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Q65952

- CORE5_ADECC

UniProt

Q65952 - CORE5_ADECC

Protein

Core-capsid bridging protein

Gene

L2

Organism
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear assembly of the viral particles through its association with NPM1/nucleophosmin By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Core-capsid bridging protein
    Alternative name(s):
    Core protein V
    Gene namesi
    ORF Names:L2
    OrganismiCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
    Taxonomic identifieri69150 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusCanine mastadenovirus A
    Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

    Subcellular locationi

    Virion By similarity. Host nucleushost nucleolus By similarity
    Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles By similarity.By similarity

    GO - Cellular componenti

    1. host cell nucleolus Source: UniProtKB-SubCell
    2. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Core-capsid bridging proteinPRO_0000221908Add
    BLAST

    Expressioni

    Inductioni

    Expressed in the late phase of the viral replicative cycle.

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Interacts with the histone-like nucleoprotein, core protein X and the endosome lysis protein; these interactions bridge the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in virus assembly By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR005608. Adeno_PV.
    [Graphical view]
    PfamiPF03910. Adeno_PV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65952-1 [UniParc]FASTAAdd to Basket

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    MAAISRAIKQ ELLEDLKPEM YLPPKSTRRR AKVKTEEKVD VKTLVKSKSK    50
    KRRAAKNELE ENVEFVRRFA PRRPYQWRGR QVRALPRPGI PVVFTPGQRS 100
    GVASKRSYDE VYADEDVLDQ SGNMINEFAY GKRVKMLTHK NPTPSQVPIT 150
    PQEPIARPGE AGLLPTVQVL APRDSKHETM LPVTKSEGGD VKVENKGFEQ 200
    ITPQLGVQTV DIKVPVKRKS EVEDEILKRA KMEPFETTVK MEYSEQPQVE 250
    VFDTGVEPSS FFEVRSQARP IAVARKRRVP TVEVMEVQQS DHTAPTASAA 300
    PVANVIVGPH LSRRPSRWGP ANAIYPDYVY HPSISAKKTM GPRPTGRVSR 350
    WGPANSIFPE VRLHPSMVSA VTRAAPRKST KSRRRRRVRT RRAFVLPAGT 400
    KTGVMLPQNI RYHPSILFRR A 421
    Length:421
    Mass (Da):47,538
    Last modified:November 1, 1997 - v1
    Checksum:iC84536291CDDEEF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55001 Genomic DNA. Translation: AAB05440.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55001 Genomic DNA. Translation: AAB05440.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005608. Adeno_PV.
    [Graphical view ]
    Pfami PF03910. Adeno_PV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and genomic organization of canine adenovirus type 1."
      Campbell J.B., Zhao Y.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCORE5_ADECC
    AccessioniPrimary (citable) accession number: Q65952
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
    All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3