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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei178FADUniRule annotation1
Binding sitei368FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16FADUniRule annotation6
Nucleotide bindingi271 – 285NADUniRule annotationAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:BF0100
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170561 – 625tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST625

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ650H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q650H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKYDVIVI GAGHAGCEAA AAAANLGSKT CLITMDMNKV AQMSCNPAVG
60 70 80 90 100
GIAKGQIVRE IDALGGYMGL VTDQTAIQFR ILNRSKGPAM WSPRAQCDRN
110 120 130 140 150
KFIWAWREIL ENIPNLHIWQ DTVKEIIVEN GEVVGLKTFW DVTFHARCIV
160 170 180 190 200
LTAGTFLNGL MHVGKTQLPG GRMAEPASYK LTESIAKHGI EYGRMKTGTP
210 220 230 240 250
VRIDGRSVHY ELMDTQDGEC DFHKFSFMNT SVRHLKQLQC WTCFTNEEAH
260 270 280 290 300
NVLRNGLADS PLFNGQIQSI GPRYCPSIET KIVTFPDKEQ HQLFLEPEGE
310 320 330 340 350
TTQELYLNGF SSSLPMEIQI EALKKIPAFK DLVIYRPGYA IEYDYFDPTQ
360 370 380 390 400
LKHTLESKKI KNLFFAGQVN GTTGYEEAGG QGIIAGINAH INCHGGEPFT
410 420 430 440 450
LARDEAYIGV LIDDLVTKGV DEPYRMFTSR AEYRILLRMD DADMRLTERA
460 470 480 490 500
YKLGLVKEDR YALLKSKREA VENIVNFTRN YSIKAALIND ALENLGTTPL
510 520 530 540 550
RQGCKLIDLI NRPQITIENI SEYVPAFKRE LDKITDERKE EILEAAEILI
560 570 580 590 600
KYEGYIGRER IIADKLARLE SIKIKGKFDY DSLQSLSTEA RQKLKKIDPE
610 620
TIAQASRIPG VSPSDINVLL VLSGR
Length:625
Mass (Da):70,191
Last modified:October 25, 2004 - v1
Checksum:i9636E088B6C5E34F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD46849.1.
RefSeqiWP_005783704.1. NC_006347.1.
YP_097383.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD46849; BAD46849; BF0100.
GeneIDi3082087.
KEGGibfr:BF0100.
PATRICi21046006. VBIBacFra17906_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD46849.1.
RefSeqiWP_005783704.1. NC_006347.1.
YP_097383.1. NC_006347.1.

3D structure databases

ProteinModelPortaliQ650H5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD46849; BAD46849; BF0100.
GeneIDi3082087.
KEGGibfr:BF0100.
PATRICi21046006. VBIBacFra17906_0138.

Phylogenomic databases

HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiPOG091H01O0.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNMG_BACFR
AccessioniPrimary (citable) accession number: Q650H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.