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Q64Z17 (PYRE_BACFR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:BF0510
OrganismBacteroides fragilis (strain YCH46) [Complete proteome] [HAMAP]
Taxonomic identifier295405 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110669

Regions

Region123 – 13195-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1271Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64Z17 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 8EA9C26C7381C8CD

FASTA21223,504
        10         20         30         40         50         60 
MKNLERLFAE KLLKIKAIKL QPANPFTWAS GWKSPFYCDN RKTLSYPSLR SFVKFEITRL 

        70         80         90        100        110        120 
VLERFGQVDA IAGVATGAIP QGALVADALN LPFVYVRSTP KDHGLENLIE GELRPGMKVV 

       130        140        150        160        170        180 
VVEDLISTGG SSLKAVEAIR RDGCEVIGMV AAYTYGFPVA EQAFKDAKVP LVTLTNYEAV 

       190        200        210 
LDVALRTGYI EEEDIATLNE WRKDPAHWET GK

« Hide

References

[1]"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YCH46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006841 Genomic DNA. Translation: BAD47259.1.
RefSeqYP_097793.1. NC_006347.1.

3D structure databases

ProteinModelPortalQ64Z17.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3082256.
GenomeReviewsGene locus BF0510 in contig AP006841_GR.
KEGGbfr:BF0510.
PATRIC21046786. VBIBacFra17906_0526.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
PhylomeDBQ64Z17.
ProtClustDBPRK00455.

Enzyme and pathway databases

BioCycBFRA295405:BF0510-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BACFR
AccessionPrimary (citable) accession number: Q64Z17
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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