Q659C4 (LAR1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
La-related protein 1B

Alternative name(s):
La ribonucleoprotein domain family member 1B
La ribonucleoprotein domain family member 2
La-related protein 2

Gene names

Name:	LARP1B
Synonyms:	LARP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	914 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the LARP family. Contains 1 HTH La-type RNA-binding domain.
Sequence caution	The sequence AAH50654.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH50654.1 differs from that shown. Reason: Frameshift at position 753. The sequence BAB15679.1 differs from that shown. Reason: Frameshift at position 721. The sequence CAH56379.1 differs from that shown. Reason: Frameshift at position 113.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q659C4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q659C4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-120: ANKHKWVPLHLDVVRSESQERPGSRNSSRCQPEANKPTHNNRRNDTRS → G
     550-561: Missing.

Isoform 3 (identifier: Q659C4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     330-335: ESAPNS → VRVMIF
     336-914: Missing.

Isoform 4 (identifier: Q659C4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.
     509-522: QEVENFKKLNLISK → VIVSGQHLSTDALF
     523-914: Missing.

Isoform 5 (identifier: Q659C4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-581: Missing.
     850-914: PPISDEFGRK...ISPESSDNSH → NHHDRLLLLIINI

Isoform 6 (identifier: Q659C4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-654: Missing.
     896-914: VPINSPRRNISPESSDNSH → EADPIE

Isoform 7 (identifier: Q659C4-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-654: Missing.
     850-914: PPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSPRRNISPESSDNSH → EADPIE

Isoform 8 (identifier: Q659C4-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-790: Missing.
     791-806: EIFQDFQEETKKDYES → MRNLDNLLGKMQKKIT

Isoform 9 (identifier: Q659C4-9)

