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Q659A1

- NARG2_HUMAN

UniProt

Q659A1 - NARG2_HUMAN

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Protein
NMDA receptor-regulated protein 2
Gene
NARG2, BRCC1, UNQ3101/PRO10100
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NMDA receptor-regulated protein 2
Gene namesi
Name:NARG2
Synonyms:BRCC1
ORF Names:UNQ3101/PRO10100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:29885. NARG2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982NMDA receptor-regulated protein 2
PRO_0000297964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei571 – 5711Phosphoserine By similarity
Modified residuei573 – 5731Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ659A1.
PaxDbiQ659A1.
PRIDEiQ659A1.

Expressioni

Tissue specificityi

Expressed at low levels in lung and testis.1 Publication

Developmental stagei

Expressed in fetal brain, kidney, liver and lung.1 Publication

Gene expression databases

ArrayExpressiQ659A1.
BgeeiQ659A1.
GenevestigatoriQ659A1.

Organism-specific databases

HPAiHPA039416.
HPA040058.

Interactioni

Protein-protein interaction databases

BioGridi122789. 8 interactions.
IntActiQ659A1. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ659A1.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG73502.
HOVERGENiHBG102042.
InParanoidiQ659A1.
OMAiLMGFFPF.
OrthoDBiEOG7RNJZS.
PhylomeDBiQ659A1.
TreeFamiTF106272.

Family and domain databases

InterProiIPR019535. NARG2_C.
[Graphical view]
PfamiPF10505. NARG2_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q659A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR    50
IGENLNASAS SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF 100
SQREQRSYVD LLVKYAKIPA NSKAVGINKN DYLQYLDMKK HVNEEVTEFL 150
KFLQNSAKKC AQDYNMLSDD ARLFTEKILR ACIEQVKKYS EFYTLHEVTS 200
LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ LSKDDIATIE 250
TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE 300
QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM 350
MSKNTSVPVS AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV 400
TELETFGVTT TKVSKSPSPA STSTVPNMTD APTAPKAGTT TVAPSAPDIS 450
ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE CKNKDDQGFE SCEKVSNSDK 500
PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE RPNVLENLDN 550
SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS 600
SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK 650
MQDELLKPIS RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA 700
FQKPKGRLPY ELQDYVEDTS EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR 750
IETRPRSKKR KKIRRQFPVY VLPKVEYQAC YGVEALTESE LCRLWTESLL 800
HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN LFNILQHILK 850
KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS 900
SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS 950
HRNPVSMETK SSCLPAQQVE TEGVAPHKRK IT 982
Length:982
Mass (Da):110,011
Last modified:August 21, 2007 - v2
Checksum:i09B36E742FC77597
GO
Isoform 2 (identifier: Q659A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-73: RIGENLNASASSVENEPAVSSATQ → ESRGVMWTCWLNTQRFLQIPKLLE
     74-982: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:73
Mass (Da):8,572
Checksum:i697BA4B2564D8E2F
GO

Sequence cautioni

The sequence AAH20918.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI07428.1 differs from that shown. Reason: Probable cloning artifact.
The sequence AAQ88910.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
The sequence AAH13684.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB13948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 7324RIGEN…SSATQ → ESRGVMWTCWLNTQRFLQIP KLLE in isoform 2.
VSP_041612Add
BLAST
Alternative sequencei74 – 982909Missing in isoform 2.
VSP_041613Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721L → P in CAH18700. 1 Publication
Sequence conflicti316 – 3161S → L in CAH18700. 1 Publication
Sequence conflicti355 – 3551T → P in CAH56220. 1 Publication
Sequence conflicti621 – 6211T → S in CAH56220. 1 Publication
Sequence conflicti753 – 7531T → A in CAH18700. 1 Publication
Sequence conflicti906 – 9061W → R in BAB13948. 1 Publication
Sequence conflicti947 – 9471P → S in CAH56197. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502591 mRNA. Translation: AAQ07460.1.
AY358546 mRNA. Translation: AAQ88910.1. Sequence problems.
CR749852 mRNA. Translation: CAH18700.1. Sequence problems.
BX647873 mRNA. Translation: CAH56197.1.
AK021958 mRNA. Translation: BAB13948.1. Different initiation.
AK055752 mRNA. Translation: BAG51567.1.
AL833122 mRNA. Translation: CAH56202.1.
AL832046 mRNA. Translation: CAH56220.1.
CH471082 Genomic DNA. Translation: EAW77589.1.
BC013684 mRNA. Translation: AAH13684.1. Different initiation.
BC020918 mRNA. Translation: AAH20918.1. Sequence problems.
BC071685 mRNA. Translation: AAH71685.1.
BC107427 mRNA. Translation: AAI07428.1. Sequence problems.
BC140894 mRNA. Translation: AAI40895.1.
CCDSiCCDS10176.1. [Q659A1-1]
RefSeqiNP_001018099.1. NM_001018089.2.
NP_078887.2. NM_024611.5. [Q659A1-1]
XP_005254718.1. XM_005254661.1. [Q659A1-1]
UniGeneiHs.200943.

