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Q65163 (FLSO_ASFB7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAD-linked sulfhydryl oxidase

EC=1.8.3.2
Alternative name(s):
p14
Gene names
Ordered Locus Names:Ba71V-073
ORF Names:9GL, B119L
OrganismAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) [Reference proteome]
Taxonomic identifier10498 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity. Involved in virion maturation. Ref.3

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

FAD By similarity.

Subunit structure

Interacts with A151R. Ref.3

Subcellular location

Host cytoplasm Ref.3.

Induction

Expressed late in the infection cycle.

Sequence similarities

Belongs to the asfivirus B119L family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentHost cytoplasm
   Developmental stageLate protein
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthiol oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119FAD-linked sulfhydryl oxidase
PRO_0000208551

Regions

Domain1 – 9797ERV/ALR sulfhydryl oxidase

Amino acid modifications

Disulfide bond44 ↔ 47Redox-active Potential

Secondary structure

........... 119
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q65163 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A1EE2F073ABF9726

FASTA11914,378
        10         20         30         40         50         60 
MLHWGPKYWR SLHLYAIFFS DAPSWKEKYE AIQWILNFIE SLPCTRCQHH AFSYLTKNPL 

        70         80         90        100        110 
TLNNSEDFQY WTFAFHNNVN NRLNKKIISW SEYKNIYEQS ILKTIEYGKT DFIGAWSSL 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the complete nucleotide sequence of African swine fever virus."
Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.
Virology 208:249-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine."
Lewis T., Zsak L., Burrage T.G., Lu Z., Kutish G.F., Neilan J.G., Rock D.L.
J. Virol. 74:1275-1285(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[3]"African swine fever virus pB119L protein is a flavin adenine dinucleotide-linked sulfhydryl oxidase."
Rodriguez I., Redrejo-Rodriguez M., Rodriguez J.M., Alejo A., Salas J., Salas M.L.
J. Virol. 80:3157-3166(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH A151R.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18466 Genomic DNA. Translation: AAA65303.1.
RefSeqNP_042767.1. NC_001659.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3GWLX-ray2.10A/B1-103[»]
ProteinModelPortalQ65163.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488838.

Family and domain databases

Gene3D1.20.120.310. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
[Graphical view]
SUPFAMSSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ65163.

Entry information

Entry nameFLSO_ASFB7
AccessionPrimary (citable) accession number: Q65163
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 22, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references