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Protein

WSC domain-containing protein 1

Gene

WSCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WSC domain-containing protein 1
Gene namesi
Name:WSCD1
Synonyms:KIAA0523
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29060. WSCD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409253.

Polymorphism and mutation databases

BioMutaiWSCD1.
DMDMi74724420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575WSC domain-containing protein 1PRO_0000305061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ658N2.
PRIDEiQ658N2.

PTM databases

PhosphoSiteiQ658N2.

Expressioni

Gene expression databases

BgeeiQ658N2.
CleanExiHS_WSCD1.
ExpressionAtlasiQ658N2. baseline and differential.
GenevisibleiQ658N2. HS.

Organism-specific databases

HPAiHPA015919.

Structurei

3D structure databases

ProteinModelPortaliQ658N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 23493WSC 1PROSITE-ProRule annotationAdd
BLAST
Domaini245 – 34096WSC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WSCD family.Curated
Contains 2 WSC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR06. Eukaryota.
ENOG4111D3F. LUCA.
GeneTreeiENSGT00390000012250.
HOGENOMiHOG000060082.
HOVERGENiHBG102242.
InParanoidiQ658N2.
OMAiSKEWPDF.
OrthoDBiEOG7QZG95.
PhylomeDBiQ658N2.
TreeFamiTF324060.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
PF01822. WSC. 2 hits.
[Graphical view]
SMARTiSM00321. WSC. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51212. WSC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q658N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRVRV ALPQGPRAPG
60 70 80 90 100
PLQTLPVAAV ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR
110 120 130 140 150
WLRSRNSELR QLRRRWFHHF MSDSQGPPAL GPEAARPAIH SRGTYIGCFS
160 170 180 190 200
DDGHERTLKG AVFYDLRKMT VSHCQDACAE RSYVYAGLEA GAECYCGNRL
210 220 230 240 250
PAVSVGLEEC NHECKGEKGS VCGAVDRLSV YRVDELQPGS RKRRTATYRG
260 270 280 290 300
CFRLPENITH AFPSSLIQAN VTVGTCSGFC SQKEFPLAIL RGWECYCAYP
310 320 330 340 350
TPRFNLRDAM DSSVCGQDPE AQRLAEYCEV YQTPVQDTRC TDRRFLPNKS
360 370 380 390 400
KVFVALSSFP GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW
410 420 430 440 450
RSRRTICVKT HESGRREIEM FDSAILLIRN PYRSLVAEFN RKCAGHLGYA
460 470 480 490 500
ADRNWKSKEW PDFVNSYASW WSSHVLDWLK YGKRLLVVHY EELRRSLVPT
510 520 530 540 550
LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP FTPEMKDLIN
560 570
GYIRTVDQAL RDHNWTGLPR EYVPR
Length:575
Mass (Da):65,694
Last modified:October 25, 2004 - v1
Checksum:iA672F406EFDE849B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121H → Y.1 Publication
Corresponds to variant rs17855415 [ dbSNP | Ensembl ].
VAR_035160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289603 mRNA. Translation: BAF82292.1.
AL833730 mRNA. Translation: CAH56249.1.
CH471108 Genomic DNA. Translation: EAW90316.1.
CH471108 Genomic DNA. Translation: EAW90317.1.
BC009975 mRNA. Translation: AAH09975.1.
AB011095 mRNA. Translation: BAA25449.1.
CCDSiCCDS32538.1.
RefSeqiNP_056068.1. NM_015253.1.
XP_005256629.1. XM_005256572.1.
XP_005256630.1. XM_005256573.1.
XP_011522078.1. XM_011523776.1.
UniGeneiHs.370166.

Genome annotation databases

EnsembliENST00000317744; ENSP00000323087; ENSG00000179314.
ENST00000539421; ENSP00000446032; ENSG00000179314.
ENST00000574232; ENSP00000458374; ENSG00000179314.
ENST00000574946; ENSP00000460825; ENSG00000179314.
GeneIDi23302.
KEGGihsa:23302.
UCSCiuc002gcn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289603 mRNA. Translation: BAF82292.1.
AL833730 mRNA. Translation: CAH56249.1.
CH471108 Genomic DNA. Translation: EAW90316.1.
CH471108 Genomic DNA. Translation: EAW90317.1.
BC009975 mRNA. Translation: AAH09975.1.
AB011095 mRNA. Translation: BAA25449.1.
CCDSiCCDS32538.1.
RefSeqiNP_056068.1. NM_015253.1.
XP_005256629.1. XM_005256572.1.
XP_005256630.1. XM_005256573.1.
XP_011522078.1. XM_011523776.1.
UniGeneiHs.370166.

3D structure databases

ProteinModelPortaliQ658N2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ658N2.

Polymorphism and mutation databases

BioMutaiWSCD1.
DMDMi74724420.

Proteomic databases

PaxDbiQ658N2.
PRIDEiQ658N2.

Protocols and materials databases

DNASUi23302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317744; ENSP00000323087; ENSG00000179314.
ENST00000539421; ENSP00000446032; ENSG00000179314.
ENST00000574232; ENSP00000458374; ENSG00000179314.
ENST00000574946; ENSP00000460825; ENSG00000179314.
GeneIDi23302.
KEGGihsa:23302.
UCSCiuc002gcn.4. human.

Organism-specific databases

CTDi23302.
GeneCardsiWSCD1.
H-InvDBHIX0013475.
HGNCiHGNC:29060. WSCD1.
HPAiHPA015919.
neXtProtiNX_Q658N2.
PharmGKBiPA162409253.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR06. Eukaryota.
ENOG4111D3F. LUCA.
GeneTreeiENSGT00390000012250.
HOGENOMiHOG000060082.
HOVERGENiHBG102242.
InParanoidiQ658N2.
OMAiSKEWPDF.
OrthoDBiEOG7QZG95.
PhylomeDBiQ658N2.
TreeFamiTF324060.

Miscellaneous databases

ChiTaRSiWSCD1. human.
GenomeRNAii23302.
NextBioi45141.
PROiQ658N2.

Gene expression databases

BgeeiQ658N2.
CleanExiHS_WSCD1.
ExpressionAtlasiQ658N2. baseline and differential.
GenevisibleiQ658N2. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
IPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
PF01822. WSC. 2 hits.
[Graphical view]
SMARTiSM00321. WSC. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51212. WSC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-212.
    Tissue: Muscle.
  5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-575.
    Tissue: Brain.

Entry informationi

Entry nameiWSCD1_HUMAN
AccessioniPrimary (citable) accession number: Q658N2
Secondary accession number(s): A8K0N8
, D3DTM3, O60276, Q96G45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 25, 2004
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.