Q64ZT7 (ARGB_BACFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BF0240

Organism

Bacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]

Taxonomic identifier

295405 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112581
Regions
	Region	45 – 46	2	Substrate binding By similarity
Sites
	Binding site	67	1	Substrate By similarity
	Binding site	162	1	Substrate By similarity
	Site	13	1	Transition state stabilizer By similarity
	Site	228	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64ZT7 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: DEEE56EAC5A7DB9D	FASTA	261	27,994
	10 20 30 40 50 60 MKEKMKEKLT VIKVGGKIVE EEATLNQLLN DFAAIEGHKV LVHGGGRSAT KIAAQLGIDS 70 80 90 100 110 120 KMVNGRRITD AETLKVVTMV YGGLVNKNIV AGLQARGVNA LGLTGADMNV IRSMKRPVKE 130 140 150 160 170 180 VDYGFVGDVE RVDSTLLSDL IHKGVVPVMA PLTHDGQGNM LNTNADTIAG ETAKALSAIF 190 200 210 220 230 240 DVTLVYCFEK KGVLRDENDD ESVIPQINHA EFQRYIAEGV IQGGMIPKLE NSFEAINAGV 250 260 SEVVITLASA IHTDGGTRIK K

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006841 Genomic DNA. Translation: BAD46989.1.
RefSeq	YP_097523.1. NC_006347.1.
3D structure databases
ProteinModelPortal	Q64ZT7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3082382.
GenomeReviews	Gene locus BF0240 in contig AP006841_GR.
KEGG	bfr:BF0240.
PATRIC	21046270. VBIBacFra17906_0270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGCLVDD.
PhylomeDB	Q64ZT7.
ProtClustDB	CLSK913611.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0240-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACFR

Accession

Primary (citable) accession number: Q64ZT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program