Reviewed, UniProtKB/Swiss-Prot Q650A0 (UXUA_BACFR)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	BF0177

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Mannonate dehydratase HAMAP MF_00106		PRO_0000231050

Sequences

	Sequence		Length	Mass (Da)
	Q650A0-1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 62667B3582CE084F	FASTA	396	45,357
	10 20 30 40 50 60 MTLLKDKLFL SEQTWRWYGP DDPVSLWDIK QAGATGIVNA LHHIPNGEVW TVEEIMKRKE 70 80 90 100 110 120 LIESVGLKWS VVESVPVHEH IKTQTGNFRK YIENYKESLR NLGQCGIHIV TYNFMPVLDW 130 140 150 160 170 180 TRTDLAYTLP DGSKALRFER AAFIAFDLFL LKRPGAETEY TDEEKTKARI RFEQMDEKEK 190 200 210 220 230 240 QLLVRNMIAG LPGSEESFTL EQFQHELDRY RGIDAEKLRT HLIYFLKEIT STADEAGVKL 250 260 270 280 290 300 VIHPDDPPCS ILGLPRIMSC AEDFQALIDA VPNESNGLCL CTGSLGVSCA NDLEGMMRRF 310 320 330 340 350 360 GDRINFVHFR STQRDAEGNF YEANHLEGDV DMYHVMKAFL ELQQRRKVSI PMRPDHGHQM 370 380 390 VDDLKKKTNP GYSCIGRLRG LAELRGLEMG IAKSIF

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD46926.1. Different initiation.
RefSeq	YP_097460.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3081718.
GenomeReviews	Gene locus BF0177 in contig AP006841_GR.
KEGG	bfr:BF0177.
NMPDR	fig|295405.3.peg.310.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q650A0.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0177-MON.
BRENDA	4.2.1.8. 868.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACFR

Accession

Primary (citable) accession number: Q650A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 20, 2009
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)