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Q64ZT8

- SPEA_BACFR

UniProt

Q64ZT8 - SPEA_BACFR

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:BF0239
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Biosynthetic arginine decarboxylasePRO_1000024255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi295405.BF0239.

Structurei

3D structure databases

ProteinModelPortaliQ64ZT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 29111Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0019.
KOiK01585.
OMAiKPLYIGF.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64ZT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKWRIEDSE ELYNITGWGT SYFGINDKGH VVVTPRKDGV AVDLKELVDE
60 70 80 90 100
LQLRDVAAPM LVRFPDILDN RIEKTAYCFK QASEEYGYKA QNFIIYPIKV
110 120 130 140 150
NQMRPVVEEI ISHGKKFNLG LEAGSKPELH AVIAVNTDSD SLIICNGYKD
160 170 180 190 200
ESYIELALLA QKMGKRIFLV VEKMNELKLI ARMAKQLNVQ PNIGIRIKLA
210 220 230 240 250
SSGSGKWEES GGDASKFGLT SSELLEALDF LESKGMKDCL KLIHFHIGSQ
260 270 280 290 300
VTKIRRIKTA LREASQFYVQ LHAMGFNVEF VDIGGGLGVD YDGTRSSSSE
310 320 330 340 350
SSVNYSIQEY VNDSISTLVD ASDKNGIPHP NIITESGRAL TAHHSVLIFE
360 370 380 390 400
VLETATLPQW DDEEEIAPDA HELVQELYGI WDTLNQNKML EAWHDAQQIR
410 420 430 440 450
EEALDLFSHG IVDLKTRAQI ERLYWSITRE INQIAGGLKH APDEFRGLSK
460 470 480 490 500
LLADKYFCNF SLFQSLPDSW AIDQIFPIMP IQRLDEKPDR SATLQDITCD
510 520 530 540 550
SDGKIANFIS TRNVAHYMPV HSLKQKEPYY VAVFLVGAYQ EILGDMHNLF
560 570 580 590 600
GDTNAVHVSV NEKGYNIEQI IDGETVAEVL DYVQYSPKKL VRTLETWVTK
610 620 630
SVKEGKISVE EGKEFLSNYR SGLYGYTYLE
Length:630
Mass (Da):71,190
Last modified:October 25, 2004 - v1
Checksum:i9A266E486AED6C19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD46988.1.
RefSeqiYP_097522.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD46988; BAD46988; BF0239.
GeneIDi3081620.
KEGGibfr:BF0239.
PATRICi21046268. VBIBacFra17906_0269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006841 Genomic DNA. Translation: BAD46988.1 .
RefSeqi YP_097522.1. NC_006347.1.

3D structure databases

ProteinModelPortali Q64ZT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295405.BF0239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD46988 ; BAD46988 ; BF0239 .
GeneIDi 3081620.
KEGGi bfr:BF0239.
PATRICi 21046268. VBIBacFra17906_0269.

Phylogenomic databases

eggNOGi COG0019.
KOi K01585.
OMAi KPLYIGF.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46.

Entry informationi

Entry nameiSPEA_BACFR
AccessioniPrimary (citable) accession number: Q64ZT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3