Reviewed, UniProtKB/Swiss-Prot Q64ZT8 (SPEA_BACFR)

Names and origin

Protein names

Recommended name:
    Biosynthetic arginine decarboxylase
      Short name=ADC
    EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	BF0239

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_1000024255
Regions
	Region	281 – 291	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	99	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64ZT8-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 9A266E486AED6C19	FASTA	630	71,190
	10 20 30 40 50 60 MRKWRIEDSE ELYNITGWGT SYFGINDKGH VVVTPRKDGV AVDLKELVDE LQLRDVAAPM 70 80 90 100 110 120 LVRFPDILDN RIEKTAYCFK QASEEYGYKA QNFIIYPIKV NQMRPVVEEI ISHGKKFNLG 130 140 150 160 170 180 LEAGSKPELH AVIAVNTDSD SLIICNGYKD ESYIELALLA QKMGKRIFLV VEKMNELKLI 190 200 210 220 230 240 ARMAKQLNVQ PNIGIRIKLA SSGSGKWEES GGDASKFGLT SSELLEALDF LESKGMKDCL 250 260 270 280 290 300 KLIHFHIGSQ VTKIRRIKTA LREASQFYVQ LHAMGFNVEF VDIGGGLGVD YDGTRSSSSE 310 320 330 340 350 360 SSVNYSIQEY VNDSISTLVD ASDKNGIPHP NIITESGRAL TAHHSVLIFE VLETATLPQW 370 380 390 400 410 420 DDEEEIAPDA HELVQELYGI WDTLNQNKML EAWHDAQQIR EEALDLFSHG IVDLKTRAQI 430 440 450 460 470 480 ERLYWSITRE INQIAGGLKH APDEFRGLSK LLADKYFCNF SLFQSLPDSW AIDQIFPIMP 490 500 510 520 530 540 IQRLDEKPDR SATLQDITCD SDGKIANFIS TRNVAHYMPV HSLKQKEPYY VAVFLVGAYQ 550 560 570 580 590 600 EILGDMHNLF GDTNAVHVSV NEKGYNIEQI IDGETVAEVL DYVQYSPKKL VRTLETWVTK 610 620 630 SVKEGKISVE EGKEFLSNYR SGLYGYTYLE

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD46988.1.
RefSeq	YP_097522.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3081620.
GenomeReviews	Gene locus BF0239 in contig AP006841_GR.
KEGG	bfr:BF0239.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q64ZT8.
OMA	LICNGYK.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0239-MON.
BRENDA	4.1.1.19. 868.
Family and domain databases
HAMAP	MF_01417. [Tree]
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_BACFR

Accession

Primary (citable) accession number: Q64ZT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)