Q65D22 (DEOC2_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 2
Short name=DERA 2
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 2
Phosphodeoxyriboaldolase 2
Short name=Deoxyriboaldolase 2

Gene names

Name:	deoC2
Synonyms:	deoC, dra
Ordered Locus Names:	BLi04229, BL00229

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase 2 HAMAP MF_00114		PRO_0000231532
Sites
	Active site	152	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	181	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65D22 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 4FDB3D4DE04452AB	FASTA	223	23,456
	10 20 30 40 50 60 MTIANLIDHT ALKPHTQKSE IKKLIEEAKA YQFASVCVNP TWVEFAAEEL KGTEIDVCTV 70 80 90 100 110 120 IGFPLGANTT ETKAFETKDA IAKGATEVDM VINIAALKDG NDDFVEADIR AVVEAAKGKA 130 140 150 160 170 180 LVKVIIETCL LTDEEKERAC RLAVAAGADF VKTSTGFSTG GATAEDIALM RKTVGPDIGV 190 200 210 220 KASGGIRTKE DVETMISNGA TRIGASAGVS IVSGAEGKNE DNY

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU43042.1. CP000002 Genomic DNA. Translation: AAU25663.1.
RefSeq	YP_081301.1. NC_006270.3. YP_093735.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65D22.
SMR	Q65D22. Positions 3-218.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65D22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000055542; EBBACP00000054073; EBBACG00000055533. EBBACT00000060560; EBBACP00000058993; EBBACG00000060551.
GeneID	3031406. 3100763.
GenomeReviews	Gene locus BLi04229 in contig AE017333_GR. Gene locus BL00229 in contig CP000002_GR.
KEGG	bld:BLi04229. bli:BL00229.
NMPDR	fig|279010.5.peg.3883.
PATRIC	18954284. VBIBacLic203714_4317.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
GeneTree	EBGT00050000000908.
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	Q65D22.
ProtClustDB	CLSK929138.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI04229-MONOMER. BLIC279010:BL00229-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC2_BACLD

Accession

Primary (citable) accession number: Q65D22
Secondary accession number(s): Q62NJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program