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Q658P3

- STEA3_HUMAN

UniProt

Q658P3 - STEA3_HUMAN

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Protein

Metalloreductase STEAP3

Gene

STEAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.2 Publications

Cofactori

FAD.By similarity
NADP.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADP1 Publication
Binding sitei38 – 381NADP; via amide nitrogen1 Publication
Binding sitei39 – 391NADP; via amide nitrogen1 Publication
Binding sitei58 – 581NADP1 Publication
Binding sitei59 – 591NADP1 Publication
Binding sitei91 – 911NADP; via carbonyl oxygen1 Publication
Binding sitei116 – 1161NADP; via amide nitrogen1 Publication
Binding sitei151 – 1511NADP; via amide nitrogen1 Publication
Metal bindingi316 – 3161Iron (heme axial ligand)Curated
Sitei325 – 3262Cleavage; by RHBDL4/RHBDD1Curated
Metal bindingi409 – 4091Iron (heme axial ligand)Curated

GO - Molecular functioni

  1. cupric reductase activity Source: Ensembl
  2. ferric-chelate reductase (NADPH) activity Source: Ensembl
  3. ferric-chelate reductase activity Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. cellular iron ion homeostasis Source: Reactome
  4. copper ion import Source: Ensembl
  5. exosomal secretion Source: Ensembl
  6. ferric iron import into cell Source: Ensembl
  7. positive regulation of apoptotic process Source: Ensembl
  8. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  9. protein secretion Source: UniProtKB
  10. transferrin transport Source: Reactome
  11. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis, Cell cycle, Ion transport, Iron transport, Transport

Keywords - Ligandi

Copper, FAD, Flavoprotein, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi9.B.66.1.1. the animal nonclassical protein secretion (nps) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP3 (EC:1.16.1.-)
Alternative name(s):
Dudulin-2
Six-transmembrane epithelial antigen of prostate 3
Tumor suppressor-activated pathway protein 6
Short name:
hTSAP6
pHyde
Short name:
hpHyde
Gene namesi
Name:STEAP3
Synonyms:TSAP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24592. STEAP3.

Subcellular locationi

Endosome membrane By similarity; Multi-pass membrane protein By similarity
Note: Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

GO - Cellular componenti

  1. endosome membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. multivesicular body Source: MGI
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi256 – 2561N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-344. 1 Publication
Mutagenesisi325 – 3251L → F: Strongly inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication
Mutagenesisi344 – 3441N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-256. 1 Publication

Organism-specific databases

MIMi615234. phenotype.
Orphaneti300298. Severe congenital hypochromic anemia with ringed sideroblasts.
PharmGKBiPA142670863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Metalloreductase STEAP3PRO_0000285171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei20 – 201PhosphoserineBy similarity
Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
Glycosylationi344 – 3441N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.1 Publication
Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ658P3.
PaxDbiQ658P3.
PRIDEiQ658P3.

PTM databases

PhosphoSiteiQ658P3.

Expressioni

Tissue specificityi

Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.3 Publications

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ658P3.
ExpressionAtlasiQ658P3. baseline and differential.
GenevestigatoriQ658P3.

Organism-specific databases

HPAiHPA050510.

Interactioni

Subunit structurei

Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.4 Publications

Protein-protein interaction databases

BioGridi120533. 13 interactions.
IntActiQ658P3. 2 interactions.

Structurei

Secondary structure

1
488
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 344
Helixi38 – 4912
Beta strandi54 – 607
Helixi61 – 677
Beta strandi72 – 765
Helixi77 – 804
Beta strandi85 – 895
Helixi93 – 953
Helixi97 – 1026
Helixi103 – 1064
Beta strandi110 – 1134
Helixi119 – 1246
Helixi129 – 1368
Beta strandi140 – 1456
Helixi151 – 1555
Beta strandi164 – 1707
Helixi172 – 18413
Beta strandi188 – 1914
Helixi195 – 1973
Helixi198 – 2036

