Reviewed, UniProtKB/Swiss-Prot Q64Y02 (DXS_BACFR)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BF0873

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 648	648	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256376

Sequences

	Sequence		Length	Mass (Da)
	Q64Y02-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: CB93E96EAEE9F0BD	FASTA	648	71,933
	10 20 30 40 50 60 MKNEPTYSLL NAINYPKDLR QLSVDQLPEV CEELRQDIIK ELSCNPGHFA ASLGVVELTV 70 80 90 100 110 120 ALHYVYNTPY DRIVWDVGHQ AYGHKILTGR REAFSTNRKL GGIRPFPSPE ESEYDTFTCG 130 140 150 160 170 180 HASNSISAAL GMAVAAERKG EKDRHVVAVI GDGSMSGGLA FEGLNNASST ANNLLIILND 190 200 210 220 230 240 NDMAIDRSVG GMKQYLFNLT TSNRYNQLRF KTSRLLFKMG LLNEERRKAL IRLGNSLKSL 250 260 270 280 290 300 AAQQQNIFEG MNIRYFGPID GHDVKNIARI LHDIKDMQGP KILHLHTIKG KGFGPAEKQA 310 320 330 340 350 360 TIWHAPGKFD PVTGKRIVAN TDGMPPLFQD VFGHTLVELA EKNKRIMGVT PAMPSGCSMN 370 380 390 400 410 420 MLMDRMPDRA FDVGIAEGHA VTFSGGMAKD GLLPFCNIYS SFMQRAYDNI IHDVAIQKLN 430 440 450 460 470 480 VVFCLDRAGL VGEDGPTHHG VFDMAYLRPI PNLTISSPMD EHELRRLMYT AQLPDKGPFA 490 500 510 520 530 540 IRYPRGRGSL VDWECPLEEI PVGKGRKLKD GNDLAVITIG PIGKLAARAI ERAEADTGIS 550 560 570 580 590 600 VAHYDLRFLK PLDEELLHEV GKKFRHIVTI EDGIIKGGMG CAILEFMADN GYYPEIRRIG 610 620 630 640 VPDQFIEHGS VQQLYHLCGM DEEGIYKVIT KNKLRMDAPV ESCMATHS

References

[1]

"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006841 Genomic DNA. Translation: BAD47624.1.
RefSeq	YP_098158.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3081652.
GenomeReviews	Gene locus BF0873 in contig AP006841_GR.
KEGG	bfr:BF0873.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q64Y02.
OMA	MQELPHP.
Enzyme and pathway databases
BioCyc	BFRA295405:BF0873-MON.
BRENDA	2.2.1.7. 868.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BACFR

Accession

Primary (citable) accession number: Q64Y02

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)