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Protein

D-alanine--poly(phosphoribitol) ligase subunit 1

Gene

dltA

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathwayi: lipoteichoic acid biosynthesis

This protein is involved in the pathway lipoteichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoteichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-4034-MONOMER.
UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1UniRule annotation (EC:6.1.1.13UniRule annotation)
Alternative name(s):
D-alanine-D-alanyl carrier protein ligaseUniRule annotation
Short name:
DCLUniRule annotation
D-alanine-activating enzymeUniRule annotation
Short name:
DAEUniRule annotation
Gene namesi
Name:dltAUniRule annotation
Ordered Locus Names:BLi04080, BL03934
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502D-alanine--poly(phosphoribitol) ligase subunit 1PRO_1000025529Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi04080.

Structurei

3D structure databases

ProteinModelPortaliQ65DH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IQD. Bacteria.
COG1020. LUCA.
HOGENOMiHOG000229995.
KOiK03367.
OMAiDEMLATC.
OrthoDBiEOG6QP0WP.

Family and domain databases

HAMAPiMF_00593. DltA.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65DH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIETIKKY AQTQPDTLAF VNEEEKLTYG ELWSQSERLA ARIQSEALTD
60 70 80 90 100
ASPIIVYGHM KPVMAVSFLA CVKAGHPYIP VDVSIPADRI LKIINSSKAE
110 120 130 140 150
LLLNNSGTSV DTGDALISVV EPGVLEGDGV PETDPGRWVH GEDTFYIIYT
160 170 180 190 200
SGSTGNPKGV QISADNLQSF TDWITNDFPV ESGQVFLNQA PFSFDLSVMD
210 220 230 240 250
LYPCLQSGGT LWTVTKDMIN RPKLLFEALK QSNVNVWTST PSFAQMCLMD
260 270 280 290 300
PSYSEELLPE LSLFMFCGET LPASVARQLK ERFPKARVFN TYGPTEATVA
310 320 330 340 350
VTSIEVTDDV LNKYSSLPVG SEKPETEIVI INEDGKAVQD GEKGEIIITG
360 370 380 390 400
ASVSKGYLGE KALTEKAFFS YNGSPAYRTG DAGYKENGQL FFLGRLDFQI
410 420 430 440 450
KLHGYRIELE EIEYQINQSR YVQSAVVIPF YREEKIEYLI AMIVPAEHDF
460 470 480 490 500
EKEYQLTSAI KKDLGSKLPA YMIPRKFMYQ KEIPMTANGK IDRKRLKEEV

TV
Length:502
Mass (Da):56,010
Last modified:October 25, 2004 - v1
Checksum:iFCBF40EA617BC2B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25520.1.
AE017333 Genomic DNA. Translation: AAU42893.1.
RefSeqiWP_003186280.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU25520; AAU25520; BL03934.
AAU42893; AAU42893; BLi04080.
GeneIDi3028795.
KEGGibld:BLi04080.
bli:BL03934.
PATRICi18953974. VBIBacLic203714_4162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU25520.1.
AE017333 Genomic DNA. Translation: AAU42893.1.
RefSeqiWP_003186280.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65DH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi04080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25520; AAU25520; BL03934.
AAU42893; AAU42893; BLi04080.
GeneIDi3028795.
KEGGibld:BLi04080.
bli:BL03934.
PATRICi18953974. VBIBacLic203714_4162.

Phylogenomic databases

eggNOGiENOG4108IQD. Bacteria.
COG1020. LUCA.
HOGENOMiHOG000229995.
KOiK03367.
OMAiDEMLATC.
OrthoDBiEOG6QP0WP.

Enzyme and pathway databases

UniPathwayiUPA00556.
BioCyciBLIC279010:GJ2P-4034-MONOMER.

Family and domain databases

HAMAPiMF_00593. DltA.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiDLTA_BACLD
AccessioniPrimary (citable) accession number: Q65DH1
Secondary accession number(s): Q62NZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: January 20, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.