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Protein

Core-capsid bridging protein

Gene

L2

Organism
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear capsid assembly of the viral particles through its association with NPM1/nucleophosmin.UniRule annotation

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.UniRule annotation
This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processViral capsid assembly, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Core-capsid bridging proteinUniRule annotation
Alternative name(s):
Core protein VUniRule annotation
Gene namesi
Name:L2UniRule annotation
OrganismiCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Taxonomic identifieri69150 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusCanine mastadenovirus A
Virus hostiCanis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleushost nucleolus UniRule annotation

  • Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002219081 – 421Core-capsid bridging proteinAdd BLAST421

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.UniRule annotation

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Monomer. Homodimer. Exists in equilibrium between monomers and dimers in solution. Interacts with the histone-like nucleoprotein; this interactions bridge the virus core to the capsid. Interacts with core protein X; this interactions bridge the virus core to the capsid. Interacts with the endosome lysis protein VI; this interactions bridge the virus core to the capsid. Interacts with the peripentonal hexons. Interacts with host NPM1; this interaction might play a role in virus assembly.UniRule annotation

Structurei

3D structure databases

SMRiQ65952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenoviridae core-capsid bridging protein family.UniRule annotationCurated

Family and domain databases

HAMAPiMF_04053. ADV_CORE5. 1 hit.
InterProiView protein in InterPro
IPR005608. Adeno_PV.
PfamiView protein in Pfam
PF03910. Adeno_PV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAISRAIKQ ELLEDLKPEM YLPPKSTRRR AKVKTEEKVD VKTLVKSKSK
60 70 80 90 100
KRRAAKNELE ENVEFVRRFA PRRPYQWRGR QVRALPRPGI PVVFTPGQRS
110 120 130 140 150
GVASKRSYDE VYADEDVLDQ SGNMINEFAY GKRVKMLTHK NPTPSQVPIT
160 170 180 190 200
PQEPIARPGE AGLLPTVQVL APRDSKHETM LPVTKSEGGD VKVENKGFEQ
210 220 230 240 250
ITPQLGVQTV DIKVPVKRKS EVEDEILKRA KMEPFETTVK MEYSEQPQVE
260 270 280 290 300
VFDTGVEPSS FFEVRSQARP IAVARKRRVP TVEVMEVQQS DHTAPTASAA
310 320 330 340 350
PVANVIVGPH LSRRPSRWGP ANAIYPDYVY HPSISAKKTM GPRPTGRVSR
360 370 380 390 400
WGPANSIFPE VRLHPSMVSA VTRAAPRKST KSRRRRRVRT RRAFVLPAGT
410 420
KTGVMLPQNI RYHPSILFRR A
Length:421
Mass (Da):47,538
Last modified:November 1, 1997 - v1
Checksum:iC84536291CDDEEF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55001 Genomic DNA. Translation: AAB05440.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCORE5_ADECC
AccessioniPrimary (citable) accession number: Q65952
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families