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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BF0309
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei136 – 156HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei313 – 333HelicalUniRule annotationAdd BLAST21
Transmembranei399 – 419HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001087781 – 422Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST422

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64ZL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLFEWLH KLNFPGAGMF GYTSFRALMA IILALLISSI WGDKFINLLK
60 70 80 90 100
RKQITETQRD AKIDPFGVNK VGVPSMGGVI IIVAILIPCL LLGKLHNIYM
110 120 130 140 150
ILMLITTVWL GSLGFADDYI KIFKKDKEGL HGKFKIIGQV GLGLIVGLTL
160 170 180 190 200
YLSPDVVIRE NIEVQKSENE IEVIHGTHDL KSTQTTIPFF KSNNLDYADL
210 220 230 240 250
VGFMGEHAQT AGWILFVIIT IFVVTAVSNG ANLNDGMDGM AAGNSAIIGL
260 270 280 290 300
TLGILAYVSS HIEFAGYLNI MYIPGSEELV IFICAFIGAL IGFLWYNAYP
310 320 330 340 350
AQVFMGDTGS LTIGGIIAVF AIIIHKELLI PILCGIFLVE NLSVLLQRFY
360 370 380 390 400
YKAGKRKGIK QRLFKRAPIH DHFRTSMSLV EPGCSVKFTK PDQLFHESKI
410 420
TVRFWIVTIV LAAITIITLK IR
Length:422
Mass (Da):46,884
Last modified:October 25, 2004 - v1
Checksum:i3DB049C9BCD6D291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD47058.1.
RefSeqiWP_005796732.1. NC_006347.1.
YP_097592.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD47058; BAD47058; BF0309.
GeneIDi3081737.
KEGGibfr:BF0309.
PATRICifig|295405.11.peg.332.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BACFR
AccessioniPrimary (citable) accession number: Q64ZL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 25, 2004
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families