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Q658L1 (F154B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM154B
Gene names
Name:FAM154B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM154 family.

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q658L1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q658L1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAKSMRSWCLCQICSCG → MPW
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Protein FAM154B
PRO_0000321839

Natural variations

Alternative sequence1 – 1818MGAKS…ICSCG → MPW in isoform 2.
VSP_055086
Natural variant81S → G.
Corresponds to variant rs11631813 [ dbSNP | Ensembl ].
VAR_039359
Natural variant341P → L.
Corresponds to variant rs16973457 [ dbSNP | Ensembl ].
VAR_039360
Natural variant2251W → R.
Corresponds to variant rs11630197 [ dbSNP | Ensembl ].
VAR_039361

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 3A140F0C31B065C8

FASTA39845,933
        10         20         30         40         50         60 
MGAKSMRSWC LCQICSCGSD YCPYEIVKQP RHVPEEYKPK QGKIDLGTTY KRDLNSYKVQ 

        70         80         90        100        110        120 
PVAIVRPLER QVKKGKLDTV PTYKDDYRAW DLHKSELYKP EQTYHPPTVK FGNSTTFQDD 

       130        140        150        160        170        180 
FVPQEIKPRQ SFKPSSVVKR STAPFNGITS HRLDYIPHQL ELKFERPKEV YKPTDQRFED 

       190        200        210        220        230        240 
LTTHRCDFQG LIGETAKLCR PVHTRVTQNA LFEGSTEFRE SFQPWEIPPP EVKKVPEYVP 

       250        260        270        280        290        300 
PTGSMLLNST SHLDYVPYQA NHVVPIRPVS QKRSNNFPFQ GKSIMKEDFP AWESCRQGLI 

       310        320        330        340        350        360 
KKQQQIPNPS GKFDGLSTFR SHYVPHELIP TESCKPLNIA FKSSVPFDDV TMYSVEYTPK 

       370        380        390 
RQEICPASYP SPPGYIFDNT NSQGHKFFRK IIPAVKAF 

« Hide

Isoform 2 [UniParc].

Checksum: 6674FCB708CFE449
Show »

FASTA38344,402

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Trachea.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Stomach.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK304339 mRNA. Translation: BAG65184.1.
AL833762 mRNA. Translation: CAH56241.1.
AC026624 Genomic DNA. No translation available.
CCDSCCDS32310.1.
RefSeqNP_001008227.1. NM_001008226.1.
UniGeneHs.459117.

3D structure databases

ProteinModelPortalQ658L1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ658L1.

Polymorphism databases

DMDM74708419.

Proteomic databases

PaxDbQ658L1.
PRIDEQ658L1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339465; ENSP00000340445; ENSG00000188659.
ENST00000427381; ENSP00000403743; ENSG00000188659.
GeneID283726.
KEGGhsa:283726.
UCSCuc002bgv.3. human.

Organism-specific databases

CTD283726.
GeneCardsGC15P082555.
H-InvDBHIX0012504.
HGNCHGNC:33727. FAM154B.
HPAHPA040487.
HPA040833.
neXtProtNX_Q658L1.
PharmGKBPA162386665.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87688.
HOGENOMHOG000049249.
HOVERGENHBG060301.
InParanoidQ658L1.
OMAPWEIPPP.
PhylomeDBQ658L1.
TreeFamTF319394.

Gene expression databases

ArrayExpressQ658L1.
BgeeQ658L1.
CleanExHS_FAM154B.
GenevestigatorQ658L1.

Family and domain databases

InterProIPR024963. MAP6/FAM154.
[Graphical view]
PfamPF05217. STOP. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi283726.
NextBio94199.
PROQ658L1.

Entry information

Entry nameF154B_HUMAN
AccessionPrimary (citable) accession number: Q658L1
Secondary accession number(s): B4E2M2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 25, 2004
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM