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Q659A1

- ICE2_HUMAN

UniProt

Q659A1 - ICE2_HUMAN

Protein

Little elongation complex subunit 2

Gene

ICE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.1 Publication

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Little elongation complex subunit 2
    Alternative name(s):
    Interactor of little elongator complex ELL subunit 2
    NMDA receptor-regulated protein 2
    Gene namesi
    Name:ICE2
    Synonyms:BRCC1, NARG2
    ORF Names:UNQ3101/PRO10100
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29885. ICE2.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960292.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 982982Little elongation complex subunit 2PRO_0000297964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei571 – 5711PhosphoserineBy similarity
    Modified residuei573 – 5731PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ659A1.
    PaxDbiQ659A1.
    PRIDEiQ659A1.

    Expressioni

    Tissue specificityi

    Expressed at low levels in lung and testis.1 Publication

    Developmental stagei

    Expressed in fetal brain, kidney, liver and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ659A1.
    BgeeiQ659A1.
    GenevestigatoriQ659A1.

    Organism-specific databases

    HPAiHPA039416.
    HPA040058.

    Interactioni

    Subunit structurei

    Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.2 Publications

    Protein-protein interaction databases

    BioGridi122789. 8 interactions.
    IntActiQ659A1. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ659A1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ICE2 family.Curated

    Phylogenomic databases

    eggNOGiNOG73502.
    HOVERGENiHBG102042.
    InParanoidiQ659A1.
    OMAiLMGFFPF.
    OrthoDBiEOG7RNJZS.
    PhylomeDBiQ659A1.
    TreeFamiTF106272.

    Family and domain databases

    InterProiIPR019535. NARG2_C.
    [Graphical view]
    PfamiPF10505. NARG2_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q659A1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR    50
    IGENLNASAS SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF 100
    SQREQRSYVD LLVKYAKIPA NSKAVGINKN DYLQYLDMKK HVNEEVTEFL 150
    KFLQNSAKKC AQDYNMLSDD ARLFTEKILR ACIEQVKKYS EFYTLHEVTS 200
    LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ LSKDDIATIE 250
    TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE 300
    QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM 350
    MSKNTSVPVS AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV 400
    TELETFGVTT TKVSKSPSPA STSTVPNMTD APTAPKAGTT TVAPSAPDIS 450
    ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE CKNKDDQGFE SCEKVSNSDK 500
    PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE RPNVLENLDN 550
    SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS 600
    SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK 650
    MQDELLKPIS RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA 700
    FQKPKGRLPY ELQDYVEDTS EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR 750
    IETRPRSKKR KKIRRQFPVY VLPKVEYQAC YGVEALTESE LCRLWTESLL 800
    HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN LFNILQHILK 850
    KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS 900
    SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS 950
    HRNPVSMETK SSCLPAQQVE TEGVAPHKRK IT 982
    Length:982
    Mass (Da):110,011
    Last modified:August 21, 2007 - v2
    Checksum:i09B36E742FC77597
    GO
    Isoform 2 (identifier: Q659A1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-73: RIGENLNASASSVENEPAVSSATQ → ESRGVMWTCWLNTQRFLQIPKLLE
         74-982: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:73
    Mass (Da):8,572
    Checksum:i697BA4B2564D8E2F
    GO

    Sequence cautioni

    The sequence AAH20918.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAI07428.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence AAQ88910.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
    The sequence AAH13684.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB13948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721L → P in CAH18700. (PubMed:17974005)Curated
    Sequence conflicti316 – 3161S → L in CAH18700. (PubMed:17974005)Curated
    Sequence conflicti355 – 3551T → P in CAH56220. (PubMed:17974005)Curated
    Sequence conflicti621 – 6211T → S in CAH56220. (PubMed:17974005)Curated
    Sequence conflicti753 – 7531T → A in CAH18700. (PubMed:17974005)Curated
    Sequence conflicti906 – 9061W → R in BAB13948. (PubMed:14702039)Curated
    Sequence conflicti947 – 9471P → S in CAH56197. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei50 – 7324RIGEN…SSATQ → ESRGVMWTCWLNTQRFLQIP KLLE in isoform 2. 1 PublicationVSP_041612Add
    BLAST
    Alternative sequencei74 – 982909Missing in isoform 2. 1 PublicationVSP_041613Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502591 mRNA. Translation: AAQ07460.1.
    AY358546 mRNA. Translation: AAQ88910.1. Sequence problems.
    CR749852 mRNA. Translation: CAH18700.1. Sequence problems.
    BX647873 mRNA. Translation: CAH56197.1.
    AK021958 mRNA. Translation: BAB13948.1. Different initiation.
    AK055752 mRNA. Translation: BAG51567.1.
    AL833122 mRNA. Translation: CAH56202.1.
    AL832046 mRNA. Translation: CAH56220.1.
    CH471082 Genomic DNA. Translation: EAW77589.1.
    BC013684 mRNA. Translation: AAH13684.1. Different initiation.
    BC020918 mRNA. Translation: AAH20918.1. Sequence problems.
    BC071685 mRNA. Translation: AAH71685.1.
    BC107427 mRNA. Translation: AAI07428.1. Sequence problems.
    BC140894 mRNA. Translation: AAI40895.1.
    CCDSiCCDS10176.1. [Q659A1-1]
    RefSeqiNP_001018099.1. NM_001018089.2.
    NP_078887.2. NM_024611.5. [Q659A1-1]
    XP_005254718.1. XM_005254661.1. [Q659A1-1]
    UniGeneiHs.200943.

