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Q65952

- CORE5_ADECC

UniProt

Q65952 - CORE5_ADECC

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Protein
Core-capsid bridging protein
Gene
L2
Organism
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear assembly of the viral particles through its association with NPM1/nucleophosmin By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Core-capsid bridging protein
Alternative name(s):
Core protein V
Gene namesi
ORF Names:L2
OrganismiCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Taxonomic identifieri69150 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusCanine adenovirus A
Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

Subcellular locationi

Virion By similarity. Host nucleushost nucleolus By similarity
Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles By similarity.

GO - Cellular componenti

  1. host cell nucleolus Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Core-capsid bridging protein
PRO_0000221908Add
BLAST

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with the histone-like nucleoprotein, core protein X and the endosome lysis protein; these interactions bridge the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in virus assembly By similarity.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005608. Adeno_PV.
[Graphical view]
PfamiPF03910. Adeno_PV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65952-1 [UniParc]FASTAAdd to Basket

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MAAISRAIKQ ELLEDLKPEM YLPPKSTRRR AKVKTEEKVD VKTLVKSKSK    50
KRRAAKNELE ENVEFVRRFA PRRPYQWRGR QVRALPRPGI PVVFTPGQRS 100
GVASKRSYDE VYADEDVLDQ SGNMINEFAY GKRVKMLTHK NPTPSQVPIT 150
PQEPIARPGE AGLLPTVQVL APRDSKHETM LPVTKSEGGD VKVENKGFEQ 200
ITPQLGVQTV DIKVPVKRKS EVEDEILKRA KMEPFETTVK MEYSEQPQVE 250
VFDTGVEPSS FFEVRSQARP IAVARKRRVP TVEVMEVQQS DHTAPTASAA 300
PVANVIVGPH LSRRPSRWGP ANAIYPDYVY HPSISAKKTM GPRPTGRVSR 350
WGPANSIFPE VRLHPSMVSA VTRAAPRKST KSRRRRRVRT RRAFVLPAGT 400
KTGVMLPQNI RYHPSILFRR A 421
Length:421
Mass (Da):47,538
Last modified:November 1, 1997 - v1
Checksum:iC84536291CDDEEF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55001 Genomic DNA. Translation: AAB05440.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55001 Genomic DNA. Translation: AAB05440.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005608. Adeno_PV.
[Graphical view ]
Pfami PF03910. Adeno_PV. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and genomic organization of canine adenovirus type 1."
    Campbell J.B., Zhao Y.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCORE5_ADECC
AccessioniPrimary (citable) accession number: Q65952
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 29, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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