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Protein

Glutaminase

Gene

glsA

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691SubstrateUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Binding sitei172 – 1721SubstrateUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Binding sitei248 – 2481SubstrateUniRule annotation
Binding sitei266 – 2661Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:BF0455
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GlutaminasePRO_1000048324Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ64Z72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64Z72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKISISQI KEVVQQAYEQ VKGNTGGKNA DYIPYLANID KNLFGISVCL
60 70 80 90 100
LNGQTITVGD FDYRFGIESV SKVHTAILIL RQYGAQKVLE MIGADATGLP
110 120 130 140 150
FNSIIAILLE NDHPSTPLVN AGAISACSMV TPIGNSDKKW DAIVQNITDL
160 170 180 190 200
CGSAPQLIEE LYKSETATNF NNRSIAWLLK NYNRIYDDPN MSLDLYTRQC
210 220 230 240 250
SLGVTAQMLS VAAGTVANGG VNPVTKKQVF DSELTPKITS MIATVGFYEH
260 270 280 290 300
SGDWMYTSGI PAKTGVGGGV MGVLPGVFGV SAFAPPLDGS GNSVKAQLAI
310 320
KYIMNKLGLN VFNGARVTIV D
Length:321
Mass (Da):34,385
Last modified:October 25, 2004 - v1
Checksum:i56F34BB378067E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD47204.1.
RefSeqiWP_011202007.1. NC_006347.1.
YP_097738.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD47204; BAD47204; BF0455.
GeneIDi3081825.
KEGGibfr:BF0455.
PATRICi21046676. VBIBacFra17906_0471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA. Translation: BAD47204.1.
RefSeqiWP_011202007.1. NC_006347.1.
YP_097738.1. NC_006347.1.

3D structure databases

ProteinModelPortaliQ64Z72.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD47204; BAD47204; BF0455.
GeneIDi3081825.
KEGGibfr:BF0455.
PATRICi21046676. VBIBacFra17906_0471.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46.

Entry informationi

Entry nameiGLSA_BACFR
AccessioniPrimary (citable) accession number: Q64Z72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.