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Q659A1

- ICE2_HUMAN

UniProt

Q659A1 - ICE2_HUMAN

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Protein

Little elongation complex subunit 2

Gene

ICE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.1 Publication

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase III promoter Source: UniProtKB
  2. snRNA transcription from RNA polymerase III promoter Source: UniProtKB
  3. snRNA transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Little elongation complex subunit 2
Alternative name(s):
Interactor of little elongator complex ELL subunit 2
NMDA receptor-regulated protein 2
Gene namesi
Name:ICE2
Synonyms:BRCC1, NARG2
ORF Names:UNQ3101/PRO10100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:29885. ICE2.

Subcellular locationi

Nucleus 1 Publication
Note: Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

GO - Cellular componenti

  1. Cajal body Source: UniProtKB
  2. histone locus body Source: UniProtKB
  3. transcriptionally active chromatin Source: UniProtKB
  4. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Little elongation complex subunit 2PRO_0000297964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei571 – 5711PhosphoserineBy similarity
Modified residuei573 – 5731PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ659A1.
PaxDbiQ659A1.
PRIDEiQ659A1.

Expressioni

Tissue specificityi

Expressed at low levels in lung and testis.1 Publication

Developmental stagei

Expressed in fetal brain, kidney, liver and lung.1 Publication

Gene expression databases

BgeeiQ659A1.
ExpressionAtlasiQ659A1. baseline and differential.
GenevestigatoriQ659A1.

Organism-specific databases

HPAiHPA039416.
HPA040058.

Interactioni

Subunit structurei

Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.2 Publications

Protein-protein interaction databases

BioGridi122789. 27 interactions.
IntActiQ659A1. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ659A1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ICE2 family.Curated

Phylogenomic databases

eggNOGiNOG73502.
GeneTreeiENSGT00390000006883.
HOVERGENiHBG102042.
InParanoidiQ659A1.
OMAiLMGFFPF.
OrthoDBiEOG7RNJZS.
PhylomeDBiQ659A1.
TreeFamiTF106272.

Family and domain databases

InterProiIPR019535. NARG2_C.
[Graphical view]
PfamiPF10505. NARG2_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q659A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR
60 70 80 90 100
IGENLNASAS SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF
110 120 130 140 150
SQREQRSYVD LLVKYAKIPA NSKAVGINKN DYLQYLDMKK HVNEEVTEFL
160 170 180 190 200
KFLQNSAKKC AQDYNMLSDD ARLFTEKILR ACIEQVKKYS EFYTLHEVTS
210 220 230 240 250
LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ LSKDDIATIE
260 270 280 290 300
TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE
310 320 330 340 350
QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM
360 370 380 390 400
MSKNTSVPVS AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV
410 420 430 440 450
TELETFGVTT TKVSKSPSPA STSTVPNMTD APTAPKAGTT TVAPSAPDIS
460 470 480 490 500
ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE CKNKDDQGFE SCEKVSNSDK
510 520 530 540 550
PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE RPNVLENLDN
560 570 580 590 600
SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS
610 620 630 640 650
SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK
660 670 680 690 700
MQDELLKPIS RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA
710 720 730 740 750
FQKPKGRLPY ELQDYVEDTS EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR
760 770 780 790 800
IETRPRSKKR KKIRRQFPVY VLPKVEYQAC YGVEALTESE LCRLWTESLL
810 820 830 840 850
HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN LFNILQHILK
860 870 880 890 900
KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS
910 920 930 940 950
SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS
960 970 980
HRNPVSMETK SSCLPAQQVE TEGVAPHKRK IT
Length:982
Mass (Da):110,011
Last modified:August 21, 2007 - v2
Checksum:i09B36E742FC77597
GO
Isoform 2 (identifier: Q659A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-73: RIGENLNASASSVENEPAVSSATQ → ESRGVMWTCWLNTQRFLQIPKLLE
     74-982: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:73
Mass (Da):8,572
Checksum:i697BA4B2564D8E2F
GO

Sequence cautioni

The sequence AAH13684.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH20918.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI07428.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence AAQ88910.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.Curated
The sequence BAB13948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721L → P in CAH18700. (PubMed:17974005)Curated
Sequence conflicti316 – 3161S → L in CAH18700. (PubMed:17974005)Curated
Sequence conflicti355 – 3551T → P in CAH56220. (PubMed:17974005)Curated
Sequence conflicti621 – 6211T → S in CAH56220. (PubMed:17974005)Curated
Sequence conflicti753 – 7531T → A in CAH18700. (PubMed:17974005)Curated
Sequence conflicti906 – 9061W → R in BAB13948. (PubMed:14702039)Curated
Sequence conflicti947 – 9471P → S in CAH56197. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 7324RIGEN…SSATQ → ESRGVMWTCWLNTQRFLQIP KLLE in isoform 2. 1 PublicationVSP_041612Add
BLAST
Alternative sequencei74 – 982909Missing in isoform 2. 1 PublicationVSP_041613Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502591 mRNA. Translation: AAQ07460.1.
AY358546 mRNA. Translation: AAQ88910.1. Sequence problems.
CR749852 mRNA. Translation: CAH18700.1. Sequence problems.
BX647873 mRNA. Translation: CAH56197.1.
AK021958 mRNA. Translation: BAB13948.1. Different initiation.
AK055752 mRNA. Translation: BAG51567.1.
AL833122 mRNA. Translation: CAH56202.1.
AL832046 mRNA. Translation: CAH56220.1.
CH471082 Genomic DNA. Translation: EAW77589.1.
BC013684 mRNA. Translation: AAH13684.1. Different initiation.
BC020918 mRNA. Translation: AAH20918.1. Sequence problems.
BC071685 mRNA. Translation: AAH71685.1.
BC107427 mRNA. Translation: AAI07428.1. Sequence problems.
BC140894 mRNA. Translation: AAI40895.1.
CCDSiCCDS10176.1. [Q659A1-1]
RefSeqiNP_001018099.1. NM_001018089.2.
NP_078887.2. NM_024611.5. [Q659A1-1]
XP_005254718.1. XM_005254661.1. [Q659A1-1]
UniGeneiHs.200943.

