Reviewed, UniProtKB/Swiss-Prot Q64YA5 (SURE_BACFR)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	BF0770

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235592
Sites
	Metal binding	13	1	Divalent metal cation By similarity
	Metal binding	14	1	Divalent metal cation By similarity
	Metal binding	44	1	Divalent metal cation By similarity
	Metal binding	100	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64YA5-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 8866C99689156505	FASTA	255	28,007
	10 20 30 40 50 60 MENKRPLILV SNDDGIMAKG ISELIKFLRP LGEIVVMAPD APRSGSGCAL TVTQPVHYQL 70 80 90 100 110 120 LKKDVGLTVY KCSGTPTDCI KLARNQILDR KPDLVVGGIN HGDNSATNVH YSGTMGIVIE 130 140 150 160 170 180 GCLNGIPSIG FSICDHAPGA DFDAAGPYVR RIAAMVLEKG LPPLTCLNVN FPNTQEIKGV 190 200 210 220 230 240 RICEQAKGHW SGEWQACPRR DDANFYWLTG EFIDHEPENE KNDHWALANG YVAITPTVVD 250 MTAYHFMDEL KSWEL

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD47521.1.
RefSeq	YP_098055.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3082987.
GenomeReviews	Gene locus BF0770 in contig AP006841_GR.
KEGG	bfr:BF0770.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q64YA5.
OMA	SINIPIK.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0770-MON.
BRENDA	3.1.3.5. 868.
Family and domain databases
HAMAP	MF_00060. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
ProDom	PD005378. SurE. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_BACFR

Accession

Primary (citable) accession number: Q64YA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)