The sequence of this isoform differs from the canonical sequence as follows:
     771-787: YGLECLFRFYSYGLEKK → SAVWTRKVLGLFEIFSI
     788-914: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 914	914	La-related protein 1B		PRO_0000299411
Regions
	Domain	209 – 299	91	HTH La-type RNA-binding
	Compositional bias	114 – 167	54	Arg-rich
Amino acid modifications
	Modified residue	60	1	Phosphoserine Ref.5 Ref.6 Ref.8
	Modified residue	340	1	Phosphoserine Ref.5 Ref.6
	Modified residue	343	1	Phosphoserine Ref.5 Ref.6
	Modified residue	363	1	Phosphoserine Ref.7
	Modified residue	432	1	Phosphoserine Ref.8
	Modified residue	454	1	Phosphothreonine Ref.6
Natural variations
	Alternative sequence	1 – 790	790	Missing in isoform 8.		VSP_027638
	Alternative sequence	1 – 654	654	Missing in isoform 6 and isoform 7.		VSP_027639
	Alternative sequence	1 – 581	581	Missing in isoform 5.		VSP_027640
	Alternative sequence	1 – 194	194	Missing in isoform 4.		VSP_027641
	Alternative sequence	73 – 120	48	ANKHK…NDTRS → G in isoform 2.		VSP_027642
	Alternative sequence	330 – 335	6	ESAPNS → VRVMIF in isoform 3.		VSP_027643
	Alternative sequence	336 – 914	579	Missing in isoform 3.		VSP_027644
	Alternative sequence	509 – 522	14	QEVEN…NLISK → VIVSGQHLSTDALF in isoform 4.		VSP_027645
	Alternative sequence	523 – 914	392	Missing in isoform 4.		VSP_027646
	Alternative sequence	550 – 561	12	Missing in isoform 2.		VSP_027647
	Alternative sequence	771 – 787	17	YGLEC…GLEKK → SAVWTRKVLGLFEIFSI in isoform 9.		VSP_027648
	Alternative sequence	788 – 914	127	Missing in isoform 9.		VSP_027649
	Alternative sequence	791 – 806	16	EIFQD…KDYES → MRNLDNLLGKMQKKIT in isoform 8.		VSP_027650
	Alternative sequence	850 – 914	65	PPISD…SDNSH → NHHDRLLLLIINI in isoform 5.		VSP_027651
	Alternative sequence	850 – 914	65	PPISD…SDNSH → EADPIE in isoform 7.		VSP_027652
	Alternative sequence	896 – 914	19	VPINS…SDNSH → EADPIE in isoform 6.		VSP_027653
	Natural variant	462	1	P → R. Ref.1 Ref.2 Corresponds to variant rs12508837 [ dbSNP | Ensembl ].		VAR_034813
	Natural variant	660	1	R → H. Ref.2 Ref.4 Corresponds to variant rs12645577 [ dbSNP | Ensembl ].		VAR_034814
Experimental info
	Sequence conflict	272	1	A → V in BAC03970. Ref.1
	Sequence conflict	289	1	K → E in BAA91576. Ref.1
	Sequence conflict	291	1	E → T in BAC05306. Ref.1
	Sequence conflict	473	1	R → Q in BAC03970. Ref.1
	Sequence conflict	639	1	T → A in CAD97908. Ref.2
	Sequence conflict	671	1	N → S in AAH62606. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: A06968F316A432BC	FASTA	914	105,322
	10 20 30 40 50 60 MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS 70 80 90 100 110 120 EDEAQSSNQR KRANKHKWVP LHLDVVRSES QERPGSRNSS RCQPEANKPT HNNRRNDTRS 130 140 150 160 170 180 WKRDREKRDD QDDVSSVRSE GGNIRGSFRG RGRGRGRGRG RGRGNPRLNF DYSYGYQEHG 190 200 210 220 230 240 ERTDQPFQTE LNTSMMYYYD DGTGVQVYPV EEALLKEYIK RQIEYYFSVE NLERDFFLRG 250 260 270 280 290 300 KMDEQGFLPI SLIAGFQRVQ ALTTNLNLIL EALKDSTEVE IVDEKMRKKI EPEKWPIPGP 310 320 330 340 350 360 PPRSVPPTDF SQLIDCPEFV PGQAFCSHTE SAPNSPRIGS PLSPKKNSET SILQAMSRGL 370 