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Q659A1 (NARG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NMDA receptor-regulated protein 2
Gene names
Name:NARG2
Synonyms:BRCC1
ORF Names:UNQ3101/PRO10100
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length982 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed at low levels in lung and testis. Ref.7

Developmental stage

Expressed in fetal brain, kidney, liver and lung. Ref.7

Sequence caution

The sequence AAH13684.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH20918.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAI07428.1 differs from that shown. Reason: Probable cloning artifact.

The sequence AAQ88910.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.

The sequence BAB13948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH18700.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q659A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q659A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-73: RIGENLNASASSVENEPAVSSATQ → ESRGVMWTCWLNTQRFLQIPKLLE
     74-982: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 982982NMDA receptor-regulated protein 2
PRO_0000297964

Amino acid modifications

Modified residue5711Phosphoserine By similarity
Modified residue5731Phosphothreonine By similarity

Natural variations

Alternative sequence50 – 7324RIGEN…SSATQ → ESRGVMWTCWLNTQRFLQIP KLLE in isoform 2.
VSP_041612
Alternative sequence74 – 982909Missing in isoform 2.
VSP_041613

Experimental info

Sequence conflict2721L → P in CAH18700. Ref.4
Sequence conflict3161S → L in CAH18700. Ref.4
Sequence conflict3551T → P in CAH56220. Ref.4
Sequence conflict6211T → S in CAH56220. Ref.4
Sequence conflict7531T → A in CAH18700. Ref.4
Sequence conflict9061W → R in BAB13948. Ref.3
Sequence conflict9471P → S in CAH56197. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 09B36E742FC77597

FASTA982110,011
        10         20         30         40         50         60 
MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR IGENLNASAS 

        70         80         90        100        110        120 
SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF SQREQRSYVD LLVKYAKIPA 

       130        140        150        160        170        180 
NSKAVGINKN DYLQYLDMKK HVNEEVTEFL KFLQNSAKKC AQDYNMLSDD ARLFTEKILR 

       190        200        210        220        230        240 
ACIEQVKKYS EFYTLHEVTS LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ 

       250        260        270        280        290        300 
LSKDDIATIE TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE 

       310        320        330        340        350        360 
QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM MSKNTSVPVS 

       370        380        390        400        410        420 
AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV TELETFGVTT TKVSKSPSPA 

       430        440        450        460        470        480 
STSTVPNMTD APTAPKAGTT TVAPSAPDIS ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE 

       490        500        510        520        530        540 
CKNKDDQGFE SCEKVSNSDK PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE 

       550        560        570        580        590        600 
RPNVLENLDN SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS 

       610        620        630        640        650        660 
SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK MQDELLKPIS 

       670        680        690        700        710        720 
RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA FQKPKGRLPY ELQDYVEDTS 

       730        740        750        760        770        780 
EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR IETRPRSKKR KKIRRQFPVY VLPKVEYQAC 

       790        800        810        820        830        840 
YGVEALTESE LCRLWTESLL HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN 

       850        860        870        880        890        900 
LFNILQHILK KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS 

       910        920        930        940        950        960 
SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS HRNPVSMETK 

       970        980 
SSCLPAQQVE TEGVAPHKRK IT 

« Hide

Isoform 2 [UniParc].

Checksum: 697BA4B2564D8E2F
Show »

FASTA738,572

References

« Hide 'large scale' references
[1]"Novel transcript in human breast cancer cells."
Gokhale P.C., Dritschilo A., Rahman A., Ahmad I., Kasid U.N.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Mammary cancer.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo and Kidney.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Adipose tissue, Bone marrow, Fetal kidney and Heart.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Bone, Brain, Ovary and Testis.
[7]"NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development."
Sugiura N., Dadashev V., Corriveau R.A.
Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF502591 mRNA. Translation: AAQ07460.1.
AY358546 mRNA. Translation: AAQ88910.1. Sequence problems.
CR749852 mRNA. Translation: CAH18700.1. Sequence problems.
BX647873 mRNA. Translation: CAH56197.1.
AK021958 mRNA. Translation: BAB13948.1. Different initiation.
AK055752 mRNA. Translation: BAG51567.1.
AL833122 mRNA. Translation: CAH56202.1.
AL832046 mRNA. Translation: CAH56220.1.
CH471082 Genomic DNA. Translation: EAW77589.1.
BC013684 mRNA. Translation: AAH13684.1. Different initiation.
BC020918 mRNA. Translation: AAH20918.1. Sequence problems.
BC071685 mRNA. Translation: AAH71685.1.
BC107427 mRNA. Translation: AAI07428.1. Sequence problems.
BC140894 mRNA. Translation: AAI40895.1.
CCDSCCDS10176.1. [Q659A1-1]
RefSeqNP_001018099.1. NM_001018089.2.
NP_078887.2. NM_024611.5. [Q659A1-1]
XP_005254718.1. XM_005254661.1. [Q659A1-1]
UniGeneHs.200943.

3D structure databases

ProteinModelPortalQ659A1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122789. 8 interactions.
IntActQ659A1. 5 interactions.

Polymorphism databases

DMDM156632596.

Proteomic databases

MaxQBQ659A1.
PaxDbQ659A1.
PRIDEQ659A1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261520; ENSP00000261520; ENSG00000128915. [Q659A1-1]
ENST00000558181; ENSP00000453593; ENSG00000128915. [Q659A1-2]
ENST00000560668; ENSP00000453303; ENSG00000128915. [Q659A1-2]
GeneID79664.
KEGGhsa:79664.
UCSCuc002ago.4. human. [Q659A1-1]

Organism-specific databases

CTD79664.
GeneCardsGC15M060711.
HGNCHGNC:29885. NARG2.
HPAHPA039416.
HPA040058.
MIM610835. gene.
neXtProtNX_Q659A1.
PharmGKBPA134960292.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG73502.
HOVERGENHBG102042.
InParanoidQ659A1.
OMALMGFFPF.
OrthoDBEOG7RNJZS.
PhylomeDBQ659A1.
TreeFamTF106272.

Gene expression databases

ArrayExpressQ659A1.
BgeeQ659A1.
GenevestigatorQ659A1.

Family and domain databases

InterProIPR019535. NARG2_C.
[Graphical view]
PfamPF10505. NARG2_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNARG2. human.
GenomeRNAi79664.
NextBio68860.
PROQ659A1.
SOURCESearch...

Entry information

Entry nameNARG2_HUMAN
AccessionPrimary (citable) accession number: Q659A1
Secondary accession number(s): B2RU08 expand/collapse secondary AC list , Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7, Q6UX23, Q71H65, Q96CY5, Q9HAA2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM