SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q65199

- DUTP_ASFB7

UniProt

Q65199 - DUTP_ASFB7

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
Ba71V-131, E165R
Organism
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The viral dUTPase may play a role in lowering the dUTP concentration in natural infections to minimize misincorporation of deoxyuridine into the viral DNA and ensure the fidelity of genome replication.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium Inferred.

Kineticsi

  1. KM=1 µM for dUTP

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Ordered Locus Names:Ba71V-131
ORF Names:E165R
OrganismiAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Taxonomic identifieri10498 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000000624: Genome

Subcellular locationi

Host cytoplasm 1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000373133Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliQ65199.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65199-1 [UniParc]FASTAAdd to Basket

« Hide

MATNFFIQPI TQEAEAYYPP SVITNKRKDL GVDVYCCSDL VLQPGLNIVR    50
LHIKVACEHM GKKCGFKIMA RSSMCTHERL LILANGIGLI DPGYVGELML 100
KIINLGDTPV QIWAKECLVQ LVAQGDHVPD HINILKRNQI FPLFAPTPRG 150
EGRFGSTGEA GIMRT 165
Length:165
Mass (Da):18,262
Last modified:November 1, 1996 - v1
Checksum:i06633952CDC927E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18466 Genomic DNA. Translation: AAA65359.1.
RefSeqiNP_042823.1. NC_001659.1.

Genome annotation databases

GeneIDi1488894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18466 Genomic DNA. Translation: AAA65359.1 .
RefSeqi NP_042823.1. NC_001659.1.

3D structure databases

ProteinModelPortali Q65199.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1488894.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the complete nucleotide sequence of African swine fever virus."
    Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.
    Virology 208:249-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages."
    Oliveros M., Garcia-Escudero R., Alejo A., Vinuela E., Salas M.L., Salas J.
    J. Virol. 73:8934-8943(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDUTP_ASFB7
AccessioniPrimary (citable) accession number: Q65199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Expressed early and late in the infection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi