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Q64UQ7

- GCSP_BACFR

UniProt

Q64UQ7 - GCSP_BACFR

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BF2025
    OrganismiBacteroides fragilis (strain YCH46)
    Taxonomic identifieri295405 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002197: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_0000227091Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi295405.BF2025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64UQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiHRYRTET.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q64UQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTDLLACRH IGVNKADAEV MLRKIGVASL DELIDKTIPA NIRLKAPLAL    50
    PAPMTEYEFA RHIAELAGKN KLFTTYIGMG WYNTITPAVI QRNVFENPVW 100
    YTSYTPYQTE VSQGRLEALM NFQTAVCDLT AMPLANCSLL DEATAAAEAV 150
    TMMYGLRSRN QQKAGANVVF IDENIFPQTL AVITTRAIPQ DIEIRTGKFR 200
    DLEFTDDLFA CVLQYPNANG NAEDYREFTE KAHTANCKVA VAADILSLAL 250
    LTPPGEWGAD IVFGTTQRLG TPMFYGGPSA GYFATRDEYK RNMPGRIIGW 300
    SKDKYGKLCY RMALQTREQH IKREKATSNI CTAQALLATM AGFYTVYHGQ 350
    EGIRNIASRI HSITVFLEKS ISKLGFKQVN KQYFDTLRFI LPDSVSAQQI 400
    RTIALSKEVN LRYFDNGDVG LSIDETTDVA AANILLSIFA IAAGKDFQKV 450
    DDIPEATIIS EELKRQTPYL THEVFSKYHT ETEMMRYIKR LDRKDISLAQ 500
    SMISLGSCTM KLNAAAEMLP LSCAEFMCMH PLVPEDQAAG YRELIHNLSE 550
    ELKVITGFAG VSLQPNSGAA GEYAGLRTIR AYLESIGQGH RNKVLIPASA 600
    HGTNPASAIQ AGFTTVTCAC DEHGNVDMDD LRAKAEENKD DLAALMITYP 650
    STHGIFETEI VEICQIIHAC GAQVYMDGAN MNAQVGLTNP GFIGADVCHL 700
    NLHKTFASPH GGGGPGVGPI CVAEHLVPFL PGHGLFGNSQ NEVSAAPFGS 750
    AGILPITYGY IRMMGAEGLT MATKTAILNA NYLAACLKDT YGIVYRGANG 800
    FVGHEMILEC RKVYEETGIS ENDIAKRLMD YGYHAPTLSF PVHGTLMIEP 850
    TESESLSELD NFVLTMLTIW NEIQEVKNGE ADKEDNVLIN APHPEYEVVS 900
    DQWEHCYTRE KAAYPIESVR ENKFWVNVAR VDNTLGDRKL LPTCYGCFD 949
    Length:949
    Mass (Da):104,679
    Last modified:October 25, 2004 - v1
    Checksum:i8826948720335871
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD48772.1.
    RefSeqiYP_099306.1. NC_006347.1.

    Genome annotation databases

    EnsemblBacteriaiBAD48772; BAD48772; BF2025.
    GeneIDi3084252.
    KEGGibfr:BF2025.
    PATRICi21049715. VBIBacFra17906_1971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006841 Genomic DNA. Translation: BAD48772.1 .
    RefSeqi YP_099306.1. NC_006347.1.

    3D structure databases

    ProteinModelPortali Q64UQ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295405.BF2025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD48772 ; BAD48772 ; BF2025 .
    GeneIDi 3084252.
    KEGGi bfr:BF2025.
    PATRICi 21049715. VBIBacFra17906_1971.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi HRYRTET.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
      Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YCH46.

    Entry informationi

    Entry nameiGCSP_BACFR
    AccessioniPrimary (citable) accession number: Q64UQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3