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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NSP1UniRule annotation
Alternative name(s):
NCVP2UniRule annotation
Non-structural RNA-binding protein 53UniRule annotation
Short name:
NS53UniRule annotation
OrganismiRotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
Taxonomic identifieri1835656 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

  • host cytoskeleton UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003690691 – 491Non-structural protein 1Add BLAST491

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.UniRule annotation

Structurei

3D structure databases

SMRiQ65709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 81RNA-bindingUniRule annotationAdd BLAST81
Regioni42 – 79Zinc-binding domainUniRule annotationAdd BLAST38
Regioni82 – 176Important for cytoskeleton localizationUniRule annotationAdd BLAST95
Regioni320 – 491Interaction with host IRF3UniRule annotationAdd BLAST172

Domaini

The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.UniRule annotation

Sequence similaritiesi

Belongs to the rotavirus NSP1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04088 ROTA_NSP1, 1 hit
InterProiView protein in InterPro
IPR002148 Rotavirus_NSP1
PfamiView protein in Pfam
PF00981 Rota_NS53, 1 hit

Sequencei

Sequence statusi: Complete.

Q65709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFKDACYH YKKLNKLNGL VLKLGANDAW RPAPVAKYKG WCLDCCQHTD
60 70 80 90 100
LTYCRGCALF HVCQWCSRYN RCFLDEEPHL LRMRTFRNEI NKEDVEGLIN
110 120 130 140 150
MYNIIFPINE RVVDKFINNV KQRKCRNELL IEWYNHLLLP ITLQALSIEL
160 170 180 190 200
EGDVYYIFGY YDCMGKENQT PFHFVNMINR YDRLLLDDKN FDRMMHLPVA
210 220 230 240 250
LQQEYALRYF SKSRFISQIK REMNRHDFSD NLMEERDNPM SFMQVTRNCV
260 270 280 290 300
SAHMNDNDWN ERCKLIGDAR NYMELMKSAY TEHYSISNRC KLFTIYKLNI
310 320 330 340 350
ISKLVKPNYI FSNHGLCALD VNNCKWCKID NHYEIWNDFR LRKIYNNMMN
360 370 380 390 400
FIRALVKSNT NVGHCSSHEL VYKCISSVFI VWKIEKWNDS VRTLFEYLEP
410 420 430 440 450
VEINHVEYVL LDHELSWEMS GVIMQIMNGK VPRILSFDDV KKIMGAIIYD
460 470 480 490
WFDVRYMRET PVIVSTTNEL RKLNKDNNLM DGYDYELSDI E
Length:491
Mass (Da):58,748
Last modified:November 1, 1996 - v1
Checksum:i4E6FBCF4466484FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12105 Genomic RNA Translation: CAA78090.1
PIRiS31784

Similar proteinsi

Entry informationi

Entry nameiNSP1_ROTBB
AccessioniPrimary (citable) accession number: Q65709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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