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VNSX-ray2.00A/B1-215[»]
2VQ3X-ray2.00A/B1-215[»]
ProteinModelPortaliQ658P3.
SMRiQ658P3. Positions 29-209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ658P3.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 207207CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini229 – 25830VesicularSequence AnalysisAdd
BLAST
Topological domaini280 – 30425CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini326 – 35833VesicularSequence AnalysisAdd
BLAST
Topological domaini380 – 39011CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini412 – 43322VesicularSequence AnalysisAdd
BLAST
Topological domaini455 – 48834CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 407149Ferric oxidoreductaseAdd
BLAST

Sequence similaritiesi

Belongs to the STEAP family.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2085.
GeneTreeiENSGT00390000008042.
HOVERGENiHBG054379.
InParanoidiQ658P3.
KOiK10142.
OMAiGWKVPAL.
OrthoDBiEOG7Z0JWH.
PhylomeDBiQ658P3.
TreeFamiTF332031.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view]
PfamiPF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q658P3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS
60 70 80 90 100
GFKVVVGSRN PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC
110 120 130 140 150
SLSDQLAGKI LVDVSNPTEQ EHLQHRESNA EYLASLFPTC TVVKAFNVIS
160 170 180 190 200
AWTLQAGPRD GNRQVPICGD QPEAKRAVSE MALAMGFMPV DMGSLASAWE
210 220 230 240 250
VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV QESQNKFFKL
260 270 280 290 300
PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ
310 320 330 340 350
HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV
360 370 380 390 400
EEEVWRMEIY LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF
410 420 430 440 450
VALVLSTLHT LTYGWTRAFE ESRYKFYLPP TFTLTLLVPC VVILAKALFL
460 470 480
LPCISRRLAR IRRGWEREST IKFTLPTDHA LAEKTSHV
Length:488
Mass (Da):54,601
Last modified:May 1, 2007 - v2
Checksum:iC89EB0D0430F9BFB
GO
Isoform 2 (identifier: Q658P3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSHQPAVATKM

Show »
Length:498
Mass (Da):55,652
Checksum:i69DD201AA00C2D6B
GO
Isoform 3 (identifier: Q658P3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: Missing.

Show »
Length:487
Mass (Da):54,472
Checksum:i4A279EE7C8964412
GO
Isoform 4 (identifier: Q658P3-4) [UniParc]FASTAAdd to Basket

Also known as: pHyde II

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: Missing.
     396-488: SSLGFVALVL...HALAEKTSHV → CVATSSAGNT...GHQEDLSWTR

Show »
Length:456
Mass (Da):50,499
Checksum:i2ECEEB9C1515A9B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321G → S in AAL78206. (PubMed:10969787)Curated
Sequence conflicti32 – 321G → S in AAM08128. (PubMed:10969787)Curated
Sequence conflicti32 – 321G → S in AAM45136. (PubMed:14702039)Curated
Sequence conflicti68 – 681F → Y in AAK50538. 1 PublicationCurated
Sequence conflicti68 – 681F → Y in BAA91839. (PubMed:17974005)Curated
Sequence conflicti163 – 1631R → G in AAL78206. (PubMed:10969787)Curated
Sequence conflicti163 – 1631R → G in AAM08128. (PubMed:10969787)Curated
Sequence conflicti478 – 4781D → G in CAD97986. (PubMed:15815621)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841A → T.
Corresponds to variant rs17013371 [ dbSNP | Ensembl ].
VAR_031975

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSHQPAVATKM in isoform 2. 2 PublicationsVSP_024829
Alternative sequencei351 – 3511Missing in isoform 3 and isoform 4. 2 PublicationsVSP_024830
Alternative sequencei396 – 48893SSLGF…KTSHV → CVATSSAGNTGSGTRRPESQ SQDPHLPAPHHQTSFLGPRS FCCSLVPVSTPYGHQEDLSW TR in isoform 4. 1 PublicationVSP_024831Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214461 mRNA. Translation: AAO38238.1.
AF423424 mRNA. Translation: AAQ04065.1.
AF238864 mRNA. Translation: AAL78206.1.
AF262322 mRNA. Translation: AAM08128.1.
AY029585 mRNA. Translation: AAK50538.1.
AY082673 mRNA. Translation: AAM45136.1.
AK001691 mRNA. Translation: BAA91839.1.
AK291608 mRNA. Translation: BAF84297.1.
AL833624 mRNA. Translation: CAH56204.1.
BX538047 mRNA. Translation: CAD97986.1.
AC016673 Genomic DNA. Translation: AAX88963.1.
AC016736 Genomic DNA. Translation: AAY14872.1.
CH471103 Genomic DNA. Translation: EAW95209.1.
BC042150 mRNA. Translation: AAH42150.1.
BC095421 mRNA. Translation: AAH95421.2.
CCDSiCCDS2125.1. [Q658P3-1]
CCDS42738.1. [Q658P3-2]
RefSeqiNP_001008410.1. NM_001008410.1. [Q658P3-1]
NP_060704.2. NM_018234.2. [Q658P3-1]
NP_878919.2. NM_182915.2. [Q658P3-2]
XP_006712676.1. XM_006712613.1. [Q658P3-1]
XP_006712677.1. XM_006712614.1. [Q658P3-1]
XP_006712678.1. XM_006712615.1. [Q658P3-1]
UniGeneiHs.647822.