380 390 400 410 420 STSLPDLDSE PWIEVKKRHQ PAPVKLRESV SVPEGSLNQL CSSEEPEQEE LDFLFDEEIE 430 440 450 460 470 480 QIGRKNTFTD WSDNDSDYEI DDQDLNKILI VTQTPPYVKK HPGGDRTGTH MSRAKITSEL 490 500 510 520 530 540 AKVINDGLYY YEQDLWMEED ENKHTAIKQE VENFKKLNLI SKEQFENLTP ELPFEPNQEV 550 560 570 580 590 600 PVAPSQSRQG GVQGVLHIPK KDLTDELAQK LFDVSEITSA AMVHSLPTAV PESPRIHPTR 610 620 630 640 650 660 TPKTPRTPRL QDPNKTPRFY PVVKEPKAID VKSPRKRKTR HSTNPPLECH VGWVMDSRDR 670 680 690 700 710 720 GPGTSSVSTS NASPSEGAPL AGSYGCTPHS FPKFQHPSHE LLKENGFTQQ VYHKYRRRCL 730 740 750 760 770 780 SERKRLGIGQ SQEMNTLFRF WSFFLRDHFN KKMYEEFRQL AWEDAKENYR YGLECLFRFY 790 800 810 820 830 840 SYGLEKKFRR EIFQDFQEET KKDYESGQLY GLEKFWAYLK YSQSKTQSID PKLQEYLCSF 850 860 870 880 890 900 KRLEDFRVDP PISDEFGRKR HSSTSGEESN RHRLPPNSST KPPNAAKPTS TSELQVPINS 910 PRRNISPESS DNSH
	Isoform 2 [UniParc]. Checksum: 0F0C4F2E5FDB77C5	FASTA	855	98,592
	10 20 30 40 50 60 MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS 70 80 90 100 110 120 EDEAQSSNQR KRGWKRDREK RDDQDDVSSV RSEGGNIRGS FRGRGRGRGR GRGRGRGNPR 130 140 150 160 170 180 LNFDYSYGYQ EHGERTDQPF QTELNTSMMY YYDDGTGVQV YPVEEALLKE YIKRQIEYYF 190 200 210 220 230 240 SVENLERDFF LRGKMDEQGF LPISLIAGFQ RVQALTTNLN LILEALKDST EVEIVDEKMR 250 260 270 280 290 300 KKIEPEKWPI PGPPPRSVPP TDFSQLIDCP EFVPGQAFCS HTESAPNSPR IGSPLSPKKN 310 320 330 340 350 360 SETSILQAMS RGLSTSLPDL DSEPWIEVKK RHQPAPVKLR ESVSVPEGSL NQLCSSEEPE 370 380 390 400 410 420 QEELDFLFDE EIEQIGRKNT FTDWSDNDSD YEIDDQDLNK ILIVTQTPPY VKKHPGGDRT 430 440 450 460 470 480 GTHMSRAKIT SELAKVINDG LYYYEQDLWM EEDENKHTAI KQEVENFKKL NLISKEQFEN 490 500 510 520 530 540 LTPELPFEPN QEVPVAPSQS RQDLTDELAQ KLFDVSEITS AAMVHSLPTA VPESPRIHPT 550 560 570 580 590 600 RTPKTPRTPR LQDPNKTPRF YPVVKEPKAI DVKSPRKRKT RHSTNPPLEC HVGWVMDSRD 610 620 630 640 650 660 RGPGTSSVST SNASPSEGAP LAGSYGCTPH SFPKFQHPSH ELLKENGFTQ QVYHKYRRRC 670 680 690 700 710 720 LSERKRLGIG QSQEMNTLFR FWSFFLRDHF NKKMYEEFRQ LAWEDAKENY RYGLECLFRF 730 740 750 760 770 780 YSYGLEKKFR REIFQDFQEE TKKDYESGQL YGLEKFWAYL KYSQSKTQSI DPKLQEYLCS 790 800 810 820 830 840 FKRLEDFRVD PPISDEFGRK RHSSTSGEES NRHRLPPNSS TKPPNAAKPT STSELQVPIN 850 SPRRNISPES SDNSH
	Isoform 3 [UniParc]. Checksum: C9C6E17E4B69EDC0	FASTA	335	38,760
	10 20 30 40 50 60 MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS 70 80 90 100 110 120 EDEAQSSNQR KRANKHKWVP LHLDVVRSES QERPGSRNSS RCQPEANKPT HNNRRNDTRS 130 140 150 160 170 180 WKRDREKRDD QDDVSSVRSE GGNIRGSFRG RGRGRGRGRG RGRGNPRLNF DYSYGYQEHG 190 200 210 220 230 240 ERTDQPFQTE LNTSMMYYYD DGTGVQVYPV EEALLKEYIK RQIEYYFSVE NLERDFFLRG 250 260 270 280 290 300 KMDEQGFLPI SLIAGFQRVQ ALTTNLNLIL EALKDSTEVE IVDEKMRKKI EPEKWPIPGP 310 320 330 PPRSVPPTDF SQLIDCPEFV PGQAFCSHTV RVMIF
	Isoform 4 [UniParc]. Checksum: AE95BD2DD32EF435	FASTA	328	37,423
	10 20 30 40 50 60 MMYYYDDGTG VQVYPVEEAL LKEYIKRQIE YYFSVENLER DFFLRGKMDE QGFLPISLIA 70 80 90 100 110 120 GFQRVQALTT NLNLILEALK DSTEVEIVDE KMRKKIEPEK WPIPGPPPRS VPPTDFSQLI 130 140 150 160 170 180 DCPEFVPGQA FCSHTESAPN SPRIGSPLSP KKNSETSILQ AMSRGLSTSL PDLDSEPWIE 190 200 210 220 230 240 VKKRHQPAPV KLRESVSVPE GSLNQLCSSE EPEQEELDFL FDEEIEQIGR KNTFTDWSDN 250 260 270 280 290 300 DSDYEIDDQD LNKILIVTQT PPYVKKHPGG DRTGTHMSRA KITSELAKVI NDGLYYYEQD 310 320 LWMEEDENKH TAIKVIVSGQ HLSTDALF
