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Q65DJ9

- THIM_BACLD

UniProt

Q65DJ9 - THIM_BACLD

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, BLi04052, BL03865
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate; via amide nitrogen By similarity
Binding sitei121 – 1211ATP By similarity
Binding sitei167 – 1671ATP By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-4007-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:BLi04052, BL03865
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Hydroxyethylthiazole kinaseUniRule annotation
PRO_1000021501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL03865.

Structurei

3D structure databases

ProteinModelPortaliQ65DJ9.
SMRiQ65DJ9. Positions 1-268.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65DJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MNMEDAARGI ELVRKQKPLV HNMTNNVVTN FTANGLLALG ASPVMAYARE    50
EAADMAKIAG ALVLNIGTLS RESVEAMIIA GKSANEHGVP VIFDPVGAGA 100
TPFRTESAQA IMRKVKVSAV RGNAAEIANT LGEDWLIKGV DAGEESGDRT 150
ELAKKAAKLW DTAVIITGAE DVITDGTKTY TVGNGHQLLT KVTGTGCLFT 200
SVIGAFCAVE KDVCRAAVSA AAFYGTAAEL AAAKTESRGP GSFQIEFLNQ 250
LAAVEAMDIK ERGRIREVE 269
Length:269
Mass (Da):28,240
Last modified:October 25, 2004 - v1
Checksum:iDB464AB32443BCE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000002 Genomic DNA. Translation: AAU25492.1.
AE017333 Genomic DNA. Translation: AAU42865.1.
RefSeqiYP_006715329.1. NC_006322.1.
YP_081130.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU25492; AAU25492; BL03865.
AAU42865; AAU42865; BLi04052.
GeneIDi3030181.
3099156.
KEGGibld:BLi04052.
bli:BL03865.
PATRICi18953914. VBIBacLic203714_4132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000002 Genomic DNA. Translation: AAU25492.1 .
AE017333 Genomic DNA. Translation: AAU42865.1 .
RefSeqi YP_006715329.1. NC_006322.1.
YP_081130.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65DJ9.
SMRi Q65DJ9. Positions 1-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL03865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU25492 ; AAU25492 ; BL03865 .
AAU42865 ; AAU42865 ; BLi04052 .
GeneIDi 3030181.
3099156.
KEGGi bld:BLi04052.
bli:BL03865.
PATRICi 18953914. VBIBacLic203714_4132.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci BLIC279010:GJ2P-4007-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiTHIM_BACLD
AccessioniPrimary (citable) accession number: Q65DJ9
Secondary accession number(s): Q62P19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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