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Q658P3

- STEA3_HUMAN

UniProt

Q658P3 - STEA3_HUMAN

Protein

Metalloreductase STEAP3

Gene

STEAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.2 Publications

    Cofactori

    FAD.By similarity
    NADP.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADP1 Publication
    Binding sitei38 – 381NADP; via amide nitrogen1 Publication
    Binding sitei39 – 391NADP; via amide nitrogen1 Publication
    Binding sitei58 – 581NADP1 Publication
    Binding sitei59 – 591NADP1 Publication
    Binding sitei91 – 911NADP; via carbonyl oxygen1 Publication
    Binding sitei116 – 1161NADP; via amide nitrogen1 Publication
    Binding sitei151 – 1511NADP; via amide nitrogen1 Publication
    Metal bindingi316 – 3161Iron (heme axial ligand)Curated
    Sitei325 – 3262Cleavage; by RHBDL4/RHBDD1Curated
    Metal bindingi409 – 4091Iron (heme axial ligand)Curated

    GO - Molecular functioni

    1. ferric-chelate reductase activity Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. cellular iron ion homeostasis Source: Reactome
    4. positive regulation of apoptotic process Source: Ensembl
    5. protein secretion Source: UniProtKB
    6. transferrin transport Source: Reactome
    7. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Apoptosis, Cell cycle, Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Copper, FAD, Flavoprotein, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    ReactomeiREACT_25283. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi9.B.66.1.1. the animal nonclassical protein secretion (nps) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metalloreductase STEAP3 (EC:1.16.1.-)
    Alternative name(s):
    Dudulin-2
    Six-transmembrane epithelial antigen of prostate 3
    Tumor suppressor-activated pathway protein 6
    Short name:
    hTSAP6
    pHyde
    Short name:
    hpHyde
    Gene namesi
    Name:STEAP3
    Synonyms:TSAP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24592. STEAP3.

    Subcellular locationi

    Endosome membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

    GO - Cellular componenti

    1. endosome membrane Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW
    3. multivesicular body Source: MGI
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi256 – 2561N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-344. 1 Publication
    Mutagenesisi325 – 3251L → F: Strongly inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication
    Mutagenesisi344 – 3441N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-256. 1 Publication

    Organism-specific databases

    MIMi615234. phenotype.
    Orphaneti300298. Severe congenital hypochromic anemia with ringed sideroblasts.
    PharmGKBiPA142670863.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Metalloreductase STEAP3PRO_0000285171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171PhosphoserineBy similarity
    Modified residuei20 – 201PhosphoserineBy similarity
    Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
    Glycosylationi344 – 3441N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.1 Publication
    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ658P3.
    PaxDbiQ658P3.
    PRIDEiQ658P3.

    PTM databases

    PhosphoSiteiQ658P3.

    Expressioni

    Tissue specificityi

    Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.3 Publications

    Inductioni

    By p53/TP53.1 Publication

    Gene expression databases

    ArrayExpressiQ658P3.
    BgeeiQ658P3.
    GenevestigatoriQ658P3.

    Organism-specific databases

    HPAiHPA050510.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.4 Publications

    Protein-protein interaction databases

    BioGridi120533. 5 interactions.
    IntActiQ658P3. 2 interactions.

    Structurei

    Secondary structure

    1
    488
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 344
    Helixi38 – 4912
    Beta strandi54 – 607
    Helixi61 – 677
    Beta strandi72 – 765
    Helixi77 – 804
    Beta strandi85 – 895
    Helixi93 – 953
    Helixi97 – 1026
    Helixi103 – 1064
    Beta strandi110 – 1134
    Helixi119 – 1246
    Helixi129 – 1368
    Beta strandi140 – 1456
    Helixi151 – 1555
    Beta strandi164 – 1707
    Helixi172 – 18413
    Beta strandi188 – 1914
    Helixi195 – 1973
    Helixi198 – 2036