	Isoform 5 [UniParc]. Checksum: FCEA078CC09712CD	FASTA	281	33,365
	10 20 30 40 50 60 MVHSLPTAVP ESPRIHPTRT PKTPRTPRLQ DPNKTPRFYP VVKEPKAIDV KSPRKRKTRH 70 80 90 100 110 120 STNPPLECHV GWVMDSRDRG PGTSSVSTSN ASPSEGAPLA GSYGCTPHSF PKFQHPSHEL 130 140 150 160 170 180 LKENGFTQQV YHKYRRRCLS ERKRLGIGQS QEMNTLFRFW SFFLRDHFNK KMYEEFRQLA 190 200 210 220 230 240 WEDAKENYRY GLECLFRFYS YGLEKKFRRE IFQDFQEETK KDYESGQLYG LEKFWAYLKY 250 260 270 280 SQSKTQSIDP KLQEYLCSFK RLEDFRVDNH HDRLLLLIIN I
	Isoform 6 [UniParc]. Checksum: A588465BD3DFFB00	FASTA	247	29,074
	10 20 30 40 50 60 MDSRDRGPGT SSVSTSNASP SEGAPLAGSY GCTPHSFPKF QHPSHELLKE NGFTQQVYHK 70 80 90 100 110 120 YRRRCLSERK RLGIGQSQEM NTLFRFWSFF LRDHFNKKMY EEFRQLAWED AKENYRYGLE 130 140 150 160 170 180 CLFRFYSYGL EKKFRREIFQ DFQEETKKDY ESGQLYGLEK FWAYLKYSQS KTQSIDPKLQ 190 200 210 220 230 240 EYLCSFKRLE DFRVDPPISD EFGRKRHSST SGEESNRHRL PPNSSTKPPN AAKPTSTSEL QEADPIE
	Isoform 7 [UniParc]. Checksum: B719AE1095269FA0	FASTA	201	24,078
	10 20 30 40 50 60 MDSRDRGPGT SSVSTSNASP SEGAPLAGSY GCTPHSFPKF QHPSHELLKE NGFTQQVYHK 70 80 90 100 110 120 YRRRCLSERK RLGIGQSQEM NTLFRFWSFF LRDHFNKKMY EEFRQLAWED AKENYRYGLE 130 140 150 160 170 180 CLFRFYSYGL EKKFRREIFQ DFQEETKKDY ESGQLYGLEK FWAYLKYSQS KTQSIDPKLQ 190 200 EYLCSFKRLE DFRVDEADPI E
	Isoform 8 [UniParc]. Checksum: ADF0FC1FEAEFB368	FASTA	124	14,193
	10 20 30 40 50 60 MRNLDNLLGK MQKKITGQLY GLEKFWAYLK YSQSKTQSID PKLQEYLCSF KRLEDFRVDP 70 80 90 100 110 120 PISDEFGRKR HSSTSGEESN RHRLPPNSST KPPNAAKPTS TSELQVPINS PRRNISPESS DNSH
	Isoform 9 [UniParc]. Checksum: 53CDFB5EA4C8A79A	FASTA	787	90,405
	10 20 30 40 50 60 MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS 70 80 90 100 110 120 EDEAQSSNQR KRANKHKWVP LHLDVVRSES QERPGSRNSS RCQPEANKPT HNNRRNDTRS 130 140 150 160 170 180 WKRDREKRDD QDDVSSVRSE GGNIRGSFRG RGRGRGRGRG RGRGNPRLNF DYSYGYQEHG 190 200 210 220 230 240 ERTDQPFQTE LNTSMMYYYD DGTGVQVYPV EEALLKEYIK RQIEYYFSVE NLERDFFLRG 250 260 270 280 290 300 KMDEQGFLPI SLIAGFQRVQ ALTTNLNLIL EALKDSTEVE IVDEKMRKKI EPEKWPIPGP 310 320 330 340 350 360 PPRSVPPTDF SQLIDCPEFV PGQAFCSHTE SAPNSPRIGS PLSPKKNSET SILQAMSRGL 370 380 390 400 410 420 STSLPDLDSE PWIEVKKRHQ PAPVKLRESV SVPEGSLNQL CSSEEPEQEE LDFLFDEEIE 430 440 450 460 470 480 QIGRKNTFTD WSDNDSDYEI DDQDLNKILI VTQTPPYVKK HPGGDRTGTH MSRAKITSEL 490 500 510 520 530 540 AKVINDGLYY YEQDLWMEED ENKHTAIKQE VENFKKLNLI SKEQFENLTP ELPFEPNQEV 550 560 570 580 590 600 PVAPSQSRQG GVQGVLHIPK KDLTDELAQK LFDVSEITSA AMVHSLPTAV PESPRIHPTR 610 620 630 640 650 660 TPKTPRTPRL QDPNKTPRFY PVVKEPKAID VKSPRKRKTR HSTNPPLECH VGWVMDSRDR 670 680 690 700 710 720 GPGTSSVSTS NASPSEGAPL AGSYGCTPHS FPKFQHPSHE LLKENGFTQQ VYHKYRRRCL 730 740 750 760 770 780 SERKRLGIGQ SQEMNTLFRF WSFFLRDHFN KKMYEEFRQL AWEDAKENYR SAVWTRKVLG LFEIFSI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 608-914 (ISOFORM 1), VARIANT ARG-462. Tissue: Lung, Small intestine, Teratocarcinoma and Thyroid.