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Q65952 (CORE5_ADECC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Core-capsid bridging protein
Alternative name(s):
Core protein V
Gene names
ORF Names:L2
OrganismCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
Taxonomic identifier69150 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusCanine adenovirus A
Virus hostCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear assembly of the viral particles through its association with NPM1/nucleophosmin By similarity.

Subunit structure

Interacts with the histone-like nucleoprotein, core protein X and the endosome lysis protein; these interactions bridge the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in virus assembly By similarity.

Subcellular location

Virion By similarity. Host nucleushost nucleolus By similarity. Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles By similarity.

Induction

Expressed in the late phase of the viral replicative cycle.

Miscellaneous

This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism.

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.

Sequence similarities

Belongs to the adenoviridae core-capsid bridging protein family.

Ontologies

Keywords
   Cellular componentHost nucleus
Virion
   Developmental stageLate protein
Gene Ontology (GO)
   Cellular_componenthost cell nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

virion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Core-capsid bridging protein
PRO_0000221908

Sequences

Sequence LengthMass (Da)Tools
Q65952 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C84536291CDDEEF9

FASTA42147,538
        10         20         30         40         50         60 
MAAISRAIKQ ELLEDLKPEM YLPPKSTRRR AKVKTEEKVD VKTLVKSKSK KRRAAKNELE 

        70         80         90        100        110        120 
ENVEFVRRFA PRRPYQWRGR QVRALPRPGI PVVFTPGQRS GVASKRSYDE VYADEDVLDQ 

       130        140        150        160        170        180 
SGNMINEFAY GKRVKMLTHK NPTPSQVPIT PQEPIARPGE AGLLPTVQVL APRDSKHETM 

       190        200        210        220        230        240 
LPVTKSEGGD VKVENKGFEQ ITPQLGVQTV DIKVPVKRKS EVEDEILKRA KMEPFETTVK 

       250        260        270        280        290        300 
MEYSEQPQVE VFDTGVEPSS FFEVRSQARP IAVARKRRVP TVEVMEVQQS DHTAPTASAA 

       310        320        330        340        350        360 
PVANVIVGPH LSRRPSRWGP ANAIYPDYVY HPSISAKKTM GPRPTGRVSR WGPANSIFPE 

       370        380        390        400        410        420 
VRLHPSMVSA VTRAAPRKST KSRRRRRVRT RRAFVLPAGT KTGVMLPQNI RYHPSILFRR 


A 

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References

[1]"DNA sequence and genomic organization of canine adenovirus type 1."
Campbell J.B., Zhao Y.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55001 Genomic DNA. Translation: AAB05440.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005608. Adeno_PV.
[Graphical view]
PfamPF03910. Adeno_PV. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCORE5_ADECC
AccessionPrimary (citable) accession number: Q65952
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 29, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families