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Protein

Protein FAM91A1

Gene

FAM91A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM91A1
Gene namesi
Name:FAM91A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26306. FAM91A1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671820.

Polymorphism and mutation databases

BioMutaiFAM91A1.
DMDMi212276508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Protein FAM91A1PRO_0000282552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321PhosphoserineCombined sources
Modified residuei340 – 3401PhosphoserineCombined sources
Modified residuei671 – 6711PhosphoserineCombined sources
Modified residuei828 – 8281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ658Y4.
MaxQBiQ658Y4.
PaxDbiQ658Y4.
PeptideAtlasiQ658Y4.
PRIDEiQ658Y4.

PTM databases

iPTMnetiQ658Y4.
PhosphoSiteiQ658Y4.

Expressioni

Gene expression databases

BgeeiENSG00000176853.
CleanExiHS_FAM91A1.
ExpressionAtlasiQ658Y4. baseline and differential.
GenevisibleiQ658Y4. HS.

Organism-specific databases

HPAiHPA027978.

Interactioni

Protein-protein interaction databases

BioGridi127622. 18 interactions.
IntActiQ658Y4. 6 interactions.
STRINGi9606.ENSP00000335082.

Structurei

3D structure databases

ProteinModelPortaliQ658Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM91 family.Curated

Phylogenomic databases

eggNOGiKOG3707. Eukaryota.
ENOG410XT0G. LUCA.
GeneTreeiENSGT00390000009543.
HOGENOMiHOG000006787.
HOVERGENiHBG105677.
InParanoidiQ658Y4.
OMAiKSTMDPQ.
OrthoDBiEOG091G011H.
PhylomeDBiQ658Y4.
TreeFamiTF314641.

Family and domain databases

InterProiIPR028097. FAM91_C_dom.
IPR028091. FAM91_N_dom.
[Graphical view]
PfamiPF14648. FAM91_C. 1 hit.
PF14647. FAM91_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q658Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN
60 70 80 90 100
NLVKHVKKDE RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG
110 120 130 140 150
IMEDIMNSEK SYDSLPNFTA ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR
160 170 180 190 200
KTARDLLPIK PVEIAIEAWW VVQAGYITED DIKICTLPEK CAVDKIIDSG
210 220 230 240 250
PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG FVMNRVQGDY
260 270 280 290 300
FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ
310 320 330 340 350
VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD
360 370 380 390 400
TDTNSQEDPA DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK
410 420 430 440 450
SHAVTMFEVG KLSDESLDSF LIELEKVQST GEGEAQRYFD HALTLRNTIL
460 470 480 490 500
FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE SLLGLDPATC SRVLNKNYTL
510 520 530 540 550
LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH VTGQGPPSLL
560 570 580 590 600
LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV
610 620 630 640 650
LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ
660 670 680 690 700
HLCGYVTMLN ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE
710 720 730 740 750
EATIDSATKQ TSGATTEADW VPLELCFGIP LFSSELNRKV CRKIAAHGLC
760 770 780 790 800
RKESLQNLLH SSRKLSLQVL NFVHSFQEGA SILDIHTEPS FSSLLSQSSC
810 820 830
ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ
Length:838
Mass (Da):93,909
Last modified:November 4, 2008 - v3
Checksum:i1F50F89A4BFB6B08
GO

Sequence cautioni

The sequence BAB85063 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti704 – 7041I → V.
Corresponds to variant rs6470187 [ dbSNP | Ensembl ].
VAR_057768
Natural varianti800 – 8001C → Y.3 Publications
Corresponds to variant rs1946586 [ dbSNP | Ensembl ].
VAR_067449

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228141 mRNA. Translation: ABB17070.1.
AC011134 Genomic DNA. No translation available.
AK074370 mRNA. Translation: BAB85063.1. Different initiation.
AL832830 mRNA. Translation: CAH56231.1.
AL832999 mRNA. Translation: CAH56297.1.
CCDSiCCDS6346.2.
RefSeqiNP_001304846.1. NM_001317917.1.
NP_001304847.1. NM_001317918.1.
NP_659400.2. NM_144963.3.
UniGeneiHs.459174.

Genome annotation databases

EnsembliENST00000334705; ENSP00000335082; ENSG00000176853.
GeneIDi157769.
KEGGihsa:157769.
UCSCiuc003yqv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228141 mRNA. Translation: ABB17070.1.
AC011134 Genomic DNA. No translation available.
AK074370 mRNA. Translation: BAB85063.1. Different initiation.
AL832830 mRNA. Translation: CAH56231.1.
AL832999 mRNA. Translation: CAH56297.1.
CCDSiCCDS6346.2.
RefSeqiNP_001304846.1. NM_001317917.1.
NP_001304847.1. NM_001317918.1.
NP_659400.2. NM_144963.3.
UniGeneiHs.459174.

3D structure databases

ProteinModelPortaliQ658Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127622. 18 interactions.
IntActiQ658Y4. 6 interactions.
STRINGi9606.ENSP00000335082.

PTM databases

iPTMnetiQ658Y4.
PhosphoSiteiQ658Y4.

Polymorphism and mutation databases

BioMutaiFAM91A1.
DMDMi212276508.

Proteomic databases

EPDiQ658Y4.
MaxQBiQ658Y4.
PaxDbiQ658Y4.
PeptideAtlasiQ658Y4.
PRIDEiQ658Y4.

Protocols and materials databases

DNASUi157769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334705; ENSP00000335082; ENSG00000176853.
GeneIDi157769.
KEGGihsa:157769.
UCSCiuc003yqv.4. human.

Organism-specific databases

CTDi157769.
GeneCardsiFAM91A1.
H-InvDBHIX0000998.
HIX0007769.
HGNCiHGNC:26306. FAM91A1.
HPAiHPA027978.
neXtProtiNX_Q658Y4.
PharmGKBiPA142671820.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3707. Eukaryota.
ENOG410XT0G. LUCA.
GeneTreeiENSGT00390000009543.
HOGENOMiHOG000006787.
HOVERGENiHBG105677.
InParanoidiQ658Y4.
OMAiKSTMDPQ.
OrthoDBiEOG091G011H.
PhylomeDBiQ658Y4.
TreeFamiTF314641.

Miscellaneous databases

GenomeRNAii157769.
PROiQ658Y4.

Gene expression databases

BgeeiENSG00000176853.
CleanExiHS_FAM91A1.
ExpressionAtlasiQ658Y4. baseline and differential.
GenevisibleiQ658Y4. HS.

Family and domain databases

InterProiIPR028097. FAM91_C_dom.
IPR028091. FAM91_N_dom.
[Graphical view]
PfamiPF14648. FAM91_C. 1 hit.
PF14647. FAM91_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF91A1_HUMAN
AccessioniPrimary (citable) accession number: Q658Y4
Secondary accession number(s): B6YY23, Q658T5, Q8TE89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 4, 2008
Last modified: September 7, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.