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS ARG-462 AND HIS-660. Tissue: Cervix, Rectum tumor and Testis.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 633-914 (ISOFORM 9), VARIANT HIS-660. Tissue: Blood and Brain.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-340 AND SER-343, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-340; SER-343 AND THR-454, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, MASS SPECTROMETRY.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-432, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001240 mRNA. Translation: BAA91576.1. AK027164 mRNA. Translation: BAB15679.1. Frameshift. AK092764 mRNA. Translation: BAC03970.1. AK098437 mRNA. Translation: BAC05306.1. AL137759 mRNA. Translation: CAH56379.1. Frameshift. AL832170 mRNA. Translation: CAH56210.1. BX537937 mRNA. Translation: CAD97908.1. AC096898 Genomic DNA. No translation available. AC099340 Genomic DNA. No translation available. AC108045 Genomic DNA. No translation available. AC114735 Genomic DNA. Translation: AAY41042.1. AC124030 Genomic DNA. Translation: AAY41031.1. BC030516 mRNA. Translation: AAH30516.1. BC050654 mRNA. Translation: AAH50654.1. Sequence problems. BC062606 mRNA. Translation: AAH62606.1. BC110300 mRNA. Translation: AAI10301.1.
IPI	IPI00383949. IPI00855721. IPI00855786. IPI00855812. IPI00855930. IPI00855953. IPI00856120. IPI00940348. IPI00943149.
RefSeq	NP_060548.2. NM_018078.2. NP_115615.2. NM_032239.2. NP_835144.1. NM_178043.1.
UniGene	Hs.657067.
3D structure databases
HSSP	HSSP built from PDB template 2CQK based on UniProtKB Q71RC2.
ProteinModelPortal	Q659C4.
SMR	Q659C4. Positions 209-301.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47319N.
IntAct	Q659C4. 1 interaction.
PTM databases
PhosphoSite	Q659C4.
Polymorphism databases
DMDM	158564329.
Proteomic databases
PRIDE	Q659C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326639; ENSP00000321997; ENSG00000138709.
GeneID	55132.
KEGG	hsa:55132.
UCSC	uc003ifx.1. human. uc003ifz.1. human. uc003iga.1. human. uc003igc.2. human. uc003igf.1. human.
Organism-specific databases
CTD	55132.
GeneCards	GC04P128983.
HGNC	HGNC:24704. LARP1B.
HPA	HPA036280.
neXtProt	NX_Q659C4.
PharmGKB	PA142671565. PA165664174.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10846.
GeneTree	ENSGT00390000000523.
InParanoid	Q659C4.
OMA	YQEHGER.
OrthoDB	EOG4PZJ64.
PhylomeDB	Q659C4.
Gene expression databases
ArrayExpress	Q659C4.
Bgee	Q659C4.
CleanEx	HS_LARP2.
Genevestigator	Q659C4.
Family and domain databases
InterPro	IPR006607. DM15. IPR006630. Lupus_La_RNA-bd. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF05383. La. 1 hit. [Graphical view]
SMART	SM00684. DM15. 3 hits. SM00715. LA. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	58806.

Entry information

Entry name

LAR1B_HUMAN

Accession

Primary (citable) accession number: Q659C4
Secondary accession number(s): Q2YDB6 , Q4W599, Q4W5B2, Q659A0, Q6P5X2, Q7Z3F7, Q86VK7, Q8N6F4, Q8N7H4, Q8NAF2, Q9H5E7, Q9NW12

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.