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Protein

WSC domain-containing protein 1

Gene

WSCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
WSC domain-containing protein 1
Gene namesi
Name:WSCD1
Synonyms:KIAA0523
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000179314.13
HGNCiHGNC:29060 WSCD1
neXtProtiNX_Q658N2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23302
OpenTargetsiENSG00000179314
PharmGKBiPA162409253

Polymorphism and mutation databases

BioMutaiWSCD1
DMDMi74724420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050611 – 575WSC domain-containing protein 1Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ658N2
PeptideAtlasiQ658N2
PRIDEiQ658N2

PTM databases

iPTMnetiQ658N2
PhosphoSitePlusiQ658N2

Expressioni

Gene expression databases

BgeeiENSG00000179314
CleanExiHS_WSCD1
ExpressionAtlasiQ658N2 baseline and differential
GenevisibleiQ658N2 HS

Organism-specific databases

HPAiHPA015919

Structurei

3D structure databases

ProteinModelPortaliQ658N2
SMRiQ658N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 234WSC 1PROSITE-ProRule annotationAdd BLAST93
Domaini245 – 340WSC 2PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the WSCD family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR06 Eukaryota
ENOG4111D3F LUCA
GeneTreeiENSGT00390000012250
HOGENOMiHOG000060082
HOVERGENiHBG102242
InParanoidiQ658N2
OMAiWSSHVLD
OrthoDBiEOG091G03QE
PhylomeDBiQ658N2
TreeFamiTF324060

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
PF01822 WSC, 2 hits
SMARTiView protein in SMART
SM00321 WSC, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51212 WSC, 2 hits

Sequencei

Sequence statusi: Complete.

Q658N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRVRV ALPQGPRAPG
60 70 80 90 100
PLQTLPVAAV ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR
110 120 130 140 150
WLRSRNSELR QLRRRWFHHF MSDSQGPPAL GPEAARPAIH SRGTYIGCFS
160 170 180 190 200
DDGHERTLKG AVFYDLRKMT VSHCQDACAE RSYVYAGLEA GAECYCGNRL
210 220 230 240 250
PAVSVGLEEC NHECKGEKGS VCGAVDRLSV YRVDELQPGS RKRRTATYRG
260 270 280 290 300
CFRLPENITH AFPSSLIQAN VTVGTCSGFC SQKEFPLAIL RGWECYCAYP
310 320 330 340 350
TPRFNLRDAM DSSVCGQDPE AQRLAEYCEV YQTPVQDTRC TDRRFLPNKS
360 370 380 390 400
KVFVALSSFP GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW
410 420 430 440 450
RSRRTICVKT HESGRREIEM FDSAILLIRN PYRSLVAEFN RKCAGHLGYA
460 470 480 490 500
ADRNWKSKEW PDFVNSYASW WSSHVLDWLK YGKRLLVVHY EELRRSLVPT
510 520 530 540 550
LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP FTPEMKDLIN
560 570
GYIRTVDQAL RDHNWTGLPR EYVPR
Length:575
Mass (Da):65,694
Last modified:October 25, 2004 - v1
Checksum:iA672F406EFDE849B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035160212H → Y1 PublicationCorresponds to variant dbSNP:rs17855415Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289603 mRNA Translation: BAF82292.1
AL833730 mRNA Translation: CAH56249.1
CH471108 Genomic DNA Translation: EAW90316.1
CH471108 Genomic DNA Translation: EAW90317.1
BC009975 mRNA Translation: AAH09975.1
AB011095 mRNA Translation: BAA25449.1
CCDSiCCDS32538.1
RefSeqiNP_056068.1, NM_015253.1
XP_005256629.1, XM_005256572.1
XP_005256630.1, XM_005256573.1
UniGeneiHs.370166

Genome annotation databases

EnsembliENST00000317744; ENSP00000323087; ENSG00000179314
ENST00000539421; ENSP00000446032; ENSG00000179314
ENST00000574232; ENSP00000458374; ENSG00000179314
ENST00000574946; ENSP00000460825; ENSG00000179314
GeneIDi23302
KEGGihsa:23302
UCSCiuc002gcn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWSCD1_HUMAN
AccessioniPrimary (citable) accession number: Q658N2
Secondary accession number(s): A8K0N8
, D3DTM3, O60276, Q96G45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health