Q65D06 (IOLG_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
EC=1.1.1.18
EC=1.1.1.n6

Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	BLi04245, BL00240

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352557

Sequences

	Sequence		Length	Mass (Da)
	Q65D06 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: E38043FCDC23589C	FASTA	344	38,134
	10 20 30 40 50 60 MKLRIGVIGT GAIGKEHINR ITNKLAGGEI VAVTDVNQEA AQQVVTDYSL NAKVYPDDDS 70 80 90 100 110 120 LIAAENVDAV LVTSWGPAHE SSVLKAIKAN KFVFCEKPLA TTAEGCMRIV NEEVKAGKRL 130 140 150 160 170 180 VQVGFMRRYD SGYVQLKEAI DNRVIGEPLM IHCAHRNPVV GDNYTTDMAV VDTLVHEIDA 190 200 210 220 230 240 LHWLINDDYE SVQVIYPKKS KNALPHLRDP QIVIIETKGG VVINAEIYVN CKYGYDIQCE 250 260 270 280 290 300 IVGEDGIVKL PEPSSISLRK DGKFSTDILM DWQRRFVDAY DVEIQDFIDS IQQKGEVSGP 310 320 330 340 TAWDGYIAAV TTDACVKAQE SGQKEPVALQ EKPEFYQTFT TVKK

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000002 Genomic DNA. Translation: AAU25679.1. AE017333 Genomic DNA. Translation: AAU43058.1.
RefSeq	YP_081317.1. NC_006270.3. YP_093751.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65D06.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65D06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000054694; EBBACP00000053225; EBBACG00000054685. EBBACT00000061111; EBBACP00000059544; EBBACG00000061102.
GeneID	3030905. 3097399.
GenomeReviews	Gene locus BLi04245 in contig AE017333_GR. Gene locus BL00240 in contig CP000002_GR.
KEGG	bld:BLi04245. bli:BL00240.
NMPDR	fig|279010.5.peg.4024.
PATRIC	18954316. VBIBacLic203714_4333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
GeneTree	EBGT00050000000829.
HOGENOM	HBG612336.
OMA	HINRITN.
ProtClustDB	CLSK873287.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI04245-MONOMER. BLIC279010:BL00240-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BACLD

Accession

Primary (citable) accession number: Q65D06
Secondary accession number(s): Q62NI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program