Q65387 (MVP_BBTVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Movement and RNA silencing protein
Short name=MP

Gene names

Name:	DNA-M
Synonyms:	C4

Organism

Banana bunchy top virus (isolate Autralia) (BBTV) [Reference proteome]

Taxonomic identifier

645099 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Nanoviridae › Babuvirus › Banana bunchy top virus

Virus host

Musa [TaxID: 4640]

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Begomovirus genome is shuttled out of nucleus by Nuclear shuttle protein (NSP) and the movement protein transports the DNA-NSP complex to cell plasmodesmata and facilitates further movement across the cell wall. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Ref.3

Subcellular location

Host cell membrane; Single-pass membrane protein Potential. Note: The hydrophobic region is responsible for the localization of the protein to the cell periphery. Ref.2

Ontologies

Keywords
Biological process	Transport
Cellular component	Host cell membrane Host membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Suppressor of RNA silencing Viral movement protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	spread of virus in host, cell to cell Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Movement and RNA silencing protein		PRO_0000378541
Regions
	Transmembrane	15 – 35	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q65387 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EE1EA08FC63590A7	FASTA	117	13,739
	10 20 30 40 50 60 MALTTERVKL FFEWFLFFGA IFIAITILYI LLVLLFEVPR YIKELVRCLV EYLTRRRVWM 70 80 90 100 110 QRTQLTEATG DVEIGRGIVE DRRDQEPAVI PHVSQVIPSQ PNRRDDQGRR GNAGPMF

References

[1]	"The genome organization of banana bunchy top virus: analysis of six ssDNA components." Burns T.M., Harding R.M., Dale J.L. J. Gen. Virol. 76:1471-1482(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Functional analysis of proteins encoded by banana bunchy top virus DNA-4 to -6." Wanitchakorn R., Hafner G.J., Harding R.M., Dale J.L. J. Gen. Virol. 81:299-306(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[3]	"Identification of two RNA silencing suppressors from banana bunchy top virus." Niu S., Wang B., Guo X., Yu J., Wang X., Xu K., Zhai Y., Wang J., Liu Z. Arch. Virol. 154:1775-1783(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41575 Genomic DNA. Translation: AAA87369.1.
RefSeq	NP_604478.1. NC_003474.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	963868.
Family and domain databases
InterPro	IPR009871. BBTV_Orf1. [Graphical view]
Pfam	PF07234. DUF1426. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MVP_BBTVA

Accession

Primary (citable) accession number: Q65387

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program