Reviewed, UniProtKB/Swiss-Prot Q64YD8 (AROA_BACFR)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BF0737

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099666

Sequences

	Sequence		Length	Mass (Da)
	Q64YD8-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 8C5A1D553200449C	FASTA	410	45,574
	10 20 30 40 50 60 MRYLLSAPSQ IKATIQLPAS KSISNRALII HALSKGDDVL SNLSDCDDTQ VMIKALTEGN 70 80 90 100 110 120 EVIDILAAGT AMRFLTAYLS STPGIHTITG TERMQQRPIQ ILVNALRELG AHIEYVRNEG 130 140 150 160 170 180 FPPLRIEGRE LTGSEITLKG NVSSQYISAL LMIGPVLKNG LQLRLTGEIV SRPYINLTLQ 190 200 210 220 230 240 LMKDFGASAS WTSDQSILVD PQPYHCLPFT VESDWSAASY WYQIAALSPQ ANIELTGLFR 250 260 270 280 290 300 HSYQGDSRGA EVFARLGVAT EYTETGIRLK KNGTCVERLD EDFVDIPDLA QTFVVTCALL 310 320 330 340 350 360 NVPFRFTGLQ SLKIKETDRI EALKTEMKKL GYILHDKNDS ILSWDGERVE QQACPVIKTY 370 380 390 400 410 EDHRMAMAFA PAAIHYPTIQ IDEPQVVSKS YPGYWNDLRK AGFGIKVGEE

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD47488.1.
RefSeq	YP_098022.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3081172.
GenomeReviews	Gene locus BF0737 in contig AP006841_GR.
KEGG	bfr:BF0737.
NMPDR	fig|295405.3.peg.772.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q64YD8.
OMA	EDHRMAM.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0737-MON.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BACFR

Accession

Primary (citable) accession number: Q64YD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)