Q65952 (CORE5_ADECC) Reviewed, UniProtKB/Swiss-Prot
Last modified May 1, 2013. Version 30. History...
Names and origin
|Protein names||Recommended name:|
Core-capsid bridging protein
Core protein V
|Organism||Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))|
|Taxonomic identifier||69150 [NCBI]|
|Taxonomic lineage||Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Canine adenovirus A ›|
|Virus host||Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]|
|Sequence length||421 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear assembly of the viral particles through its association with NPM1/nucleophosmin By similarity.
Interacts with the histone-like nucleoprotein, core protein X and the endosome lysis protein; these interactions bridge the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in virus assembly By similarity.
Virion By similarity. Host nucleus › host nucleolus By similarity. Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles By similarity.
Expressed in the late phase of the viral replicative cycle.
This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.
Belongs to the adenoviridae core-capsid bridging protein family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 421||421||Core-capsid bridging protein||PRO_0000221908|
|U55001 Genomic DNA. Translation: AAB05440.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR005608. Adeno_PV. |
|Pfam||PF03910. Adeno_PV. 1 hit. |
|Accession||Primary (citable) accession number: Q65952|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families