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Q65527

- VP7_ROTBS

UniProt

Q65527 - VP7_ROTBS

Protein

Outer capsid glycoprotein VP7

Gene
N/A
Organism
Rotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.By similarity

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer capsid glycoprotein VP7
    OrganismiRotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
    Taxonomic identifieri33723 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    Subcellular locationi

    Virion By similarity. Host endoplasmic reticulum lumen Curated
    Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. T=13 icosahedral viral capsid Source: UniProtKB-KW
    3. viral outer capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host endoplasmic reticulum, Outer capsid protein, T=13 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4949Sequence AnalysisAdd
    BLAST
    Chaini50 – 332283Outer capsid glycoprotein VP7PRO_0000369879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi270 – 2701N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity
    Intramolecular disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP7 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001963. VP7.
    [Graphical view]
    PfamiPF00434. VP7. 1 hit.
    [Graphical view]
    ProDomiPD000191. VP7. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q65527-1 [UniParc]FASTAAdd to Basket

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    MVCTTLYTVC VILCILLMYI ILFRKMIHFL IDLSLIAFVI SSCIRLSNAQ    50
    FFANDMLYNG NVEGVINTTN IFNVESLCIY FPNSAVGRPG PGKSDGLIND 100
    NNYAQTLAVL FETKGFPKGS VNFNTYTKIS DFINSIEMTC SYNIVIIPET 150
    LANSETIEQV AEWVLNVWKC DNMNVDIYTY EQIGKDNFWA AFGEDCDVAV 200
    CPLDTTMNGI GCTPASTETY EVLSNDTQLA LIDVVDNVKH RIQLNQVTCK 250
    LRNCVKGEAR LNTAIVRISN LSSFDNSLSP LNNGQKTRSF KINAKKWWKI 300
    FYTIIDYINT FIQSMTPRHR AIYPEGWMLR YA 332
    Length:332
    Mass (Da):37,590
    Last modified:November 1, 1996 - v1
    Checksum:i72C4F211ADA93FBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31750 Genomic RNA. Translation: AAC55011.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31750 Genomic RNA. Translation: AAC55011.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001963. VP7.
    [Graphical view ]
    Pfami PF00434. VP7. 1 hit.
    [Graphical view ]
    ProDomi PD000191. VP7. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence comparison of the VP7 gene encoding the outer capsid glycoprotein among animal and human group C rotaviruses."
      Tsunemitsu H., Jiang B., Saif L.J.
      Arch. Virol. 141:705-713(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP7_ROTBS
    AccessioniPrimary (citable) accession number: Q65527
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3