Q65A08 (Q65A08_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Mannonate dehydratase 2 HAMAP MF_00106
EC=4.2.1.8 HAMAP MF_00106

Alternative name(s):
D-mannonate hydrolase 2 HAMAP MF_00106

Gene names

Name:	uxuA EMBL CAH55786.1
Synonyms:	uxuA2 HAMAP MF_00106
ORF Names:	eco0009 EMBL CAH55786.1, ECs5281 EMBL ACI72946.1, LF82_2403 EMBL CAP78802.1

Organism

Escherichia coli EMBL CAH55786.1

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. SAAS SAAS004628 HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. SAAS SAAS004628 HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family. HAMAP MF_00106

Ontologies

Keywords
Molecular function	Hydrolase EMBL CAH55786.1 Lyase SAAS SAAS004628 HAMAP MF_00106
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q65A08 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 49CCE5DB9599B735	FASTA	394	44,824
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLADVR QAGATGVVTA LHHIPNGEVW SVEEILKRKA IVEDAGLVWS 70 80 90 100 110 120 VVESVPIHED IKTHTGNYEQ WIANYQQTLR NLAQCGIRTV CYNFMPVLDW TRTDLEYVLP 130 140 150 160 170 180 DGSKALRFDQ IEFAAFEMHI LKRPGAEADY TEEEIAQAAE RFATMSDEDK ARLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DQFRKHLELY KDIDKAKLRE NFAVFLKAII PVAEEVGVRM AVHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWMVDT VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR 310 320 330 340 350 360 STMREDNPKT FHEAAHLNGD VDMYEVVKAI VEEEHRRKAE GKEDLIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSR

References

[1]	"A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis." Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J., Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E., Sawyer S.A., Whittam T.S., Tarr P.I. Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009) [PubMed: 19439656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 493/89 EMBL ACI72946.1 and TB182A EMBL ACI72949.1.
[2]	"Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83 : K24 : H31)." Hejnova A., Dobrindt U., Nemcova R., Rusniok C., Bomba A., Frangeul L., Hacker J., Glaser P., Sebo P., Buchrieser C. Microbiology (Mosc.) 151:385-398(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: CNCTC Ec 325/71 EMBL CAH55786.1.
[3]	"Complete genome sequence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease." Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B., Segurens B., Peyret P., Darfeuille-Michaud A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: LF82 EMBL CAP78802.1.
[4]	Genoscope - CEA Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: LF82 EMBL CAP78802.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU890360 Genomic DNA. Translation: ACI72946.1. EU890363 Genomic DNA. Translation: ACI72949.1. AJ829704 Genomic DNA. Translation: CAH55786.1. CU651637 Genomic DNA. Translation: CAP78802.1.
3D structure databases
ProteinModelPortal	Q65A08.
SMR	Q65A08. Positions 1-389.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	48658985. VBIEscCol74806_4460.
Phylogenomic databases
HOGENOM	HBG585927.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q65A08_ECOLX

Accession

Primary (citable) accession number: Q65A08

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)