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VNSX-ray2.00A/B1-215[»]
    2VQ3X-ray2.00A/B1-215[»]
    ProteinModelPortaliQ658P3.
    SMRiQ658P3. Positions 29-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ658P3.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 207207CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini229 – 25830VesicularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini326 – 35833VesicularSequence AnalysisAdd
    BLAST
    Topological domaini380 – 39011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini412 – 43322VesicularSequence AnalysisAdd
    BLAST
    Topological domaini455 – 48834CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini259 – 407149Ferric oxidoreductaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the STEAP family.Curated
    Contains 1 ferric oxidoreductase domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2085.
    HOVERGENiHBG054379.
    InParanoidiQ658P3.
    KOiK10142.
    OMAiGWKVPAL.
    OrthoDBiEOG7Z0JWH.
    PhylomeDBiQ658P3.
    TreeFamiTF332031.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR013130. Fe3_Rdtase_TM_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR028939. ProC_N.
    [Graphical view]
    PfamiPF03807. F420_oxidored. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q658P3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS    50
    GFKVVVGSRN PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC 100
    SLSDQLAGKI LVDVSNPTEQ EHLQHRESNA EYLASLFPTC TVVKAFNVIS 150
    AWTLQAGPRD GNRQVPICGD QPEAKRAVSE MALAMGFMPV DMGSLASAWE 200
    VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV QESQNKFFKL 250
    PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ 300
    HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV 350
    EEEVWRMEIY LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF 400
    VALVLSTLHT LTYGWTRAFE ESRYKFYLPP TFTLTLLVPC VVILAKALFL 450
    LPCISRRLAR IRRGWEREST IKFTLPTDHA LAEKTSHV 488
    Length:488
    Mass (Da):54,601
    Last modified:May 1, 2007 - v2
    Checksum:iC89EB0D0430F9BFB
    GO
    Isoform 2 (identifier: Q658P3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSHQPAVATKM

    Show »
    Length:498
    Mass (Da):55,652
    Checksum:i69DD201AA00C2D6B
    GO
    Isoform 3 (identifier: Q658P3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-351: Missing.

    Show »
    Length:487
    Mass (Da):54,472
    Checksum:i4A279EE7C8964412
    GO
    Isoform 4 (identifier: Q658P3-4) [UniParc]FASTAAdd to Basket

    Also known as: pHyde II

    The sequence of this isoform differs from the canonical sequence as follows:
         351-351: Missing.
         396-488: SSLGFVALVL...HALAEKTSHV → CVATSSAGNT...GHQEDLSWTR

    Show »
    Length:456
    Mass (Da):50,499
    Checksum:i2ECEEB9C1515A9B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321G → S in AAL78206. (PubMed:10969787)Curated
    Sequence conflicti32 – 321G → S in AAM08128. (PubMed:10969787)Curated
    Sequence conflicti32 – 321G → S in AAM45136. (PubMed:14702039)Curated
    Sequence conflicti68 – 681F → Y in AAK50538. 1 PublicationCurated
    Sequence conflicti68 – 681F → Y in BAA91839. (PubMed:17974005)Curated
    Sequence conflicti163 – 1631R → G in AAL78206. (PubMed:10969787)Curated
    Sequence conflicti163 – 1631R → G in AAM08128. (PubMed:10969787)Curated
    Sequence conflicti478 – 4781D → G in CAD97986. (PubMed:15815621)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841A → T.
    Corresponds to variant rs17013371 [ dbSNP | Ensembl ].
    VAR_031975

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MSHQPAVATKM in isoform 2. 2 PublicationsVSP_024829
    Alternative sequencei351 – 3511Missing in isoform 3 and isoform 4. 2 PublicationsVSP_024830
    Alternative sequencei396 – 48893SSLGF…KTSHV → CVATSSAGNTGSGTRRPESQ SQDPHLPAPHHQTSFLGPRS FCCSLVPVSTPYGHQEDLSW TR in isoform 4. 1 PublicationVSP_024831Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214461 mRNA. Translation: AAO38238.1.
    AF423424 mRNA. Translation: AAQ04065.1.
    AF238864 mRNA. Translation: AAL78206.1.
    AF262322 mRNA. Translation: AAM08128.1.
    AY029585 mRNA. Translation: AAK50538.1.
    AY082673 mRNA. Translation: AAM45136.1.
    AK001691 mRNA. Translation: BAA91839.1.
    AK291608 mRNA. Translation: BAF84297.1.
    AL833624 mRNA. Translation: CAH56204.1.
    BX538047 mRNA. Translation: CAD97986.1.
    AC016673 Genomic DNA. Translation: AAX88963.1.
    AC016736 Genomic DNA. Translation: AAY14872.1.
    CH471103 Genomic DNA. Translation: EAW95209.1.
    BC042150 mRNA. Translation: AAH42150.1.
    BC095421 mRNA. Translation: AAH95421.2.
    CCDSiCCDS2125.1. [Q658P3-1]
    CCDS42738.1. [Q658P3-2]
    RefSeqiNP_001008410.1. NM_001008410.1. [Q658P3-1]
    NP_060704.2. NM_018234.2. [Q658P3-1]
    NP_878919.2. NM_182915.2. [Q658P3-2]
    XP_006712676.1. XM_006712613.1. [Q658P3-1]
    XP_006712677.1. XM_006712614.1. [Q658P3-1]
    XP_006712678.1. XM_006712615.1. [Q658P3-1]
    UniGeneiHs.647822.

