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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

Ba71V-131

Organism
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The viral dUTPase may play a role in lowering the dUTP concentration in natural infections to minimize misincorporation of deoxyuridine into the viral DNA and ensure the fidelity of genome replication.

Miscellaneous

Expressed early and late in the infection.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+Curated

Kineticsi

  1. KM=1 µM for dUTP

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism
    LigandMagnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Ordered Locus Names:Ba71V-131
    ORF Names:E165R
    OrganismiAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
    Taxonomic identifieri10498 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
    Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
    Sus scrofa (Pig) [TaxID: 9823]
    Proteomesi
    • UP000000624 Componenti: Genome

    Subcellular locationi

    Q65199:
    • Host cytoplasm 1 Publication

    GO - Cellular componenti

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003731331 – 165Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST165

    Interactioni

    Subunit structurei

    Homotrimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65199.
    SMRiQ65199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Phylogenomic databases

    OrthoDBiVOG090000V4.

    Family and domain databases

    CDDicd07557. trimeric_dUTPase. 1 hit.
    InterProiView protein in InterPro
    IPR029054. dUTPase-like.
    IPR036157. dUTPase-like_sf.
    IPR033704. dUTPase_trimeric.
    PfamiView protein in Pfam
    PF00692. dUTPase. 1 hit.
    SUPFAMiSSF51283. SSF51283. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65199-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MATNFFIQPI TQEAEAYYPP SVITNKRKDL GVDVYCCSDL VLQPGLNIVR
    60 70 80 90 100
    LHIKVACEHM GKKCGFKIMA RSSMCTHERL LILANGIGLI DPGYVGELML
    110 120 130 140 150
    KIINLGDTPV QIWAKECLVQ LVAQGDHVPD HINILKRNQI FPLFAPTPRG
    160
    EGRFGSTGEA GIMRT
    Length:165
    Mass (Da):18,262
    Last modified:November 1, 1996 - v1
    Checksum:i06633952CDC927E5
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U18466 Genomic DNA. Translation: AAA65359.1.
    RefSeqiNP_042823.1. NC_001659.2.

    Genome annotation databases

    GeneIDi22220359.
    KEGGivg:22220359.

    Similar proteinsi

    Entry informationi

    Entry nameiDUTP_ASFB7
    AccessioniPrimary (citable) accession number: Q65199
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: November 1, 1996
    Last modified: October 25, 2017
    This is version 82 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families