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Q650J1 (Q650J1_BACFR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:BF0084 EMBL BAD46833.1
OrganismBacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP] EMBL BAD46833.1
Taxonomic identifier295405 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain111 – 318208ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding139 – 19961ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2881Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2901Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
Q650J1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: C017A5E8485F0018

FASTA42445,727
        10         20         30         40         50         60 
MKILLLGSGG REHALAWKIA QSPKVEKLFI APGNAGTGEV GENVNIKATD FAALGAFALE 

        70         80         90        100        110        120 
ESIDMIVVGP EDPLVEGIYD HFQSNPCLKN IAIIGPSKEG ARLEGSKEFA KEFMHRHHIP 

       130        140        150        160        170        180 
TARYQSVTAD TLNEGLAFLE TLEAPYVLKA DGLCAGKGVL ILPTLEEAKK ELKEMLGGMF 

       190        200        210        220        230        240 
GNASATVVIE EFLSGIECSV FVLTDGDHYK VLPVAKDYKR IGEGDKGLNT GGMGSVTPVP 

       250        260        270        280        290        300 
FADEVFMEKV RTRIIEPTVN GLKAEGITYK GFIFLGLINV KGEPMVIEYN VRMGDPETES 

       310        320        330        340        350        360 
VMLRIQSDLV ELLEGVAEGN LDARSLVIDP RTATCVMMVS GGYPEAYQKG YAINGLEAAR 

       370        380        390        400        410        420 
ATDSILFHAG TAMKDGQAVT SGGRVLAICS YGNDKADALA QCYKVADMID FKDKNYRRDI 


GFDL

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References

[1]"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YCH46 EMBL BAD46833.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006841 Genomic DNA. Translation: BAD46833.1.
RefSeqYP_097367.1. NC_006347.1.

3D structure databases

ProteinModelPortalQ650J1.
ModBaseSearch...

Protein-protein interaction databases

STRING295405.BF0084.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD46833; BAD46833; BF0084.
GeneID3081416.
KEGGbfr:BF0084.
PATRIC21045974. VBIBacFra17906_0122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01945.
OMAMGAYTPL.
ProtClustDBPRK00885.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ650J1_BACFR
AccessionPrimary (citable) accession number: Q650J1
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info