Genome annotation databases

EnsembliENST00000261520; ENSP00000261520; ENSG00000128915. [Q659A1-1]
ENST00000558181; ENSP00000453593; ENSG00000128915. [Q659A1-2]
ENST00000560668; ENSP00000453303; ENSG00000128915. [Q659A1-2]
GeneIDi79664.
KEGGihsa:79664.
UCSCiuc002ago.4. human. [Q659A1-1]

Polymorphism databases

DMDMi156632596.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502591 mRNA. Translation: AAQ07460.1 .
AY358546 mRNA. Translation: AAQ88910.1 . Sequence problems.
CR749852 mRNA. Translation: CAH18700.1 . Sequence problems.
BX647873 mRNA. Translation: CAH56197.1 .
AK021958 mRNA. Translation: BAB13948.1 . Different initiation.
AK055752 mRNA. Translation: BAG51567.1 .
AL833122 mRNA. Translation: CAH56202.1 .
AL832046 mRNA. Translation: CAH56220.1 .
CH471082 Genomic DNA. Translation: EAW77589.1 .
BC013684 mRNA. Translation: AAH13684.1 . Different initiation.
BC020918 mRNA. Translation: AAH20918.1 . Sequence problems.
BC071685 mRNA. Translation: AAH71685.1 .
BC107427 mRNA. Translation: AAI07428.1 . Sequence problems.
BC140894 mRNA. Translation: AAI40895.1 .
CCDSi CCDS10176.1. [Q659A1-1 ]
RefSeqi NP_001018099.1. NM_001018089.2.
NP_078887.2. NM_024611.5. [Q659A1-1 ]
XP_005254718.1. XM_005254661.1. [Q659A1-1 ]
UniGenei Hs.200943.

3D structure databases

ProteinModelPortali Q659A1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122789. 8 interactions.
IntActi Q659A1. 5 interactions.

Polymorphism databases

DMDMi 156632596.

Proteomic databases

MaxQBi Q659A1.
PaxDbi Q659A1.
PRIDEi Q659A1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261520 ; ENSP00000261520 ; ENSG00000128915 . [Q659A1-1 ]
ENST00000558181 ; ENSP00000453593 ; ENSG00000128915 . [Q659A1-2 ]
ENST00000560668 ; ENSP00000453303 ; ENSG00000128915 . [Q659A1-2 ]
GeneIDi 79664.
KEGGi hsa:79664.
UCSCi uc002ago.4. human. [Q659A1-1 ]

Organism-specific databases

CTDi 79664.
GeneCardsi GC15M060711.
HGNCi HGNC:29885. NARG2.
HPAi HPA039416.
HPA040058.
MIMi 610835. gene.
neXtProti NX_Q659A1.
PharmGKBi PA134960292.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73502.
HOVERGENi HBG102042.
InParanoidi Q659A1.
OMAi LMGFFPF.
OrthoDBi EOG7RNJZS.
PhylomeDBi Q659A1.
TreeFami TF106272.

Miscellaneous databases

ChiTaRSi NARG2. human.
GenomeRNAii 79664.
NextBioi 68860.
PROi Q659A1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q659A1.
Bgeei Q659A1.
Genevestigatori Q659A1.

Family and domain databases

InterProi IPR019535. NARG2_C.
[Graphical view ]
Pfami PF10505. NARG2_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcript in human breast cancer cells."
    Gokhale P.C., Dritschilo A., Rahman A., Ahmad I., Kasid U.N.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Mammary cancer.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo and Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adipose tissue, Bone marrow, Fetal kidney and Heart.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone, Brain, Ovary and Testis.
  7. "NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development."
    Sugiura N., Dadashev V., Corriveau R.A.
    Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNARG2_HUMAN
AccessioniPrimary (citable) accession number: Q659A1
Secondary accession number(s): B2RU08
, Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7, Q6UX23, Q71H65, Q96CY5, Q9HAA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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