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Protein

Sulfate transporter

Gene

SLC26A2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Solute carrier family 26 member 2
Gene namesi
Name:SLC26A2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50000726381 – 736Sulfate transporterAdd BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ65AC2
PRIDEiQ65AC2

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020821

Structurei

3D structure databases

ProteinModelPortaliQ65AC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini570 – 721STASPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
HOGENOMiHOG000006546
InParanoidiQ65AC2
KOiK14701

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030280 SLC26A2
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF16 PTHR11814:SF16, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 2 hits
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q65AC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSESKEPHV LSPKDSFEGN DRYSPPSRIH LELEKKSSTD FKQFEASEPC
60 70 80 90 100
RPYPRIHMEP QEKSNTNFKQ FVIKKLQKSC QCSPTKAKNM IFGFLPVLQW
110 120 130 140 150
LPKYDLKKNI LGDVMSGLIV GILLVPQSIA YSLLAGQEPI YGLYTSFFAS
160 170 180 190 200
LIYFLLGTSR HISVGIFGVL CLMIGEVVDR ELLKAGYDTV HIAPSLGMVS
210 220 230 240 250
NGSTSLNQTS DRICDRSCYA IKVGSTVTFL AGIYQVAMGF FQVGFVSVYL
260 270 280 290 300
SDALLSGFVT GASFTILTSQ AKYLLGLSLP RSSGVGSLIT TWIHIFRNIH
310 320 330 340 350
KTNVCDLITS LLCLLVLLPT KELNEHFKSK LKAPIPTELV VVVAATLASH
360 370 380 390 400
FGKLHEKYNT SIAGHIPTGF MPPKAPDWNL IPSVAVDAIA ISIIGFAITV
410 420 430 440 450
SLSEMFAKKH GYTVKANQEM YAIGFCNIIP SFFHCFTTSA ALAKTLVKES
460 470 480 490 500
TGCQSQLSGV MTALVLLLVL LVIAPLFYSL QKSVLGVITI VNLRGALRKF
510 520 530 540 550
RDLPKMWRVS RMDTVIWFVT MLSSALISTE LGLLIGVCFS MFCVILRTQK
560 570 580 590 600
PKVSLLGLVE ETEIFESMSA YKNLQARPGI KIFRFVAPLY YINKECFKSA
610 620 630 640 650
LYKKTLNPVL VKAAQKKAAK RKIKKQPVTL SGIQNEISVQ LSHDPLELRT
660 670 680 690 700
IVIDCSAIQF LDTAGIHTLK EVRRDYEAIG IQVLLAQCNP SVRDSLARGE
710 720 730
YCKDEEENLL FYSVYEAMAF AEESQNQKGI CIPNGL
Length:736
Mass (Da):81,489
Last modified:October 25, 2004 - v1
Checksum:iCB81CA27F63B940F
GO

Sequence cautioni

The sequence CAG27693 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ698508 mRNA Translation: CAG27404.1
AJ698728 Genomic DNA Translation: CAG27563.1
AJ698944 Genomic DNA Translation: CAG27693.1 Sequence problems.
RefSeqiNP_001075403.1, NM_001081934.2
XP_005599193.1, XM_005599136.2
XP_005599194.1, XM_005599137.2
UniGeneiEca.12728

Genome annotation databases

GeneIDi100034141
KEGGiecb:100034141

Similar proteinsi

Entry informationi

Entry nameiS26A2_HORSE
AccessioniPrimary (citable) accession number: Q65AC2
Secondary accession number(s): Q4W444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health