    Genome annotation databases

    EnsembliENST00000393106; ENSP00000376818; ENSG00000115107. [Q658P3-1]
    ENST00000393107; ENSP00000376819; ENSG00000115107. [Q658P3-1]
    ENST00000393110; ENSP00000376822; ENSG00000115107. [Q658P3-2]
    GeneIDi55240.
    KEGGihsa:55240.
    UCSCiuc002tlp.3. human. [Q658P3-1]
    uc002tlq.3. human. [Q658P3-2]

    Polymorphism databases

    DMDMi146325737.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214461 mRNA. Translation: AAO38238.1 .
    AF423424 mRNA. Translation: AAQ04065.1 .
    AF238864 mRNA. Translation: AAL78206.1 .
    AF262322 mRNA. Translation: AAM08128.1 .
    AY029585 mRNA. Translation: AAK50538.1 .
    AY082673 mRNA. Translation: AAM45136.1 .
    AK001691 mRNA. Translation: BAA91839.1 .
    AK291608 mRNA. Translation: BAF84297.1 .
    AL833624 mRNA. Translation: CAH56204.1 .
    BX538047 mRNA. Translation: CAD97986.1 .
    AC016673 Genomic DNA. Translation: AAX88963.1 .
    AC016736 Genomic DNA. Translation: AAY14872.1 .
    CH471103 Genomic DNA. Translation: EAW95209.1 .
    BC042150 mRNA. Translation: AAH42150.1 .
    BC095421 mRNA. Translation: AAH95421.2 .
    CCDSi CCDS2125.1. [Q658P3-1 ]
    CCDS42738.1. [Q658P3-2 ]
    RefSeqi NP_001008410.1. NM_001008410.1. [Q658P3-1 ]
    NP_060704.2. NM_018234.2. [Q658P3-1 ]
    NP_878919.2. NM_182915.2. [Q658P3-2 ]
    XP_006712676.1. XM_006712613.1. [Q658P3-1 ]
    XP_006712677.1. XM_006712614.1. [Q658P3-1 ]
    XP_006712678.1. XM_006712615.1. [Q658P3-1 ]
    UniGenei Hs.647822.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VNS X-ray 2.00 A/B 1-215 [» ]
    2VQ3 X-ray 2.00 A/B 1-215 [» ]
    ProteinModelPortali Q658P3.
    SMRi Q658P3. Positions 29-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120533. 5 interactions.
    IntActi Q658P3. 2 interactions.

    Protein family/group databases

    TCDBi 9.B.66.1.1. the animal nonclassical protein secretion (nps) family.

    PTM databases

    PhosphoSitei Q658P3.

    Polymorphism databases

    DMDMi 146325737.

    Proteomic databases

    MaxQBi Q658P3.
    PaxDbi Q658P3.
    PRIDEi Q658P3.

    Protocols and materials databases

    DNASUi 55240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393106 ; ENSP00000376818 ; ENSG00000115107 . [Q658P3-1 ]
    ENST00000393107 ; ENSP00000376819 ; ENSG00000115107 . [Q658P3-1 ]
    ENST00000393110 ; ENSP00000376822 ; ENSG00000115107 . [Q658P3-2 ]
    GeneIDi 55240.
    KEGGi hsa:55240.
    UCSCi uc002tlp.3. human. [Q658P3-1 ]
    uc002tlq.3. human. [Q658P3-2 ]

    Organism-specific databases

    CTDi 55240.
    GeneCardsi GC02P119981.
    HGNCi HGNC:24592. STEAP3.
    HPAi HPA050510.
    MIMi 609671. gene.
    615234. phenotype.
    neXtProti NX_Q658P3.
    Orphaneti 300298. Severe congenital hypochromic anemia with ringed sideroblasts.
    PharmGKBi PA142670863.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2085.
    HOVERGENi HBG054379.
    InParanoidi Q658P3.
    KOi K10142.
    OMAi GWKVPAL.
    OrthoDBi EOG7Z0JWH.
    PhylomeDBi Q658P3.
    TreeFami TF332031.

