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Q64ZS4

- FUCI_BACFR

UniProt

Q64ZS4 - FUCI_BACFR

Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei337 – 3371Proton acceptorUniRule annotation
    Metal bindingi337 – 3371ManganeseUniRule annotation
    Active sitei361 – 3611Proton acceptorUniRule annotation
    Metal bindingi361 – 3611ManganeseUniRule annotation
    Metal bindingi528 – 5281ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:BF0253
    OrganismiBacteroides fragilis (strain YCH46)
    Taxonomic identifieri295405 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002197: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590L-fucose isomerasePRO_0000204142Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi295405.BF0253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64ZS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000256031.
    KOiK01818.
    OMAiFWEISDE.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q64ZS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKYPKIGIR PTIDGRQGGV RESLEEKTMN LAKAVAELIT SNLKNGDGTP    50
    VECVIADGTI GRVAESAACA EKFEREGVGA TITVTSCWCY GAETMDMNPY 100
    YPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGRD VQDLNDNSIP 150
    ADVAEKILRF ARAAQAVATM RGKSYLSMGS VSMGIAGSIV NPDFFQEYLG 200
    MRNESIDLTE IIRRMAEGIY DKEEYAKAMA WTEKYCKKNE GNDFNIPEKT 250
    KTRAQKDEDW EFIVKMTIIM RDLMQGNPKL KELGFKEEAL GHNAIAAGFQ 300
    GQRQWTDFYP NGDFSEALLN TSFDWNGIRE AFVVATENDA CNGVAMLFGH 350
    LLTNRAQIFS DVRTYWSPEA VKRVTGKELT GMAANGIIHL INSGATTLDG 400
    TGQQTNANGE PAMKPCWEIT EGEVEKCLEA TTWYPANRDY FRGGGFSSNF 450
    LSKGGMPVTM MRLNLIKGLG PVLQIAEGWT VEIDPEIHKL LDERTDRTWP 500
    TTWFVPRLCD KPAFKDVYSV MNNWGANHGA ISYGHIGQDV ITLASMLRIP 550
    VCMHNVEEDQ IFRPAAWNAF GMDKEGADYR ACTTYGPIYK 590
    Length:590
    Mass (Da):65,341
    Last modified:October 25, 2004 - v1
    Checksum:i043D6B2AAED8DD0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD47002.1.
    RefSeqiYP_097536.1. NC_006347.1.

    Genome annotation databases

    EnsemblBacteriaiBAD47002; BAD47002; BF0253.
    GeneIDi3082267.
    KEGGibfr:BF0253.
    PATRICi21046296. VBIBacFra17906_0283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD47002.1 .
    RefSeqi YP_097536.1. NC_006347.1.

    3D structure databases

    ProteinModelPortali Q64ZS4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295405.BF0253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD47002 ; BAD47002 ; BF0253 .
    GeneIDi 3082267.
    KEGGi bfr:BF0253.
    PATRICi 21046296. VBIBacFra17906_0283.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000256031.
    KOi K01818.
    OMAi FWEISDE.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
      Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YCH46.

    Entry informationi

    Entry nameiFUCI_BACFR
    AccessioniPrimary (citable) accession number: Q64ZS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3