    Genome annotation databases

    EnsembliENST00000261520; ENSP00000261520; ENSG00000128915. [Q659A1-1]
    ENST00000558181; ENSP00000453593; ENSG00000128915. [Q659A1-2]
    ENST00000560668; ENSP00000453303; ENSG00000128915. [Q659A1-2]
    GeneIDi79664.
    KEGGihsa:79664.
    UCSCiuc002ago.4. human. [Q659A1-1]

    Polymorphism databases

    DMDMi156632596.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502591 mRNA. Translation: AAQ07460.1 .
    AY358546 mRNA. Translation: AAQ88910.1 . Sequence problems.
    CR749852 mRNA. Translation: CAH18700.1 . Sequence problems.
    BX647873 mRNA. Translation: CAH56197.1 .
    AK021958 mRNA. Translation: BAB13948.1 . Different initiation.
    AK055752 mRNA. Translation: BAG51567.1 .
    AL833122 mRNA. Translation: CAH56202.1 .
    AL832046 mRNA. Translation: CAH56220.1 .
    CH471082 Genomic DNA. Translation: EAW77589.1 .
    BC013684 mRNA. Translation: AAH13684.1 . Different initiation.
    BC020918 mRNA. Translation: AAH20918.1 . Sequence problems.
    BC071685 mRNA. Translation: AAH71685.1 .
    BC107427 mRNA. Translation: AAI07428.1 . Sequence problems.
    BC140894 mRNA. Translation: AAI40895.1 .
    CCDSi CCDS10176.1. [Q659A1-1 ]
    RefSeqi NP_001018099.1. NM_001018089.2.
    NP_078887.2. NM_024611.5. [Q659A1-1 ]
    XP_005254718.1. XM_005254661.1. [Q659A1-1 ]
    UniGenei Hs.200943.

    3D structure databases

    ProteinModelPortali Q659A1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122789. 8 interactions.
    IntActi Q659A1. 5 interactions.

    Polymorphism databases

    DMDMi 156632596.

    Proteomic databases

    MaxQBi Q659A1.
    PaxDbi Q659A1.
    PRIDEi Q659A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261520 ; ENSP00000261520 ; ENSG00000128915 . [Q659A1-1 ]
    ENST00000558181 ; ENSP00000453593 ; ENSG00000128915 . [Q659A1-2 ]
    ENST00000560668 ; ENSP00000453303 ; ENSG00000128915 . [Q659A1-2 ]
    GeneIDi 79664.
    KEGGi hsa:79664.
    UCSCi uc002ago.4. human. [Q659A1-1 ]

    Organism-specific databases

    CTDi 79664.
    GeneCardsi GC15M060711.
    HGNCi HGNC:29885. ICE2.
    HPAi HPA039416.
    HPA040058.
    MIMi 610835. gene.
    neXtProti NX_Q659A1.
    PharmGKBi PA134960292.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73502.
    HOVERGENi HBG102042.
    InParanoidi Q659A1.
    OMAi LMGFFPF.
    OrthoDBi EOG7RNJZS.
    PhylomeDBi Q659A1.
    TreeFami TF106272.

    Miscellaneous databases

    ChiTaRSi NARG2. human.
    GenomeRNAii 79664.
    NextBioi 68860.
    PROi Q659A1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q659A1.
    Bgeei Q659A1.
    Genevestigatori Q659A1.

    Family and domain databases

    InterProi IPR019535. NARG2_C.
    [Graphical view ]
    Pfami PF10505. NARG2_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel transcript in human breast cancer cells."
      Gokhale P.C., Dritschilo A., Rahman A., Ahmad I., Kasid U.N.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary cancer.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo and Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adipose tissue, Bone marrow, Fetal kidney and Heart.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone, Brain, Ovary and Testis.
    7. "NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development."
      Sugiura N., Dadashev V., Corriveau R.A.
      Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION IN THE LEC COMPLEX, INTERACTION WITH ELL.
    12. "The little elongation complex functions at initiation and elongation phases of snRNA gene transcription."
      Hu D., Smith E.R., Garruss A.S., Mohaghegh N., Varberg J.M., Lin C., Jackson J., Gao X., Saraf A., Florens L., Washburn M.P., Eissenberg J.C., Shilatifard A.
      Mol. Cell 51:493-505(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE LEC COMPLEX, INTERACTION WITH ICE1.

    Entry informationi

    Entry nameiICE2_HUMAN
    AccessioniPrimary (citable) accession number: Q659A1
    Secondary accession number(s): B2RU08
    , Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7, Q6UX23, Q71H65, Q96CY5, Q9HAA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3