Q65952 (CORE5_ADECC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Core-capsid bridging protein

Alternative name(s):
Core protein V

Gene names

ORF Names:

L2

Organism

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Taxonomic identifier

69150 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Canine adenovirus A › Canine adenovirus 1

Virus host

Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Associates loosely with the viral DNA to form an outer shell around the nucleoprotein-DNA complex and links it with the capsid by binding the endosome lysis protein. Dissociates from the viral genome during entry. Might be involved in nuclear assembly of the viral particles through its association with NPM1/nucleophosmin By similarity.
Subunit structure	Interacts with the histone-like nucleoprotein, core protein X and the endosome lysis protein; these interactions bridge the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in virus assembly By similarity.
Subcellular location	Virion By similarity. Host nucleus › host nucleolus By similarity. Note: Located inside the capsid (core). Present in 157 copies per virion. Localizes in the nucleoli during infection, then translocates from the nucleoli to the nucleoplasm as the infection progresses and is finally incorporated into the viral particles By similarity.
Induction	Expressed in the late phase of the viral replicative cycle.
Miscellaneous	This protein is only encoded by mastadenoviruses, and may therefore play a role in mammals tropism. All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.
Sequence similarities	Belongs to the adenoviridae core-capsid bridging protein family.

Ontologies

Keywords
Cellular component	Host nucleus Virion
Developmental stage	Late protein
Gene Ontology (GO)
Cellular_component	host cell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell virion part Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Core-capsid bridging protein		PRO_0000221908

Sequences

	Sequence		Length	Mass (Da)
	Q65952 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C84536291CDDEEF9	FASTA	421	47,538
	10 20 30 40 50 60 MAAISRAIKQ ELLEDLKPEM YLPPKSTRRR AKVKTEEKVD VKTLVKSKSK KRRAAKNELE 70 80 90 100 110 120 ENVEFVRRFA PRRPYQWRGR QVRALPRPGI PVVFTPGQRS GVASKRSYDE VYADEDVLDQ 130 140 150 160 170 180 SGNMINEFAY GKRVKMLTHK NPTPSQVPIT PQEPIARPGE AGLLPTVQVL APRDSKHETM 190 200 210 220 230 240 LPVTKSEGGD VKVENKGFEQ ITPQLGVQTV DIKVPVKRKS EVEDEILKRA KMEPFETTVK 250 260 270 280 290 300 MEYSEQPQVE VFDTGVEPSS FFEVRSQARP IAVARKRRVP TVEVMEVQQS DHTAPTASAA 310 320 330 340 350 360 PVANVIVGPH LSRRPSRWGP ANAIYPDYVY HPSISAKKTM GPRPTGRVSR WGPANSIFPE 370 380 390 400 410 420 VRLHPSMVSA VTRAAPRKST KSRRRRRVRT RRAFVLPAGT KTGVMLPQNI RYHPSILFRR A

References

[1]	"DNA sequence and genomic organization of canine adenovirus type 1." Campbell J.B., Zhao Y. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U55001 Genomic DNA. Translation: AAB05440.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005608. Adeno_PV. [Graphical view]
Pfam	PF03910. Adeno_PV. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CORE5_ADECC

Accession

Primary (citable) accession number: Q65952

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program