Genome annotation databases

EnsembliENST00000261520; ENSP00000261520; ENSG00000128915. [Q659A1-1]
ENST00000558181; ENSP00000453593; ENSG00000128915. [Q659A1-2]
ENST00000560668; ENSP00000453303; ENSG00000128915. [Q659A1-2]
GeneIDi79664.
KEGGihsa:79664.
UCSCiuc002ago.4. human. [Q659A1-1]

Polymorphism databases

DMDMi156632596.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502591 mRNA. Translation: AAQ07460.1 .
AY358546 mRNA. Translation: AAQ88910.1 . Sequence problems.
CR749852 mRNA. Translation: CAH18700.1 . Sequence problems.
BX647873 mRNA. Translation: CAH56197.1 .
AK021958 mRNA. Translation: BAB13948.1 . Different initiation.
AK055752 mRNA. Translation: BAG51567.1 .
AL833122 mRNA. Translation: CAH56202.1 .
AL832046 mRNA. Translation: CAH56220.1 .
CH471082 Genomic DNA. Translation: EAW77589.1 .
BC013684 mRNA. Translation: AAH13684.1 . Different initiation.
BC020918 mRNA. Translation: AAH20918.1 . Sequence problems.
BC071685 mRNA. Translation: AAH71685.1 .
BC107427 mRNA. Translation: AAI07428.1 . Sequence problems.
BC140894 mRNA. Translation: AAI40895.1 .
CCDSi CCDS10176.1. [Q659A1-1 ]
RefSeqi NP_001018099.1. NM_001018089.2.
NP_078887.2. NM_024611.5. [Q659A1-1 ]
XP_005254718.1. XM_005254661.1. [Q659A1-1 ]
UniGenei Hs.200943.

3D structure databases

ProteinModelPortali Q659A1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122789. 27 interactions.
IntActi Q659A1. 5 interactions.

Polymorphism databases

DMDMi 156632596.

Proteomic databases

MaxQBi Q659A1.
PaxDbi Q659A1.
PRIDEi Q659A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261520 ; ENSP00000261520 ; ENSG00000128915 . [Q659A1-1 ]
ENST00000558181 ; ENSP00000453593 ; ENSG00000128915 . [Q659A1-2 ]
ENST00000560668 ; ENSP00000453303 ; ENSG00000128915 . [Q659A1-2 ]
GeneIDi 79664.
KEGGi hsa:79664.
UCSCi uc002ago.4. human. [Q659A1-1 ]

Organism-specific databases

CTDi 79664.
GeneCardsi GC15M060711.
HGNCi HGNC:29885. ICE2.
HPAi HPA039416.
HPA040058.
MIMi 610835. gene.
neXtProti NX_Q659A1.
PharmGKBi PA134960292.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73502.
GeneTreei ENSGT00390000006883.
HOVERGENi HBG102042.
InParanoidi Q659A1.
OMAi LMGFFPF.
OrthoDBi EOG7RNJZS.
PhylomeDBi Q659A1.
TreeFami TF106272.

Miscellaneous databases

ChiTaRSi NARG2. human.
GenomeRNAii 79664.
NextBioi 68860.
PROi Q659A1.
SOURCEi Search...

Gene expression databases

Bgeei Q659A1.
ExpressionAtlasi Q659A1. baseline and differential.
Genevestigatori Q659A1.

Family and domain databases

InterProi IPR019535. NARG2_C.
[Graphical view ]
Pfami PF10505. NARG2_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcript in human breast cancer cells."
    Gokhale P.C., Dritschilo A., Rahman A., Ahmad I., Kasid U.N.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary cancer.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo and Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adipose tissue, Bone marrow, Fetal kidney and Heart.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone, Brain, Ovary and Testis.
  7. "NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development."
    Sugiura N., Dadashev V., Corriveau R.A.
    Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION IN THE LEC COMPLEX, INTERACTION WITH ELL.
  12. "The little elongation complex functions at initiation and elongation phases of snRNA gene transcription."
    Hu D., Smith E.R., Garruss A.S., Mohaghegh N., Varberg J.M., Lin C., Jackson J., Gao X., Saraf A., Florens L., Washburn M.P., Eissenberg J.C., Shilatifard A.
    Mol. Cell 51:493-505(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE LEC COMPLEX, INTERACTION WITH ICE1.

Entry informationi

Entry nameiICE2_HUMAN
AccessioniPrimary (citable) accession number: Q659A1
Secondary accession number(s): B2RU08
, Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7, Q6UX23, Q71H65, Q96CY5, Q9HAA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3