Genome annotation databases

EnsembliENST00000393106; ENSP00000376818; ENSG00000115107. [Q658P3-1]
ENST00000393107; ENSP00000376819; ENSG00000115107. [Q658P3-1]
ENST00000393110; ENSP00000376822; ENSG00000115107. [Q658P3-2]
GeneIDi55240.
KEGGihsa:55240.
UCSCiuc002tlp.3. human. [Q658P3-1]
uc002tlq.3. human. [Q658P3-2]

Polymorphism databases

DMDMi146325737.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY214461 mRNA. Translation: AAO38238.1 .
AF423424 mRNA. Translation: AAQ04065.1 .
AF238864 mRNA. Translation: AAL78206.1 .
AF262322 mRNA. Translation: AAM08128.1 .
AY029585 mRNA. Translation: AAK50538.1 .
AY082673 mRNA. Translation: AAM45136.1 .
AK001691 mRNA. Translation: BAA91839.1 .
AK291608 mRNA. Translation: BAF84297.1 .
AL833624 mRNA. Translation: CAH56204.1 .
BX538047 mRNA. Translation: CAD97986.1 .
AC016673 Genomic DNA. Translation: AAX88963.1 .
AC016736 Genomic DNA. Translation: AAY14872.1 .
CH471103 Genomic DNA. Translation: EAW95209.1 .
BC042150 mRNA. Translation: AAH42150.1 .
BC095421 mRNA. Translation: AAH95421.2 .
CCDSi CCDS2125.1. [Q658P3-1 ]
CCDS42738.1. [Q658P3-2 ]
RefSeqi NP_001008410.1. NM_001008410.1. [Q658P3-1 ]
NP_060704.2. NM_018234.2. [Q658P3-1 ]
NP_878919.2. NM_182915.2. [Q658P3-2 ]
XP_006712676.1. XM_006712613.1. [Q658P3-1 ]
XP_006712677.1. XM_006712614.1. [Q658P3-1 ]
XP_006712678.1. XM_006712615.1. [Q658P3-1 ]
UniGenei Hs.647822.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VNS X-ray 2.00 A/B 1-215 [» ]
2VQ3 X-ray 2.00 A/B 1-215 [» ]
ProteinModelPortali Q658P3.
SMRi Q658P3. Positions 29-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120533. 13 interactions.
IntActi Q658P3. 2 interactions.

Protein family/group databases

TCDBi 9.B.66.1.1. the animal nonclassical protein secretion (nps) family.

PTM databases

PhosphoSitei Q658P3.

Polymorphism databases

DMDMi 146325737.

Proteomic databases

MaxQBi Q658P3.
PaxDbi Q658P3.
PRIDEi Q658P3.

Protocols and materials databases

DNASUi 55240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393106 ; ENSP00000376818 ; ENSG00000115107 . [Q658P3-1 ]
ENST00000393107 ; ENSP00000376819 ; ENSG00000115107 . [Q658P3-1 ]
ENST00000393110 ; ENSP00000376822 ; ENSG00000115107 . [Q658P3-2 ]
GeneIDi 55240.
KEGGi hsa:55240.
UCSCi uc002tlp.3. human. [Q658P3-1 ]
uc002tlq.3. human. [Q658P3-2 ]

Organism-specific databases

CTDi 55240.
GeneCardsi GC02P119981.
HGNCi HGNC:24592. STEAP3.
HPAi HPA050510.
MIMi 609671. gene.
615234. phenotype.
neXtProti NX_Q658P3.
Orphaneti 300298. Severe congenital hypochromic anemia with ringed sideroblasts.
PharmGKBi PA142670863.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2085.
GeneTreei ENSGT00390000008042.
HOVERGENi HBG054379.
InParanoidi Q658P3.
KOi K10142.
OMAi GWKVPAL.
OrthoDBi EOG7Z0JWH.
PhylomeDBi Q658P3.
TreeFami TF332031.