    Enzyme and pathway databases

    Reactomei REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi STEAP3. human.
    EvolutionaryTracei Q658P3.
    GeneWikii STEAP3.
    GenomeRNAii 55240.
    NextBioi 59270.
    PROi Q658P3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q658P3.
    Bgeei Q658P3.
    Genevestigatori Q658P3.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR013130. Fe3_Rdtase_TM_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR028939. ProC_N.
    [Graphical view ]
    Pfami PF03807. F420_oxidored. 1 hit.
    PF01794. Ferric_reduct. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH BNIP3L AND MYT1.
    2. "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer."
      Korkmaz C.G., Korkmaz K.S., Kurys P., Elbi C., Wang L., Klokk T.I., Hammarstrom C., Troen G., Svindland A., Hager G.L., Saatcioglu F.
      Oncogene 24:4934-4945(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde."
      Steiner M.S., Zhang X., Wang Y., Lu Y.
      Cancer Res. 60:4419-4425(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    4. "Dudulin 2, a new tumor antigen expressed in various human tumors."
      Serru V., Manivet P., Lenoir C., Eschwege P., Lamblin D., Vaubourdolle M., Kellermann O., Loric S.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Characterization of a novel apoptosis-inducing gene, hpHyde, that inhibits prostate cancer cell growth."
      Lu Y., Beheshti B., Squire J.A., Yang X.J.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon endothelium and Endometrial adenocarcinoma.
    8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    11. "Human pHyde is not a classical tumor suppressor gene in prostate cancer."
      Porkka K.P., Nupponen N.N., Tammela T.L., Vessella R.L., Visakorpi T.
      Int. J. Cancer 106:729-735(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF TUMOR SUPPRESSOR FUNCTION.
    12. "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway."
      Amzallag N., Passer B.J., Allanic D., Segura E., Thery C., Goud B., Amson R., Telerman A.
      J. Biol. Chem. 279:46104-46112(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TCTP.
    13. "Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition."
      Coulouarn C., Derambure C., Lefebvre G., Daveau R., Hiron M., Scotte M., Francois A., Daveau M., Salier J.-P.
      J. Hepatol. 42:860-869(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    14. "Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells."
      Ohgami R.S., Campagna D.R., Greer E.L., Antiochos B., McDonald A., Chen J., Sharp J.J., Fujiwara Y., Barker J.E., Fleming M.D.
      Nat. Genet. 37:1264-1269(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    15. "The regulation of exosome secretion: a novel function of the p53 protein."
      Yu X., Harris S.L., Levine A.J.
      Cancer Res. 66:4795-4801(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene."
      Grandchamp B., Hetet G., Kannengiesser C., Oudin C., Beaumont C., Rodrigues-Ferreira S., Amson R., Telerman A., Nielsen P., Kohne E., Balser C., Heimpel H.
      Blood 118:6660-6666(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN AHMIO2.
    17. "Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis."
      Wan C., Fu J., Wang Y., Miao S., Song W., Wang L.
      PLoS ONE 7:E37452-E37452(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY RHBDD1, INTERACTION WITH RHBDD1, GLYCOSYLATION AT ASN-256 AND ASN-344, MUTAGENESIS OF ASN-256; LEU-325 AND ASN-344.
    18. "Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle."
      Sendamarai A.K., Ohgami R.S., Fleming M.D., Lawrence C.M.
      Proc. Natl. Acad. Sci. U.S.A. 105:7410-7415(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-215 ALONE AND IN COMPLEX WITH NADPH, COFACTOR, SUBUNIT.

    Entry informationi

    Entry nameiSTEA3_HUMAN
    AccessioniPrimary (citable) accession number: Q658P3
    Secondary accession number(s): A8K6E3
    , Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6, Q8TDP3, Q8TF03, Q9NVB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3