Q659A1 (NARG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NMDA receptor-regulated protein 2

Gene names

Name:	NARG2
Synonyms:	BRCC1
ORF Names:	UNQ3101/PRO10100

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	982 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed at low levels in lung and testis. Ref.7
Developmental stage	Expressed in fetal brain, kidney, liver and lung. Ref.7
Sequence caution	The sequence AAH13684.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH20918.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAI07428.1 differs from that shown. Reason: Probable cloning artifact. The sequence AAQ88910.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites. The sequence BAB13948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH18700.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q659A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q659A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-73: RIGENLNASASSVENEPAVSSATQ → ESRGVMWTCWLNTQRFLQIPKLLE
     74-982: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 982	982	NMDA receptor-regulated protein 2		PRO_0000297964
Amino acid modifications
	Modified residue	571	1	Phosphoserine By similarity
	Modified residue	573	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	50 – 73	24	RIGEN…SSATQ → ESRGVMWTCWLNTQRFLQIP KLLE in isoform 2.		VSP_041612
	Alternative sequence	74 – 982	909	Missing in isoform 2.		VSP_041613
Experimental info
	Sequence conflict	272	1	L → P in CAH18700. Ref.4
	Sequence conflict	316	1	S → L in CAH18700. Ref.4
	Sequence conflict	355	1	T → P in CAH56220. Ref.4
	Sequence conflict	621	1	T → S in CAH56220. Ref.4
	Sequence conflict	753	1	T → A in CAH18700. Ref.4
	Sequence conflict	906	1	W → R in BAB13948. Ref.3
	Sequence conflict	947	1	P → S in CAH56197. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 09B36E742FC77597	FASTA	982	110,011
	10 20 30 40 50 60 MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR IGENLNASAS 70 80 90 100 110 120 SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF SQREQRSYVD LLVKYAKIPA 130 140 150 160 170 180 NSKAVGINKN DYLQYLDMKK HVNEEVTEFL KFLQNSAKKC AQDYNMLSDD ARLFTEKILR 190 200 210 220 230 240 ACIEQVKKYS EFYTLHEVTS LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ 250 260 270 280 290 300 LSKDDIATIE TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE 310 320 330 340 350 360 QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM MSKNTSVPVS 370 380 390 400 410 420 AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV TELETFGVTT TKVSKSPSPA 430 440 450 460 470 480 STSTVPNMTD APTAPKAGTT TVAPSAPDIS ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE 490 500 510 520 530 540 CKNKDDQGFE SCEKVSNSDK PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE 550 560 570 580 590 600 RPNVLENLDN SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS 610 620 630 640 650 660 SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK MQDELLKPIS 670 680 690 700 710 720 RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA FQKPKGRLPY ELQDYVEDTS 730 740 750 760 770 780 EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR IETRPRSKKR KKIRRQFPVY VLPKVEYQAC 790 800 810 820 830 840 YGVEALTESE LCRLWTESLL HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN 850 860 870 880 890 900 LFNILQHILK KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS 910 920 930 940 950 960 SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS HRNPVSMETK 970 980 SSCLPAQQVE TEGVAPHKRK IT
	Isoform 2 [UniParc]. Checksum: 697BA4B2564D8E2F	FASTA	73	8,572
	10 20 30 40 50 60 MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRE SRGVMWTCWL 70 NTQRFLQIPK LLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel transcript in human breast cancer cells." Gokhale P.C., Dritschilo A., Rahman A., Ahmad I., Kasid U.N. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary cancer.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo and Kidney.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adipose tissue, Bone marrow, Fetal kidney and Heart.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone, Brain, Ovary and Testis.
[7]	"NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development." Sugiura N., Dadashev V., Corriveau R.A. Eur. J. Biochem. 271:4629-4637(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF502591 mRNA. Translation: AAQ07460.1. AY358546 mRNA. Translation: AAQ88910.1. Sequence problems. CR749852 mRNA. Translation: CAH18700.1. Sequence problems. BX647873 mRNA. Translation: CAH56197.1. AK021958 mRNA. Translation: BAB13948.1. Different initiation. AK055752 mRNA. Translation: BAG51567.1. AL833122 mRNA. Translation: CAH56202.1. AL832046 mRNA. Translation: CAH56220.1. CH471082 Genomic DNA. Translation: EAW77589.1. BC013684 mRNA. Translation: AAH13684.1. Different initiation. BC020918 mRNA. Translation: AAH20918.1. Sequence problems. BC071685 mRNA. Translation: AAH71685.1. BC107427 mRNA. Translation: AAI07428.1. Sequence problems. BC140894 mRNA. Translation: AAI40895.1.
IPI	IPI00470407. IPI00604683.
RefSeq	NP_078887.2. NM_024611.5.
UniGene	Hs.200943.
3D structure databases
ProteinModelPortal	Q659A1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q659A1. 4 interactions.
Polymorphism databases
DMDM	156632596.
Proteomic databases
PaxDb	Q659A1.
PRIDE	Q659A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261520; ENSP00000261520; ENSG00000128915. ENST00000558181; ENSP00000453593; ENSG00000128915. ENST00000560668; ENSP00000453303; ENSG00000128915.
GeneID	79664.
KEGG	hsa:79664.
UCSC	uc002ago.3. human.
Organism-specific databases
CTD	79664.
GeneCards	GC15M060711.
HGNC	HGNC:29885. NARG2.
HPA	HPA039416. HPA040058.
MIM	610835. gene.
neXtProt	NX_Q659A1.
PharmGKB	PA134960292.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73502.
HOVERGEN	HBG102042.
InParanoid	Q659A1.
OMA	VPWVPLD.
OrthoDB	EOG4FJ88M.
PhylomeDB	Q659A1.
Gene expression databases
ArrayExpress	Q659A1.
Bgee	Q659A1.
Genevestigator	Q659A1.
Family and domain databases
InterPro	IPR019535. NARG2_C. [Graphical view]
Pfam	PF10505. NARG2_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NARG2. human.
GenomeRNAi	79664.
NextBio	68860.
SOURCE	Search...

Entry information

Entry name

NARG2_HUMAN

Accession

Primary (citable) accession number: Q659A1
Secondary accession number(s): B2RU08 , Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7, Q6UX23, Q71H65, Q96CY5, Q9HAA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	April 3, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.