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Protein

Stabilizer of axonemal microtubules 2

Gene

SAXO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Stabilizer of axonemal microtubules 2
Gene namesi
Name:SAXO2
Synonyms:FAM154B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000188659.9.
HGNCiHGNC:33727. SAXO2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188659.
PharmGKBiPA162386665.

Polymorphism and mutation databases

BioMutaiFAM154B.
DMDMi74708419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218391 – 398Stabilizer of axonemal microtubules 2Add BLAST398

Proteomic databases

PaxDbiQ658L1.
PeptideAtlasiQ658L1.
PRIDEiQ658L1.

PTM databases

iPTMnetiQ658L1.
PhosphoSitePlusiQ658L1.

Expressioni

Gene expression databases

BgeeiENSG00000188659.
CleanExiHS_FAM154B.
ExpressionAtlasiQ658L1. baseline and differential.
GenevisibleiQ658L1. HS.

Organism-specific databases

HPAiHPA040487.
HPA040833.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ658L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM154 family.Curated

Phylogenomic databases

eggNOGiENOG410IFF0. Eukaryota.
ENOG410Z4HD. LUCA.
GeneTreeiENSGT00390000007252.
HOGENOMiHOG000049249.
HOVERGENiHBG060301.
InParanoidiQ658L1.
OMAiPWEIPPP.
OrthoDBiEOG091G0GMK.
PhylomeDBiQ658L1.
TreeFamiTF319394.

Family and domain databases

InterProiView protein in InterPro
IPR033336. SAXO1/2.
PANTHERiPTHR31516. PTHR31516. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q658L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAKSMRSWC LCQICSCGSD YCPYEIVKQP RHVPEEYKPK QGKIDLGTTY
60 70 80 90 100
KRDLNSYKVQ PVAIVRPLER QVKKGKLDTV PTYKDDYRAW DLHKSELYKP
110 120 130 140 150
EQTYHPPTVK FGNSTTFQDD FVPQEIKPRQ SFKPSSVVKR STAPFNGITS
160 170 180 190 200
HRLDYIPHQL ELKFERPKEV YKPTDQRFED LTTHRCDFQG LIGETAKLCR
210 220 230 240 250
PVHTRVTQNA LFEGSTEFRE SFQPWEIPPP EVKKVPEYVP PTGSMLLNST
260 270 280 290 300
SHLDYVPYQA NHVVPIRPVS QKRSNNFPFQ GKSIMKEDFP AWESCRQGLI
310 320 330 340 350
KKQQQIPNPS GKFDGLSTFR SHYVPHELIP TESCKPLNIA FKSSVPFDDV
360 370 380 390
TMYSVEYTPK RQEICPASYP SPPGYIFDNT NSQGHKFFRK IIPAVKAF
Length:398
Mass (Da):45,933
Last modified:October 25, 2004 - v1
Checksum:i3A140F0C31B065C8
GO
Isoform 2 (identifier: Q658L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAKSMRSWCLCQICSCG → MPW

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):44,402
Checksum:i6674FCB708CFE449
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0393598S → G. Corresponds to variant dbSNP:rs11631813Ensembl.1
Natural variantiVAR_03936034P → L. Corresponds to variant dbSNP:rs16973457Ensembl.1
Natural variantiVAR_039361225W → R. Corresponds to variant dbSNP:rs11630197Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550861 – 18MGAKS…ICSCG → MPW in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304339 mRNA. Translation: BAG65184.1.
AL833762 mRNA. Translation: CAH56241.1.
AC026624 Genomic DNA. No translation available.
CCDSiCCDS32310.1. [Q658L1-1]
RefSeqiNP_001008227.1. NM_001008226.1. [Q658L1-1]
NP_001335631.1. NM_001348702.1. [Q658L1-2]
NP_001335632.1. NM_001348703.1. [Q658L1-2]
UniGeneiHs.459117.

Genome annotation databases

EnsembliENST00000339465; ENSP00000340445; ENSG00000188659. [Q658L1-1]
GeneIDi283726.
KEGGihsa:283726.
UCSCiuc002bgv.4. human. [Q658L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAXO2_HUMAN
AccessioniPrimary (citable) accession number: Q658L1
Secondary accession number(s): B4E2M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 25, 2004
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families