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Q658L1

- F154B_HUMAN

UniProt

Q658L1 - F154B_HUMAN

Protein

Protein FAM154B

Gene

FAM154B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM154B
    Gene namesi
    Name:FAM154B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:33727. FAM154B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Protein FAM154BPRO_0000321839Add
    BLAST

    Proteomic databases

    PaxDbiQ658L1.
    PRIDEiQ658L1.

    PTM databases

    PhosphoSiteiQ658L1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ658L1.
    BgeeiQ658L1.
    CleanExiHS_FAM154B.
    GenevestigatoriQ658L1.

    Organism-specific databases

    HPAiHPA040487.
    HPA040833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ658L1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM154 family.Curated

    Phylogenomic databases

    eggNOGiNOG87688.
    HOGENOMiHOG000049249.
    HOVERGENiHBG060301.
    InParanoidiQ658L1.
    OMAiPWEIPPP.
    PhylomeDBiQ658L1.
    TreeFamiTF319394.

    Family and domain databases

    InterProiIPR024963. MAP6/FAM154.
    [Graphical view]
    PfamiPF05217. STOP. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q658L1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAKSMRSWC LCQICSCGSD YCPYEIVKQP RHVPEEYKPK QGKIDLGTTY    50
    KRDLNSYKVQ PVAIVRPLER QVKKGKLDTV PTYKDDYRAW DLHKSELYKP 100
    EQTYHPPTVK FGNSTTFQDD FVPQEIKPRQ SFKPSSVVKR STAPFNGITS 150
    HRLDYIPHQL ELKFERPKEV YKPTDQRFED LTTHRCDFQG LIGETAKLCR 200
    PVHTRVTQNA LFEGSTEFRE SFQPWEIPPP EVKKVPEYVP PTGSMLLNST 250
    SHLDYVPYQA NHVVPIRPVS QKRSNNFPFQ GKSIMKEDFP AWESCRQGLI 300
    KKQQQIPNPS GKFDGLSTFR SHYVPHELIP TESCKPLNIA FKSSVPFDDV 350
    TMYSVEYTPK RQEICPASYP SPPGYIFDNT NSQGHKFFRK IIPAVKAF 398
    Length:398
    Mass (Da):45,933
    Last modified:October 25, 2004 - v1
    Checksum:i3A140F0C31B065C8
    GO
    Isoform 2 (identifier: Q658L1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MGAKSMRSWCLCQICSCG → MPW

    Note: No experimental confirmation available.

    Show »
    Length:383
    Mass (Da):44,402
    Checksum:i6674FCB708CFE449
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81S → G.
    Corresponds to variant rs11631813 [ dbSNP | Ensembl ].
    VAR_039359
    Natural varianti34 – 341P → L.
    Corresponds to variant rs16973457 [ dbSNP | Ensembl ].
    VAR_039360
    Natural varianti225 – 2251W → R.
    Corresponds to variant rs11630197 [ dbSNP | Ensembl ].
    VAR_039361

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818MGAKS…ICSCG → MPW in isoform 2. 1 PublicationVSP_055086Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304339 mRNA. Translation: BAG65184.1.
    AL833762 mRNA. Translation: CAH56241.1.
    AC026624 Genomic DNA. No translation available.
    CCDSiCCDS32310.1. [Q658L1-1]
    RefSeqiNP_001008227.1. NM_001008226.1.
    XP_005254376.1. XM_005254319.2.
    XP_006720539.1. XM_006720476.1.
    UniGeneiHs.459117.

    Genome annotation databases

    EnsembliENST00000339465; ENSP00000340445; ENSG00000188659. [Q658L1-1]
    GeneIDi283726.
    KEGGihsa:283726.
    UCSCiuc002bgv.3. human. [Q658L1-1]

    Polymorphism databases

    DMDMi74708419.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304339 mRNA. Translation: BAG65184.1 .
    AL833762 mRNA. Translation: CAH56241.1 .
    AC026624 Genomic DNA. No translation available.
    CCDSi CCDS32310.1. [Q658L1-1 ]
    RefSeqi NP_001008227.1. NM_001008226.1.
    XP_005254376.1. XM_005254319.2.
    XP_006720539.1. XM_006720476.1.
    UniGenei Hs.459117.

    3D structure databases

    ProteinModelPortali Q658L1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q658L1.

    Polymorphism databases

    DMDMi 74708419.

    Proteomic databases

    PaxDbi Q658L1.
    PRIDEi Q658L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339465 ; ENSP00000340445 ; ENSG00000188659 . [Q658L1-1 ]
    GeneIDi 283726.
    KEGGi hsa:283726.
    UCSCi uc002bgv.3. human. [Q658L1-1 ]

    Organism-specific databases

    CTDi 283726.
    GeneCardsi GC15P082555.
    H-InvDB HIX0012504.
    HGNCi HGNC:33727. FAM154B.
    HPAi HPA040487.
    HPA040833.
    neXtProti NX_Q658L1.
    PharmGKBi PA162386665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87688.
    HOGENOMi HOG000049249.
    HOVERGENi HBG060301.
    InParanoidi Q658L1.
    OMAi PWEIPPP.
    PhylomeDBi Q658L1.
    TreeFami TF319394.

    Miscellaneous databases

    GenomeRNAii 283726.
    NextBioi 35477317.
    PROi Q658L1.

    Gene expression databases

    ArrayExpressi Q658L1.
    Bgeei Q658L1.
    CleanExi HS_FAM154B.
    Genevestigatori Q658L1.

    Family and domain databases

    InterProi IPR024963. MAP6/FAM154.
    [Graphical view ]
    Pfami PF05217. STOP. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Stomach.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiF154B_HUMAN
    AccessioniPrimary (citable) accession number: Q658L1
    Secondary accession number(s): B4E2M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3