity
Nucleotide bindingi88 – 914ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-3907-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:BLi03954, BL03975
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Thymidine kinaseUniRule annotationPRO_0000174961Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL03975.

Structurei

3D structure databases

ProteinModelPortaliQ65DU6.
SMRiQ65DU6. Positions 1-191.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65DU6-1 [UniParc]FASTAAdd to Basket

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MYIMKQSGWL ELICGSMFSG KSEELIRRIK RATFAKQEVK VFKPAIDNRY    50
SSESVVSHNG TSIVCHAIAS PEEIFQYISK ETDVIGVDEV QFFDETIVGT 100
LTSLADQGYR VIAAGLDLDF RGEPFGVVPD LMALAETVTK LQAVCSVCGS 150
PASRTQRLIN GKPASYDDPV ILVGASEAYE ARCRHHHEVP GNPK 194
Length:194
Mass (Da):21,298
Last modified:October 25, 2004 - v1
Checksum:iCF99EAE939FD14A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU42768.1.
CP000002 Genomic DNA. Translation: AAU25393.1.
RefSeqiYP_006715231.1. NC_006322.1.
YP_081031.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU25393; AAU25393; BL03975.
AAU42768; AAU42768; BLi03954.
GeneIDi3027778.
3101344.
KEGGibld:BLi03954.
bli:BL03975.
PATRICi18953702. VBIBacLic203714_4026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU42768.1 .
CP000002 Genomic DNA. Translation: AAU25393.1 .
RefSeqi YP_006715231.1. NC_006322.1.
YP_081031.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65DU6.
SMRi Q65DU6. Positions 1-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL03975.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU25393 ; AAU25393 ; BL03975 .
AAU42768 ; AAU42768 ; BLi03954 .
GeneIDi 3027778.
3101344.
KEGGi bld:BLi03954.
bli:BL03975.
PATRICi 18953702. VBIBacLic203714_4026.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-3907-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiKITH_BACLD
AccessioniPrimary (citable) accession number: Q65DU6
Secondary accession number(s): Q62PB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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