Enzyme and pathway databases

Reactomei REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi STEAP3. human.
EvolutionaryTracei Q658P3.
GeneWikii STEAP3.
GenomeRNAii 55240.
NextBioi 59270.
PROi Q658P3.
SOURCEi Search...

Gene expression databases

Bgeei Q658P3.
ExpressionAtlasi Q658P3. baseline and differential.
Genevestigatori Q658P3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view ]
Pfami PF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH BNIP3L AND MYT1.
  2. "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer."
    Korkmaz C.G., Korkmaz K.S., Kurys P., Elbi C., Wang L., Klokk T.I., Hammarstrom C., Troen G., Svindland A., Hager G.L., Saatcioglu F.
    Oncogene 24:4934-4945(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde."
    Steiner M.S., Zhang X., Wang Y., Lu Y.
    Cancer Res. 60:4419-4425(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  4. "Dudulin 2, a new tumor antigen expressed in various human tumors."
    Serru V., Manivet P., Lenoir C., Eschwege P., Lamblin D., Vaubourdolle M., Kellermann O., Loric S.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Characterization of a novel apoptosis-inducing gene, hpHyde, that inhibits prostate cancer cell growth."
    Lu Y., Beheshti B., Squire J.A., Yang X.J.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon endothelium and Endometrial adenocarcinoma.
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  11. "Human pHyde is not a classical tumor suppressor gene in prostate cancer."
    Porkka K.P., Nupponen N.N., Tammela T.L., Vessella R.L., Visakorpi T.
    Int. J. Cancer 106:729-735(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF TUMOR SUPPRESSOR FUNCTION.
  12. "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway."
    Amzallag N., Passer B.J., Allanic D., Segura E., Thery C., Goud B., Amson R., Telerman A.
    J. Biol. Chem. 279:46104-46112(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TCTP.
  13. "Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition."
    Coulouarn C., Derambure C., Lefebvre G., Daveau R., Hiron M., Scotte M., Francois A., Daveau M., Salier J.-P.
    J. Hepatol. 42:860-869(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells."
    Ohgami R.S., Campagna D.R., Greer E.L., Antiochos B., McDonald A., Chen J., Sharp J.J., Fujiwara Y., Barker J.E., Fleming M.D.
    Nat. Genet. 37:1264-1269(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "The regulation of exosome secretion: a novel function of the p53 protein."
    Yu X., Harris S.L., Levine A.J.
    Cancer Res. 66:4795-4801(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene."
    Grandchamp B., Hetet G., Kannengiesser C., Oudin C., Beaumont C., Rodrigues-Ferreira S., Amson R., Telerman A., Nielsen P., Kohne E., Balser C., Heimpel H.
    Blood 118:6660-6666(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN AHMIO2.
  17. "Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis."
    Wan C., Fu J., Wang Y., Miao S., Song W., Wang L.
    PLoS ONE 7:E37452-E37452(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY RHBDD1, INTERACTION WITH RHBDD1, GLYCOSYLATION AT ASN-256 AND ASN-344, MUTAGENESIS OF ASN-256; LEU-325 AND ASN-344.
  18. "Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle."
    Sendamarai A.K., Ohgami R.S., Fleming M.D., Lawrence C.M.
    Proc. Natl. Acad. Sci. U.S.A. 105:7410-7415(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-215 ALONE AND IN COMPLEX WITH NADPH, COFACTOR, SUBUNIT.

Entry informationi

Entry nameiSTEA3_HUMAN
AccessioniPrimary (citable) accession number: Q658P3
Secondary accession number(s): A8K6E3
, Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6, Q8TDP3, Q8TF03, Q9NVB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3